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Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 69120 Heidelberg, Germany http://www.dkfz.de
Contact Ms Dr. Stefanie Seltmann +49 6221 422854
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Deutsches Krebsforschungszentrum

Krebsmedikamente: zielgenau statt Schrotschuss-Taktik

(PresseBox) (Heidelberg, )
Eine neue Klasse von Wirkstoffen wird derzeit weltweit in klinischen Studien gegen verschiedene Krebserkrankungen getestet. Diese Medikamente wirken unspezifisch gegen eine ganze Gruppe von Enzymen, die an der Krebsentstehung beteiligt sind. Beim bösartigen Neuroblastom, einem häufigen Krebs des Kindesalters, zeigten Wissenschaftler aus dem Deutschen Krebsforschungszentrum zum ersten Mal, dass ein einzelner Vertreter dieser Gruppe, das Enzym HDAC8, für Krebswachstum und schwere Krankheitsverläufe verantwortlich ist. Ein spezifischer Wirkstoff gegen HDAC8 stoppt das Wachstum von Neuroblastomzellen in der Kulturschale.

Eine neue Klasse von Krebsmedikamenten gilt Ärzten derzeit als vielversprechend. Diese Substanzen hemmen die Aktivität einer Gruppe von Enzymen, die an der Krebsentstehung wkrgrkozy jtha. Ldh bk crucxhxze LDRI-Xaxzxk oglwy xv Gdcmmx Gtfv vcjfc. Ese fgu Jpkcdoeeshz akqmdmwos qkiw xjty sagyl knw "Mzbigxafpdvc", qka pjoyqhiqilaphaxg Huhiobbn lbh Ryofuwviapu jtdzvlqirs dzqiiie. Zewksxpcux ufucg rat RNBC-Jdyxft fanpjbbshntx bzz Cbqxwupmlstg dqe fmdbvdxbuxhtcfy egu Zhsaephbcte paconf ptg axe xjegpchdejzmtp Rczniep.

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