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Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Hofgartenstraße 8 80539 München, Germany http://www.mpg.de
Contact Mr Dr. Roland Ullrich +49 221 4726226
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Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

Fastenzeit für Tumorzellen

Wissenschaftler schneiden Krebszellen die Nahrungszufuhr ab

(PresseBox) (München, )
Tumore müssen mit ausreichend Nährstoffen versorgt werden, um wachsen zu können. Um die Nährstoffversorgung sicherzustellen, regen sie benachbarte Blutgefäße mithilfe von Botenstoffen zur Sprossung an. Wissenschaftler vom Max-Planck-Institut für neurologische Forschung in Köln haben nun eine neue positive Rückkopplungsschleife des Hormons VEGF identifiziert, über die VEGF durch Bindung an den VEGF-Rezeptor-2 auf den Krebszellen seine eigene Ausschüttung ankurbelt und so das Tumorwachstum beschleunigt. In Versuchen an Mäusen mit Lungenkrebs schalteten sie die zuständigen Hormone aus und verlangsamten so das Wachstum der Tumore. In Kombination mit anderen Hemmstoffen schrumpften sie sogar. Damit haben die Forscher die Existenz des VEGF-Rezeptors-2 auf Tumorzellen
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