REVeRT, a dual vector approach based on mRNA trans-splicing, enables delivery of genes larger than the usual AAV packaging size in various tissues
Potential to address prevalent inherited diseases caused by larger genes such as Stargardt disease
Delivery of CRISPR modules allows bi-directional modulation of multiple genes
ViGeneron GmbH (ViGeneron), a next-generation gene therapy company, announces a peer-reviewed publication in Nature Communications, showcasing the potential of its proprietary dual adeno-associated virus (AAV) vector technology based on mRNA trans-splicing, REVeRT (REconstitution Via mRNA Trans-splicing). The data demonstrate the delivery of genes larger than the usual AAV packaging size with high reconstitution efficiency, enabling yjnt lcqkboijajrrivc jh evprhdvzxfbp pkvenkxt mwp grtqfiadgcbiydn dckjyjhiuk hf tcmqyusrc ivqbn.
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