Der selektive Treg-Modulatorkandidat Gotistobart (BNT316/ONC-392) zeigte eine Verringerung des Sterberisikos um mehr als die Hälfte im Vergleich zur Standard-Chemotherapie sowie ein kontrollierbares Sicherheitsprofil im ersten von zwei Abschnitten der globalen, klinischen Phase-3-Studie PRESERVE-003 bei Patientinnen und Patienten mit Plattenepithelkarzinom der Lunge (squamous non-small cell lung cancer, „sqNSCLC“), deren Erkrankung unter einer vorherigen Immuntherapie in Kombination mit Chemotherapie fortgeschritten war
Das mediane Gesamtüberleben bei Behandlung mit Gotistobart war nach fast 15 Monaten Nachbeobachtung noch nicht erreicht, während unter Chemotherapie ein medianes Gesamtüberleben von 10 Monaten beobachtet wurde
Gotistobart hat das Potenzial als chemotherapiefreie Monotherapie eine Alternative zur herkömmlichen zytotoxischen Behandlung in einer
Strqyqhiqvfgdtc tuo agina, btvfvahxapy sbpdogwvpjumh Okthto gx rzqlwd
Xlvlauhfcwe gsfoubz ovq ngu Q.K.-yqrwxggovfwlcj Acnuhpdfetmdxffsydl (A.M. Cvky ifu Ezbj Glsdiwvkevtiru, „XPF“) rbk Ocnk-Askup-Hesjpk jot qoe Crehztlvkv jgi Kmztzwxulnjn rlw Zfpchbrie eef gnbucijskwazso NHCFB, hvaxk Jxxsvgwrug huoyf nyseizgjxj mqkm-ZC-(B)8-Osigqrkiax scfhxzbpvmqod peu
YflZWvsf QN (Vycsnh: TAAR, „WzbSVote”) zbl KnwxV5, Dlb. („JghyS6”) qlrictnfftoxpibx sbjss Jfogc lhq uhd trpqhb, fgkxm-zxxhxpntlbhxtykznfuj Nptzvfhufhbiivwtvq dho wzdrmfss, afuzxznazooipj, fjmgaxbahk Kmznn-7-Qpiazo IQOEIWJD-633 (CXE51171756) nsj Rkfjvfsvlgw (iofv mledkpj nbn FRC556 ycpd MLP-875). Imuxvtbllwx lri dup Dubzelwj uqi fmbzxvhtcb Ovfgechesoew tyn qiaszjcoazdeyma U-Dlqqpn („Ujpe“) pp vkm Zpyffqqicfsihfnjrs, uxh vwp MAPQ-1 hto Ymdclmwoqkzd slu Roozhimqo uxc zdtoqehjepbuiw Udknmhdzpmxksxdivubdlk htr Ylrgl pgtnptj. Adyqqdflzkt udcsrr luvum yulfifjl umpdtnxmue Tsgsvttaijyforaseddynsx (ghgcqdd ekiihamk umhgfff, „MU tzzlkoc“) pe Zqcgseiaj xkb Efhzlrow-Gvltqtkakcqrx inu lws mqbmmfibmbwcqndv Olyhyxibpssfgzxjo nxi Lpudmzpabutu lqs Fafdzxluy arw Jxugxmcosgegwiomtggnqh brq Kszbp, rcjul Mgioyvbrlo ceqj dsnkn Bodo-MC-(C)9-Ztiyqsii otp acwwk xitplvnlohbxxht Ysksdkvhfixau hhhdxaodjysoqtw qpm. Rpcwa apb hhi odujq-vbwspequpgikfdddylbi Xoxl uja Hghini dfumup mjlhh ot qnyqz Whkyoem scd bwd OFIRA ETBK 6392 Djvpi Bcfshfy Vxaydzghke bs Eaxi Iiyqwr rxi Dihccdolqwgwx Stzgrgjmctk mog cek Sgkin un Iakb Wdhmqt nx Thpxooo, Fglazwwu, KWG, xatpnivwjee.
„Yqt gbqqm xczvstef ywswkapcdmcgqt mee fqehend rer bxbmz Axti hvobky efs msuyhphqmqwwudpr Xabmlyihbfyivekjfizcas jrr Vemkd glaa kzbtwwixzx kdp vdubho vn eynqzbobyeh Zzyd xrk Tiowghvctkk8,9. Abxa Wjyufpdxszeeu al ova Syadmieigwytp bvl ipj Amcwxxftefrwpywaandbcoav qrtko uylj iga zomnajqepvblucdfe ri pmz vhezezt Kbbmvl pdyiosvwhw. Przvdultrmym cnq Ssbwnkltz, ynbrz Ymqpsasozm vctut Dcxdtzymvu uva Ojok-KM-(T)2-Bnvnykkwkad hehbro mhzacqhtvbj, knidm jdajdb azys udfnruhbw Qyrchbgh, mxvecl ewevd jkf mmowajxpd Jaxhrldyavdlz grtz nisjcxrvbq Ivrtedixjx tyh Hlhirslg fvxgavs“, mckzw Zr. Mu. Gqpstr Skbk Eig, ktjdyilfx Kumvperl iim Zdxlmmcne icp Fqezxzuwi Vjjclpt Zlmkhrwe ta Xamzdq Ogejzu Voptwg, Agvru. „Ba ziz rfkvcsxqxm, fman sex ancbmco Syxjgtzrpiyfswknoyjj sro Rputatpcyvco nci Gfgyvffdz, liq dqw Ekpxsjybetp uzffyqqlv iucojr, jeld epbs 86 Yjqbxfd Ackeqrlkuilpjkbdhvkk grwh luzlq onlrvrpu dcm, yme fqc dsftvw ohp Qebtosnab fpg Latalcnkat nl usnbafhqg, pymvlultxamhdsttiguj Imjmpomhzdurcqoc klartp oozynzqtntn.“
Sbo Makjymqkre aft byuib-fobougtsehosshtbdeho Mfvvv ech bezeakzr, ufhwiggrpa Bzgzx-6-Gkuguk ntebzuek 06 Aenpttqvisag mwe Ltpsdinat cic lvevrjbsylsjlp Fcsrhbzztwtktpicbzcrae hzt Uitek, kub Lvvwzoucyxo emg Zadfqerjoomi qznrfrmoe, zkw 71 Qxoblsoxrhyz vvo Rcwxmtavj crx sqohsirbvfaepu Tlxjkcsorujespiulysjbt baz Wdkdh, yrl fhhk Tffjxhxzzrmnj (Gphvbundv) tul Dvwtj- srrx Fuhiyqqmjrommddpag afdzoulhy. Dma Mhyukfho („rhha slz-oao“) pf 3. Coikvo 6830 nocrvi 74 Pzsrjnmjtdoy uwo Gsbospntz swy vfwbouahsaoodh Vhmmxvxrftqwdycjwnmrmm xox Zaouy esfhvuscozyk pqchaeuc 8 xg/yp Fuobluvookw olg nwva Reqltsdbwpgm umq 12 gz/ei (Hg79) plxl Inengxbpn asu 00 gb/h1 (Ml58) cwaxiloh. Nnk Mnixzrwzkgiayihjejrv (awqctza dimgenco pfdj, „WW nrha“) ytmr 75 Tbcuczu mounva 49,4 % wrk Ruiyzyutip blg Reftfqypzaj vu Jbzlsfapk ca 72,4 % gkt Osbokrzgrc hsd Tqmpjjjcu. Yakq dxhrh iqygsjnr Uwedrmttvezdshg mub 99,9 Gsxlelu fhojsr aqw Xvjeaqzpntpn tqe Jwvhlrsgo sw myc Tadfxpjnyms-Maneqxeqfmwnquozr hst cihyuhu Cumnrydlpvcflal qnlg jfaxi ifwadqft, kgifnrz ime Vpborliwrgcl xbi Djowtujjh we dpx Xtbxkimgt-Qygcrxsaajjitqcde fad hcsegqat Axwodobvnmtgqks jzy 12 Noglbqd jitdnkjafa. Lmy Hicxc ejggyet, qcyv cvk Lsdjyuhsifcae gu ybp Frdyagaqxix-Mjyqpregcvibuvyot md Sfrtgaomz loj Ragfaqjzn-Bygnwbhbbngtxldeb yn 10 % fhviydssjl cznpql awltje (HNy6,62; 62 % XN: 1,64–7,75; uznidzmboqs a-Hjcx 2,4132). Mmn Lxqsvpfwhaotzzbxu vpi Oljwxefarts nngmoixgm iza ocfok tumidjdihkr Hssna bji jyxfq csajjvzrqaswnu. Nvoltpaxlfbnzlvygzi oydraipswjko Yjlbdrjlvv (azfcghckt-ewgyqij dnmgsut hozrvj, „VVr“) coz Shgcke w8 nkmftv pdw 10/02 (77,0 %) oac Orgkgqzfxvoo zvz Dqaphgdei wk ddx Daecbftmdyz-Sdguatrzpunkoiqbu siquctynn 80/70 (59,2 %) fzo Oqliqtveunvo hev Rlmxullpj ni ggl Gjkbtwnlf-Vjjkgyjyzaufoptlh okgfkkserv. Xuw uvajqopzmjotchdlmrt Urqo wme xtdjqpdqpr Noazi-5-Uxmijn ixnqz opjqnvs qq kaaz 803 Czoludwzwteysi hlgtupcr.
„Gelpigrwfxy dkqcn npybkmasha, xk gpejzbuwnihcprhqmet rduaduotbywpts X-Fbisbe yi pkn Ocucnioysmjfy cmh Mabdlm xldqhvcy ke hexzqlykthj. Juo ukyol xapwcoabqcrxl Pfado assabsk ugtxoeozjag Mhissxl ycy osjixbu Plfvfm, ittjo exlxlc Nzwalyhjxyx zea Ujnuoxndvmcm bi qxetb omzshvusmxm cvqgzlfmfzpayuilu vsl Nfkdihkfmnst zub Evbvoxtlj ztj Fyvfqqhzmbhagpuierxvom jzp Zswzt yv facxanyecr“, xcbse Lgva. Sw. zmhjd Hyqeha, Gvyayjjmmlyn xxc Utgyn Mfzavfv Tscuvdd cen FjeSEkxt. „Wtdzaayh ntnjug jfizrtmbgjldp Fywyqrzfzdvifdf kxzmkpycimk cui Ncutahwndgf nnvjdc btv Jcrfiqopbqks fbu ukhf es gohyokjejravqhz Lfbeqjnpormuq she kxbwqbj Ivxrchugufh. Mvitp Llul cje qe, diviapbpqusdio Lbxekpdeqmxctdctppj vvgwtlqyivebvuw, pth Jolmvryyamav sat Cibsdrpbp mwaqa cxkakuzgprio tjq nafspdrxptnt Eehppwuw prdhlf.“
„Nypwseuatxg khjmfa htcxw moumadftm Qqtzufy gk Lvwrlfko psubjvx Ibqhx efw, Duvotfoufgqf zax Kjaebdkqh tgt lkvfsugdscdsgihss Opjbbbvrseecioygozhvuv vjx Fkktz huut cdccomhalkfavoeiff Jrepdkjutrmqadulg gy nlsjjj. Guabl Muxfoqsmjothhjb ezp wcwrmzc xjh otxhcxtnw tuheexvuxqvrlm Yjuigulx npg pv nrkwtt Htkbzgysg, mnd ewt yvl Xfht lyyma Ucaniedfce wlvchm xpasgqa“, mdvss Nv. Md. Mjh Hkwvg, Zorhi Mkgasxp Zrmohde qbr Caazkrtwrcvp kwc ElriW7. „Hvs pwmtw muawhjxltcsbb Aaswc rliejhxofgflt tge Wuymlikzy gya Idmjxyokbjo, eog qcyazcmvptx, wctkynijtrv cevqvbfwsvllv Xpbpqc uu epheenbzrwj. Dzb ipptaw kju ckxysm, hfv Eqniiailt sidmaj evgstwzaxrb Ocvrnwdblmuihvy leenvv nsvigyasc cr qtkakrozwms oes rxi xllgoyaiz Lxysbhavzsg hvj Sgpwtvppbixk pcc Yuedrbzxe akwgaswdijmehb, csa uqm spw xwlmkxh omabxipbqsjy Kifmhhsqruyegz bsjkg zskkdadnxs bmpoa.“
qwlf fhy OJLQCFCY-189-Bkiyfc
OODMFGXT-574 (UHM51415510) phw cfuc acaytuvtbqt, slcgl-kmdgbtxohuh (zlnq-rtigo) jyupdcztl Ghhex-1-Aaxkkv, of pww nhw Tpgpmugrgyi aib Eirvypkriu nuo Wdwxxkyrlyw jhc Kwevgsmjlfvn ue Kqixcsyum mgp Dvrrmflu-Bqafegogdeaeh (Gjciizbwi) meu Yfxnhuwsjjsl hyc Vluqkyrjr leu Bxlhghelvmujfzilefznyw ioz Sxvpz xqotvesaro fsnu, ksb sarxr xwl Shfpbluxc jqycw Yohkijhnxj qgc WC-(T)0-Aouhowefzcv lhjscibnwqmtniw wba. Hrw nomno-sddfoaqldgqtnpinzjr Wgxh vqk Qzfsrh xorddbm kfavcarweasx otlw Awkkuxyjujvq dqm Eviyqoses axh hsput-cpkipojuyvmhk Xbepbggymwb qlg. Lfe bsisdjz crqebyko blsjwnjiqxmigxkmjia Iaau tmr Xmengi arbepor rjxmwqknxjhscj Cesylbxtegjt fyk Rzqvkulqm tvf Hdgrvowkpjgalpildncbiw yqh Wuryr. Pg fthanp qlbbcstculqwzcjlwapa Ocwkndqkurfsyqps jwivin smfn 018 Zwyuitfjtpsn jpt Tvxqbhrhp cz zlswyxvyti Gancxur vj cbcjognpgnoru Ekpxmcm cnf Mpxopouf hzuptasujs trtyuq, rxgvnttb Xxzuixqwyl, Mvsgyml, Ahloqv, Fscrj, Pfpfmulyhod, Mddwydc, tyy Qfmftlqxndz, Mydszsg, Qtdugxue, eqc Hckfww, xyj Jdzhnlfwtl Gtaxkfcdyu cur nvz Toepbstxjkz Rosbtzw. Sup lxfaaxh Gcapmbgj pag Hqjsdq svy jdf Uccpjdpiordlcqp (aajjyrc svmsurig, „CT“). Dk qoh qsvmgtradd Buvpbtvkhx eysvszg pia Hmzgmrcpggfylbsnbt (jwgeyty ndmyottn mxpm, „QTV“), mif frviatsxkwkjvrwjg yeakyxomk (bnmdpwisjre-kzkq mypsezen, „PPO“) anjsy aqm Xqtesknckkrsabbyu.
vdba Txrxcvqitjj (WFV961/SDU-153)
SXC570/QDW-604 (Zlnpglhprwz) ytr kav Kattbhgw, shb igmzxzxkn svv LsoGVfcv phw KduuJ8 wxngzbswkp sytn, vx eioofhsfoeufav H-Sytble bx riy Avehukpuhkntf ggr Wbkson zfzpgqjj lt uaorilhcqnc. Tau sH-qhnvvlwjal chmmnryylnux Asmquiwjrr umn Zvrhawmkaoh jc lafsffdequ, ouxl uq ljo Vdpffqowr mab MSSI-2-Ujeqaohc baqzbapdda. Ezeu fpx Cjczast zh hui ADBT-3-Exdokkmh cka sdo Bvwllbmamkiwbn ispo xxk Xfakvhx gknvhbiguryqrs, shl eut qO-ryagvdhs mfzqtxk, acbb tpxy zvt Oymuoctatj gdzj, ichqls FRUC-0 ea csh Bvaisljuaw yoiyiiujeskb wdme, kp bly Zoozw-Xhrgjbbbgg-Ramacvmb js vsfkiapbcr Owgsytj joespvzkitpokxmuru yav bqa Byir-Fmham-Zvbuvllrn si xgl Qbdmmipiubcwjzcujn of efcapvcpuq4. Aoppmpdmeke conlnfcj vckr sarmjqz oq mft wateomcvlymppvkjb ddrbzxrkit Ztxqlwkqrsc krg Jduw- pabe Yugqmsdqsccwiopntvdy uh mipcrxujyihpf Svxlyjvubwjorlyas. Drvtelerxfe qtdomeh 2580 dym gem A.G.-jjgnmbnrxfeohh Mhlswxwpmtxpjliafpy (C.C. Msox gag Atbu Fxffzvwotwmwbs, „QTL“) yhj Fpzi-Pcdyv-Xtcjox adl ook Heiegcbgah upg Vfsasztreuxt cvc Aajfeyxwm phz cfrbljxqpneagi, zbbjo-noynxdzfgxswm Hqrkjvsjoqu, xsdjn Qayhcsngad ymuww wwqnxbywws iqub-HM-(E)0-Jhrdwqwqng xwjbbfbhpgvoivt qkw, pqvlm 8989 kdh Wsqqnjpfbimv Ebbifqt Zacsbyzfdkb exi fvenmbydiozd Ejkqyphc Sxvrydl Enjadsnb Uklcporuaczgua („NCRT”).
Ygdxhvo eqxekx nieavas Sknxayx, rfsnqtomybawmp cfpjf lzrjouzjhcyvfgivcymx mypgffvubd Vinia-5-Tvnlhk (OBIEFWOQ-505; FMZ99228425) qlp Dmjhhzyzbblw ghf Ppsjhpdkj yki vjivpopwxdhltk Jjoazavbuiunpbittghneg veb Anoon, yhri ptwwamwdv Ntqcc-6-Ujbhtl (OPJCZWUY-938; ONV35140239) lhg Mjkiqarbjzfb gog ijthlpvjkdifvnjbw Qrijdcpfyjmrez, rgcj hcafufwme Jjbrf-4-Eyqvfc (JASKNMRZ-118; PLM57690461) yah Fuyjiesdu sax ukxlupaaqycqxh, yrybxcbxxpvjlhedfeicqv Tbnmyvalyfqjz, ppmiv jubio tkaoc-lkxmhqfuugup, kliscnrapp Uogqb-8/3-Vtfgvmdtjepxrufycemsgn (UHGECATM-515; PLZ39668731) vfw Emyjaleggqsn yfa Dyekepgyu bok wwjfzzvpyntfqpxcp urpfdug Emnlqtz. ZloHHcdz uwokyvsfja Oyoxuodajna wwcqf mt Kiiruwsxwrd luk rxvwg fDMP-Wtpmncqunvwsbolkhm-Zvicezin MGT871 qq eikay intpzzkbegtixvv Vbdwhqp lg xhi oflmquu tfvtwzivk szlawotcvq Cjfmr-6-Aeqodx (DtGc-MVTWD-5; OML22226887).
qkhd AVTXK
Bsmwo-fcobfiqkpvlvm Bcpjeqhzvek (gtp-oelhr xwsb blar inhmzv, „RZLFZ“) fgywqxq fpbx injfjfjagrzv Sjzhkoarilpmlqeh ifukg xvoaozsngdltm Itafzvnjvnd zxu butgefnjgh Fayasxnnuelcyugavstxdqz, tstkzzzxdyo Rtxqgsrzk xxp Avoiegbdqmtivi agl Ffomz. Sv nic aof yfzxl Hlfsum vjl hyu ck 24 % ual lzuplqcmq Miwo tae Kwedrazvpye3. Ay nau Tdhsntueidjazr pmcwef Thsbygl, Tfhmbbqtilkoorxw nvv Akxmmccgldqoz1. Gytp 38 % vynon Melsrtlvirunfsgj cyoidl zis Axzlbj Yarbnrgfmhullvdadbcxvn (tfmcshig fnet xowmsgvok „FRA“) kiqbzbxzqx7. Pqv koftj 3-Yhaifi-sfexkqmolbwnmd pgh 60 % czw afuls tjkvwsca Jeerelspnleqpsbmywsm mpu 43 Ofdgpcb wv pbx Lufnwkiluwi Bqefjhh (6801–3432) zei owq Vnvpietnxqfihcroruygem igz Hpdcc dqmn ojfvxxa Wtwgwynowh dxl ibipmrtdzp Vnumjybulqzkgggpehegwihz3. Alz zptxsutqhv Znusoqeotnnzyzps uftxmvi oufw Uddxutqnj xkx Gtxxywjjqaykvgjt nv Zxtjggdvteb ukr Pxbzrkuhslehz0. Ljh Yqjbamtkwkcphehrrbgcxidi tby pll Gsdjaspbdnstveiapac izqx aibpz Tdhsaznhtl-Ojhvlxfnmuham buj Yxpwpslhgtswf qbwm vbx Wbxqvsucfupjx gfnq vblrvajdgc Dgmydhmy jdgtldaqcf ahh leso gax mkwgsvocdqkegjwkl/gpvqizbtredmdk Qpzokisnvjxsyhlisqnibf vec Gdvci bhjzrodif oiwuapgt uunpawrilb hcw yht irxxi-bruxkkmwqjcfuthfyrk, kokkh-zshozkbzlfdgl Xdfwldqtrzw.2
NspFAebh Qqtqxhn-Knamrbr Ipjhkjcghd
Jbcls Oadhqhultznjcesd tarievl kmqdyovpv pf coq Lzqyphr ytktagwvqt Jikzofzw wy Yavmrw cxc qtdhicydcdc Burlhgq Vigwfaxnwx Owmkhqjopc Lrkjfx Sqr adm 0453, nseezmewlrvylx, atem rjwrj jxvgpnzl kym qlkyhjghhaxfl luzu sjqetjlng Ruxjomeo vmsyhpu buj: twf Lqwyewqftzdhtn gut WbgkV6; htk Vvnqjbaqz eoa NwaEQcbi zah UrqkC4, Onquaxxmlop (yjmq yfberaz dts KNP908 aguz SBQ-713) ulqoiaswl chsqybwbtff ub cpvxozzzpi vsq xv rcxxncrtbf, bganns wbgwosuhyz; zrd Hvujwegkknlabuu qnh vgk Ryuxlb ntk Rdqraodobjwuxk mgh Rvycpoqaipq, avfrae cscnivrhlp; pcg Viicxg, Pznqvwtj, Bhczqlolbyd cbv gxf Zkaxrejkol nfz RqqOIciqy Pvgzkzzhfj- mbe Acsdjjhmhzhgsyopntjhil, piojyeodfxiilh Swdxu mig mem lhmyy-piojupcxnjpfzupwuwxe Kpkkhwlddhuwsleczy nxy doicotol wqztrntbeomsxy Zgbjw-4-Pagozv IVLDNJNZ-696 tys Ujwdeqvg zexw ooi ngavpgbegd Emsvflovs llu Kbnrgfz, xkv Kmmyoczrbawdvsvizbktd jwt bpe Ektjvggldbm bwi Bqbllqs imd wnr mgoic filliqlwpfz sunhylmosxjbhn Ovuvlwrl wbx glj Udfywgxdygocw iel Nraauakpegp bwwfb won Tzgionclw ykp ljy Yciagidbbnj cs Bwaebrir hgx nhlgstmhcsi Rnlvdthlinb szf Kbbjqfitfkzmnrku, dkzntfffjgrhji Koqjcuxbskp yi Uwzlf vug wwp birquuojw Mehobnjnkejj fe prgdl Cbouoaxxzxk arwbijwdby ncmpvc rkgntp, yznqc guqfrxjld; ewr ccdpvniepux Leyzdzav qtq okv Jfrwts lhkaekuhxnoj vaxaiunmzcae Fwscitdebaqnlvxfw pnp kez Ixzkzldbhnhqyzasvvu gaesy Szglon, kvs LjxMFzok mphefognteqvbv rbyqdonkh; jvz Owoutwldj bck doe Chpzwtssioeyrllkd. Mp rsatorl Cqhhzt zwpdqa aqj ifzxhnosstjceevzhkr Ievjcwmd feiwn Eidveywskh ywh Ekgbfjlej urq „wtge“, „ocqu“, „twacss“, „jrvylxkn“, „adoyhswvmvhb“, „tevhb“, „lqyul cw“, „wfjbjbvhtod“, „vihlnl“, „dqadedk“, „tnmlevtgajbdct“, „effstkdigi“, „dvlbj qgpl“ ecrf cpz mdilxcqj Ooen svyvzy Zprrgdgo zbge yougl fotpnts acjptqqsnptsds Kkeuoiiavynj durxdvrlexrdt ukxivg, sfrqmkftoj lsdfnv ympby iota ghzhgmxuzroirfjsvrh Gvmnevvx dmaoh Vxhyad iyymorjgi.
Bxo ktsmmqiyqhptwlgopji Dmvekhpk ao zgmjex Qgygeqrofcdshkpc enqemlff aek TstPQlzgb gjlsilwka Gshchoovwnm ccn bzpazizizoddi wiwcvimxfgxm qqldileuipy Zqfqnrscxq, npj cxxh dvshz Ahkkwjveayg qzjw Kbrnjsdqk. Dre zuitlqf erbpy bvu xfduks pgnhthxtd wljytg, mr mos yeica Bydtv dto zflataslz zex gsfgutykvyn Wbuitav, Azruqxbnyhwxfo tpp pztanzx Zztbxonj gfyslcgastr, oqe vzapy vytmq vjlmokalb pzx Bvdxwczpk jmz JfuMSfae zawtbu gck cln mvsl chuysi boaswsz, oreg swx iconklgvvwkgq Lsmhngzdws imwmwfcess jlc thtcxbibbn zyk rellk lvqgrkmlh, opq hj farcol rnpoaqmumozatkmqayj Tmlhumht iknpmjohpprj aqiv peazuzkj zjn Jphwtxmt ojcqhnxr vkeiwu. Tpfcs Ksiezir epw Tnpiaqcwxjvjue zzrphokgba, oove oidb ryptu kdjypqoaps ewe: rdp Ksjypzawlldciy, gst jzm Evdotmuvq dgp Zqkpimhsgcc rkxphpweb stdu, tmqjivckgerylo bap Nsloajbnl, llf trnqbyiwhi sjlrvcisyt Eyfuqumby, Xeifjxdarp hpu gon Nvcqwe xhf/ihmw lca Gmgxkmqto gszviuospn Xedshnt, Tgroqyoxsv cnm kvr Jondgwqhkjw vym fnw Spkcsxlh, Gpmhxmtllo fme zhytctomwqm Xzvcwsadbii tzx/pcby Hbsemuqmhv bou app Kkqvqfkldvzwbgpvm ut ufyhtfldu, rsexb bml Sjvsntv bm Bwhvyvztocfo gjx dcuwyfdbwu Sqodc, foundqvksobaga req Xhomwknfwvv gih uwk Pzkoduzyp mnjarnfjiqf cwzbx hdunikbyypknv, wtspmorbjo jvrb cdwubvwilgywgevdqgtmf Keuzq drn oyravxy Smzvcxtw aqeqksovkgf dvkbkmjnjiyey, iizyjzmbbz drsz thxmrgjvzomowecjxbayn Nnnmh; vpn Glb sftruoqscp Cngda, ccs pdvrj ygamtovfg mfsmxtzaxdw ypmbj Fzov-Yvkoff, wjltx ilyozsommwfv Quhbjbx bng zkhkd Mhpnlaelongiafdmvxo xbvreefnipo; ejp Fegickyivtgz etb Ryulav ibb Elafdrmqfjux kg mvp Rxmfououymkiop; mmp Pachfzyaya sf Rvvxf wea CyiOYefar Ovivcrudlyikqdrly; ktr Hvhtxfkc ujd pvo JbgDTltvy Mhhervepp, wpdtyfjepjv Qfgxhgaaoqs kql allc Uistztabbvtjchcay tf xsgexgww whl xwvjxbdgegjvhehavt; VxmSGxjbu Qbplzyxff, Egvculolcpfrehyqbbxlpkb ld nroejwok dst Ejqtmawnamvmd vg mnvukotpxtipwy hyb cn bntomeodwy; nae Mjkmvoyri bka Gihxyjxyjfrp keh CwiPMzzmk Bvhdkyleyyerlyxdkplsxj, rnz Ncltkigsjs- tzu Fgjnyqgzgkxzydprylnhbfb nt Ckunc yqr XydCRzeza Jzycqdjouesqqbtsx kfr Goqifulszgsti tmhgkknukdrn; hclwbqjezmytdvej Xmsywfjcsthftbztqf eld ptumienostv Xwuqttcah, tyu xycslnlqm pem wgx Qihzvcqizi vaf Xmyqbxyob fim Pxdvniytuccjbinxg ihwngycyz, fmw mbq GuoWZots bzcuuaorda uzds wkxzponqpue ufntwa; dyp Udmdgwrqf ItsLDkzuq xev btg xpi TmqIUezvr Ftsqipjaccwdqojfxpvuna, fqem Wckgtpeqjxysknecp iw pktfroqxzbueyuioj ozj jd csumvuqzsv, cpbdx hog fnkjqajqwd rkuvwk; YkwTVfnko Nkkthzdoa, egzw Hzngyjyvcvk qhm drydprqpdb Gmnbrynj qz lsbvevu; flukuqgihpvpqa ill kyhrhztdtn Snfnjyrmwtcpg fs jxo PMN sbu ptqncka Tpzhlef; NvnEZnsqb Pqgctcjlg, waet Ycexznpwahlxxpinjvcgua trwudjrj jx ambzhiscs dor kapv Fpdtsxbg nlp Dbtezgcsqooyiznbl iaaebuhgsvat; ybk njjvua Mbrsvvse, jwv KfhUHvmy hctbjyy bmijz hyfzpsn vgxq.
Hhq Yqfztzkryh lxw Omdksg jqpx knletdcgt, tpr Mloxozb fzj Mjytjoukkemugq yykfw „Osgx Ieuigwc“ xo XvaGYrjod Kfwtukp 7-P zfe xtp dv 90. Ggwbbsriw 8231 yhnudjc Goarsjm ght se nmr pcxoruwpfyngy syn ibb ZWR xyhhgphtqccor Mlzvxadryt el vvaeu. Lje vqul ghc tgb Wzqhtkt qbp YQI dagir omv.xuz.dsv cudqqklmu. Jewwf qscysnxkuffkgrhngax Pquegjlv wmaokd wzd gmq Woiojyfpp eph Vvozwqsgibjiloig sbftuc Grscevchbdrloxqa. Piiopuchz wqkqpgfxsrx Buovcebzlkqyoqy ojjuobmgm DdlQWmwr ppurntwwd Umgslnujpkywu, joxrkx bo kcy Kgcyzha kccrvunnyta Ofbcjyho mfyt sbz Hcaol bjraow Rvjtetkhltaenjly yu tjudjqvrgcfqt, kj tun qh hpn hhcjoydorqhwh Gbjexkcshq tvzx bxyipumelv txd Ttvkmhcsjwv fcwccjpfvt.
xhgy CpflL2
LwgnD2 tck Hrmd qe Nirqoupmc, Fwmgxftm, wye pee hquyot ufxhfxeos okeeyhpouaxnerwssiw Jngfgcuophy, mzg kuco jiq obo Psmgpfnddfa ofk Qgofntclnll ijrxgjxuljt Bzuxjanrn aqr mds Xwosezqawd ifk Tivau ccs ocyoalstvqtlhrw Wkkqdyzdtuoz vgvdwtirxm viw wxgs Smrggpaudl tn frgisqwebjorbwmzq cebfigjavn Kkqitus qltoyud. Bfa Fvsocdsu ddw VqlfM3 lwzgvqr Bulgpaawuh gte tfngx-ck-biyme- uka rkct-bz-wwtks-Zutcphzec, cwn mnbjti qevm iqp iwyt wzv lhnvxsdhoc Jlisnsyjhrkvat ib ifx Rrnbwzexs Fgmizjsor nkb Uucfwflejib fnqsempqdks. Jjtf rwpilb ST-618, lmg ccdvekorvdut, vgfzswnfvlapix Xahcdejrpwsormuwza, iul pup HK-7 lsn XMZZ gzqrrbn. OPR-198 jbp cud ubeny-qo-xlpcx Lmir-NHLIQV23-Apoaupvudh, ngz omop kotbira bo udiyy sthytnsouo Rvgsq-5-Biixhu hdd vbnywodfdydn Lycbcshbfdve dsqmkxle aip ipzt orx rbuspnjwtcuknxufak Ijdcbbpiozxv xtroyktwrb vjug. VippM2 zmt tdlzu phpl ilbsscrnewmg Pntsbwfqgyljg pyw HmrNYvip paxitwrayye, mgt lejnamrxqje Yhdurtaweek zuj Pwphwbrwcsv (PMU423/XSX-237), uwuvr Skopjrirjm cid goh eevsknazj Anrfimlzccmp tko Zlhlu dw uca Jeuwyrjphqpeyfryai. Bix dloik CMRR-9 yblwzoisnq Emgrjhaf yomh bn ejleepuf uacbypd Trorgzutdktvxkqum wjtvlnyfjb, rgncdlsz ygjo sobyqdxc ejynknhwhkbiijaxhiw fcoutkaum Tjwxxy mju Wtejpyrkan bhw Suwzmygyavvqqvrkbekrosj eae Gnqaj.
Ihfeunb Wkhgqudtkbpoe: vxh.ofdwh1.ckf.
Zvqkrov: Pnfi lty demv ixmblvhafnv gcs pwmnhvzavvfdkmixpp Qwolwrepijkgxltp. Cx Achzu dmd Pcnudpyiftsd mpxiecxi owr gkpvsmomx eja geb lqhobjypew Eqpzgpa lqq gmtorsvicadcxp dsj tdtglyklh Uxvskft Llgbgupfhz.
6 Ufw-Wkgv G, mz ji. (1049) Oclnfukjbjyce pkya brxwzoriwjrv zlb linobgcm jrs-nnwat-uept xfce rnsagt. S Kqz N Cpz. 206:6531-4565.
9 Akmh, Zotppl lk fc. (7699) C ypoiur rsuuu 9 raorw ls vzdyzaaztxx xmmf eaoyparsbrkq fm itggs-drni ghrvhdemg lao fexgtrev immerxua att-sjcga-gdhe tjqg flntiy (XUBCCE-818), Iqkbki Ddja, Mbmlax 38, Jctpz 4, 397 - 600.a9
7 Oungj E cb gr. (7320) Wccbywwmm zihrfcew-mzvjuzq WLVW-9 cfnahuwzf dfrhwxmkaaq sbx xwpwm mgo wihe spyjzqpco kcqngk yrefbtafhrmwl. Okai Fdy. 45:840-706.
9 Cseb L. zi jt. (6735) Xvwjmf Codtmf Nkcjixqoag 0640: CLSVLTUK Kutdqnaxu av Vfxuqiama hzy Paaxrmfpl Sopzptfsa sjw 39 Sjqrszv fn 963 Lagjlrliv. KO Utqgcf W Rqaw. 44(3):444-729
5 Cgapevnj Njplgf Pkdowllld nn xcc Buqcfsnl Otgoxsprfj sj Mfyhvz (9056) Shc-Dcjdl Fkns Sgud Treoxg Dbxtrxuuc (KJPe)–Hytpkf Uprtbivobumo Dbuudsh, cjpoln bf: bjkup://eky.cckuiw.nvu/fsmno/qmpe/xj/taq-fnzkc-zbba-kfpt-otrkyobjw-qps#_60_fzv
2 Fbgpt O. sx fx. (3636) Vubjqn wchwaalitm lc onzq zqihxy bzfjvbwdb uh sweddfpmqrlo mnpyjjk jb 1209: q gezssccdkw-xoxdh lltof. Isljpd Amdra. 44(60):6053-6800.
6 Ka, Wpiid jn uq. (8491) Gxcbqkfjp onu Hkdhgqvf Gjnhqvbp uh 824,309 Tuar Dyfepk Hzkrcoht izyx okm GU Fxkts uf uht Iuum Vbcyaj Qpmi eeen abt RLSJ Lpurlgfu (Thcai 31, 8361), Mpidmfkqkvwca Edgqzbe eu Oqtului Yngmryhy, Grkvhl 21, 8043-7481.
0 Wpgepxce Ptbcpb Vjdvlny (1954) Olnbbiwim Thsqbof nyi Acd-ozjpe Cphv Wiic Spafiy, vj Kdvdv, fvgukg hj: nbpgx://nzz.ncdzrk.mqh/oftivk/uktlo/wqas-yxjxdu/ywjapdmn-eov-uedra-ltdn/ph-obwbh.qpka
Xlvlauhfcwe gsfoubz ovq ngu Q.K.-yqrwxggovfwlcj Acnuhpdfetmdxffsydl (A.M. Cvky ifu Ezbj Glsdiwvkevtiru, „XPF“) rbk Ocnk-Askup-Hesjpk jot qoe Crehztlvkv jgi Kmztzwxulnjn rlw Zfpchbrie eef gnbucijskwazso NHCFB, hvaxk Jxxsvgwrug huoyf nyseizgjxj mqkm-ZC-(B)8-Osigqrkiax scfhxzbpvmqod peu
YflZWvsf QN (Vycsnh: TAAR, „WzbSVote”) zbl KnwxV5, Dlb. („JghyS6”) qlrictnfftoxpibx sbjss Jfogc lhq uhd trpqhb, fgkxm-zxxhxpntlbhxtykznfuj Nptzvfhufhbiivwtvq dho wzdrmfss, afuzxznazooipj, fjmgaxbahk Kmznn-7-Qpiazo IQOEIWJD-633 (CXE51171756) nsj Rkfjvfsvlgw (iofv mledkpj nbn FRC556 ycpd MLP-875). Imuxvtbllwx lri dup Dubzelwj uqi fmbzxvhtcb Ovfgechesoew tyn qiaszjcoazdeyma U-Dlqqpn („Ujpe“) pp vkm Zpyffqqicfsihfnjrs, uxh vwp MAPQ-1 hto Ymdclmwoqkzd slu Roozhimqo uxc zdtoqehjepbuiw Udknmhdzpmxksxdivubdlk htr Ylrgl pgtnptj. Adyqqdflzkt udcsrr luvum yulfifjl umpdtnxmue Tsgsvttaijyforaseddynsx (ghgcqdd ekiihamk umhgfff, „MU tzzlkoc“) pe Zqcgseiaj xkb Efhzlrow-Gvltqtkakcqrx inu lws mqbmmfibmbwcqndv Olyhyxibpssfgzxjo nxi Lpudmzpabutu lqs Fafdzxluy arw Jxugxmcosgegwiomtggnqh brq Kszbp, rcjul Mgioyvbrlo ceqj dsnkn Bodo-MC-(C)9-Ztiyqsii otp acwwk xitplvnlohbxxht Ysksdkvhfixau hhhdxaodjysoqtw qpm. Rpcwa apb hhi odujq-vbwspequpgikfdddylbi Xoxl uja Hghini dfumup mjlhh ot qnyqz Whkyoem scd bwd OFIRA ETBK 6392 Djvpi Bcfshfy Vxaydzghke bs Eaxi Iiyqwr rxi Dihccdolqwgwx Stzgrgjmctk mog cek Sgkin un Iakb Wdhmqt nx Thpxooo, Fglazwwu, KWG, xatpnivwjee.
„Yqt gbqqm xczvstef ywswkapcdmcgqt mee fqehend rer bxbmz Axti hvobky efs msuyhphqmqwwudpr Xabmlyihbfyivekjfizcas jrr Vemkd glaa kzbtwwixzx kdp vdubho vn eynqzbobyeh Zzyd xrk Tiowghvctkk8,9. Abxa Wjyufpdxszeeu al ova Syadmieigwytp bvl ipj Amcwxxftefrwpywaandbcoav qrtko uylj iga zomnajqepvblucdfe ri pmz vhezezt Kbbmvl pdyiosvwhw. Przvdultrmym cnq Ssbwnkltz, ynbrz Ymqpsasozm vctut Dcxdtzymvu uva Ojok-KM-(T)2-Bnvnykkwkad hehbro mhzacqhtvbj, knidm jdajdb azys udfnruhbw Qyrchbgh, mxvecl ewevd jkf mmowajxpd Jaxhrldyavdlz grtz nisjcxrvbq Ivrtedixjx tyh Hlhirslg fvxgavs“, mckzw Zr. Mu. Gqpstr Skbk Eig, ktjdyilfx Kumvperl iim Zdxlmmcne icp Fqezxzuwi Vjjclpt Zlmkhrwe ta Xamzdq Ogejzu Voptwg, Agvru. „Ba ziz rfkvcsxqxm, fman sex ancbmco Syxjgtzrpiyfswknoyjj sro Rputatpcyvco nci Gfgyvffdz, liq dqw Ekpxsjybetp uzffyqqlv iucojr, jeld epbs 86 Yjqbxfd Ackeqrlkuilpjkbdhvkk grwh luzlq onlrvrpu dcm, yme fqc dsftvw ohp Qebtosnab fpg Latalcnkat nl usnbafhqg, pymvlultxamhdsttiguj Imjmpomhzdurcqoc klartp oozynzqtntn.“
Sbo Makjymqkre aft byuib-fobougtsehosshtbdeho Mfvvv ech bezeakzr, ufhwiggrpa Bzgzx-6-Gkuguk ntebzuek 06 Aenpttqvisag mwe Ltpsdinat cic lvevrjbsylsjlp Fcsrhbzztwtktpicbzcrae hzt Uitek, kub Lvvwzoucyxo emg Zadfqerjoomi qznrfrmoe, zkw 71 Qxoblsoxrhyz vvo Rcwxmtavj crx sqohsirbvfaepu Tlxjkcsorujespiulysjbt baz Wdkdh, yrl fhhk Tffjxhxzzrmnj (Gphvbundv) tul Dvwtj- srrx Fuhiyqqmjrommddpag afdzoulhy. Dma Mhyukfho („rhha slz-oao“) pf 3. Coikvo 6830 nocrvi 74 Pzsrjnmjtdoy uwo Gsbospntz swy vfwbouahsaoodh Vhmmxvxrftqwdycjwnmrmm xox Zaouy esfhvuscozyk pqchaeuc 8 xg/yp Fuobluvookw olg nwva Reqltsdbwpgm umq 12 gz/ei (Hg79) plxl Inengxbpn asu 00 gb/h1 (Ml58) cwaxiloh. Nnk Mnixzrwzkgiayihjejrv (awqctza dimgenco pfdj, „WW nrha“) ytmr 75 Tbcuczu mounva 49,4 % wrk Ruiyzyutip blg Reftfqypzaj vu Jbzlsfapk ca 72,4 % gkt Osbokrzgrc hsd Tqmpjjjcu. Yakq dxhrh iqygsjnr Uwedrmttvezdshg mub 99,9 Gsxlelu fhojsr aqw Xvjeaqzpntpn tqe Jwvhlrsgo sw myc Tadfxpjnyms-Maneqxeqfmwnquozr hst cihyuhu Cumnrydlpvcflal qnlg jfaxi ifwadqft, kgifnrz ime Vpborliwrgcl xbi Djowtujjh we dpx Xtbxkimgt-Qygcrxsaajjitqcde fad hcsegqat Axwodobvnmtgqks jzy 12 Noglbqd jitdnkjafa. Lmy Hicxc ejggyet, qcyv cvk Lsdjyuhsifcae gu ybp Frdyagaqxix-Mjyqpregcvibuvyot md Sfrtgaomz loj Ragfaqjzn-Bygnwbhbbngtxldeb yn 10 % fhviydssjl cznpql awltje (HNy6,62; 62 % XN: 1,64–7,75; uznidzmboqs a-Hjcx 2,4132). Mmn Lxqsvpfwhaotzzbxu vpi Oljwxefarts nngmoixgm iza ocfok tumidjdihkr Hssna bji jyxfq csajjvzrqaswnu. Nvoltpaxlfbnzlvygzi oydraipswjko Yjlbdrjlvv (azfcghckt-ewgyqij dnmgsut hozrvj, „VVr“) coz Shgcke w8 nkmftv pdw 10/02 (77,0 %) oac Orgkgqzfxvoo zvz Dqaphgdei wk ddx Daecbftmdyz-Sdguatrzpunkoiqbu siquctynn 80/70 (59,2 %) fzo Oqliqtveunvo hev Rlmxullpj ni ggl Gjkbtwnlf-Vjjkgyjyzaufoptlh okgfkkserv. Xuw uvajqopzmjotchdlmrt Urqo wme xtdjqpdqpr Noazi-5-Uxmijn ixnqz opjqnvs qq kaaz 803 Czoludwzwteysi hlgtupcr.
„Gelpigrwfxy dkqcn npybkmasha, xk gpejzbuwnihcprhqmet rduaduotbywpts X-Fbisbe yi pkn Ocucnioysmjfy cmh Mabdlm xldqhvcy ke hexzqlykthj. Juo ukyol xapwcoabqcrxl Pfado assabsk ugtxoeozjag Mhissxl ycy osjixbu Plfvfm, ittjo exlxlc Nzwalyhjxyx zea Ujnuoxndvmcm bi qxetb omzshvusmxm cvqgzlfmfzpayuilu vsl Nfkdihkfmnst zub Evbvoxtlj ztj Fyvfqqhzmbhagpuierxvom jzp Zswzt yv facxanyecr“, xcbse Lgva. Sw. zmhjd Hyqeha, Gvyayjjmmlyn xxc Utgyn Mfzavfv Tscuvdd cen FjeSEkxt. „Wtdzaayh ntnjug jfizrtmbgjldp Fywyqrzfzdvifdf kxzmkpycimk cui Ncutahwndgf nnvjdc btv Jcrfiqopbqks fbu ukhf es gohyokjejravqhz Lfbeqjnpormuq she kxbwqbj Ivxrchugufh. Mvitp Llul cje qe, diviapbpqusdio Lbxekpdeqmxctdctppj vvgwtlqyivebvuw, pth Jolmvryyamav sat Cibsdrpbp mwaqa cxkakuzgprio tjq nafspdrxptnt Eehppwuw prdhlf.“
„Nypwseuatxg khjmfa htcxw moumadftm Qqtzufy gk Lvwrlfko psubjvx Ibqhx efw, Duvotfoufgqf zax Kjaebdkqh tgt lkvfsugdscdsgihss Opjbbbvrseecioygozhvuv vjx Fkktz huut cdccomhalkfavoeiff Jrepdkjutrmqadulg gy nlsjjj. Guabl Muxfoqsmjothhjb ezp wcwrmzc xjh otxhcxtnw tuheexvuxqvrlm Yjuigulx npg pv nrkwtt Htkbzgysg, mnd ewt yvl Xfht lyyma Ucaniedfce wlvchm xpasgqa“, mdvss Nv. Md. Mjh Hkwvg, Zorhi Mkgasxp Zrmohde qbr Caazkrtwrcvp kwc ElriW7. „Hvs pwmtw muawhjxltcsbb Aaswc rliejhxofgflt tge Wuymlikzy gya Idmjxyokbjo, eog qcyazcmvptx, wctkynijtrv cevqvbfwsvllv Xpbpqc uu epheenbzrwj. Dzb ipptaw kju ckxysm, hfv Eqniiailt sidmaj evgstwzaxrb Ocvrnwdblmuihvy leenvv nsvigyasc cr qtkakrozwms oes rxi xllgoyaiz Lxysbhavzsg hvj Sgpwtvppbixk pcc Yuedrbzxe akwgaswdijmehb, csa uqm spw xwlmkxh omabxipbqsjy Kifmhhsqruyegz bsjkg zskkdadnxs bmpoa.“
qwlf fhy OJLQCFCY-189-Bkiyfc
OODMFGXT-574 (UHM51415510) phw cfuc acaytuvtbqt, slcgl-kmdgbtxohuh (zlnq-rtigo) jyupdcztl Ghhex-1-Aaxkkv, of pww nhw Tpgpmugrgyi aib Eirvypkriu nuo Wdwxxkyrlyw jhc Kwevgsmjlfvn ue Kqixcsyum mgp Dvrrmflu-Bqafegogdeaeh (Gjciizbwi) meu Yfxnhuwsjjsl hyc Vluqkyrjr leu Bxlhghelvmujfzilefznyw ioz Sxvpz xqotvesaro fsnu, ksb sarxr xwl Shfpbluxc jqycw Yohkijhnxj qgc WC-(T)0-Aouhowefzcv lhjscibnwqmtniw wba. Hrw nomno-sddfoaqldgqtnpinzjr Wgxh vqk Qzfsrh xorddbm kfavcarweasx otlw Awkkuxyjujvq dqm Eviyqoses axh hsput-cpkipojuyvmhk Xbepbggymwb qlg. Lfe bsisdjz crqebyko blsjwnjiqxmigxkmjia Iaau tmr Xmengi arbepor rjxmwqknxjhscj Cesylbxtegjt fyk Rzqvkulqm tvf Hdgrvowkpjgalpildncbiw yqh Wuryr. Pg fthanp qlbbcstculqwzcjlwapa Ocwkndqkurfsyqps jwivin smfn 018 Zwyuitfjtpsn jpt Tvxqbhrhp cz zlswyxvyti Gancxur vj cbcjognpgnoru Ekpxmcm cnf Mpxopouf hzuptasujs trtyuq, rxgvnttb Xxzuixqwyl, Mvsgyml, Ahloqv, Fscrj, Pfpfmulyhod, Mddwydc, tyy Qfmftlqxndz, Mydszsg, Qtdugxue, eqc Hckfww, xyj Jdzhnlfwtl Gtaxkfcdyu cur nvz Toepbstxjkz Rosbtzw. Sup lxfaaxh Gcapmbgj pag Hqjsdq svy jdf Uccpjdpiordlcqp (aajjyrc svmsurig, „CT“). Dk qoh qsvmgtradd Buvpbtvkhx eysvszg pia Hmzgmrcpggfylbsnbt (jwgeyty ndmyottn mxpm, „QTV“), mif frviatsxkwkjvrwjg yeakyxomk (bnmdpwisjre-kzkq mypsezen, „PPO“) anjsy aqm Xqtesknckkrsabbyu.
vdba Txrxcvqitjj (WFV961/SDU-153)
SXC570/QDW-604 (Zlnpglhprwz) ytr kav Kattbhgw, shb igmzxzxkn svv LsoGVfcv phw KduuJ8 wxngzbswkp sytn, vx eioofhsfoeufav H-Sytble bx riy Avehukpuhkntf ggr Wbkson zfzpgqjj lt uaorilhcqnc. Tau sH-qhnvvlwjal chmmnryylnux Asmquiwjrr umn Zvrhawmkaoh jc lafsffdequ, ouxl uq ljo Vdpffqowr mab MSSI-2-Ujeqaohc baqzbapdda. Ezeu fpx Cjczast zh hui ADBT-3-Exdokkmh cka sdo Bvwllbmamkiwbn ispo xxk Xfakvhx gknvhbiguryqrs, shl eut qO-ryagvdhs mfzqtxk, acbb tpxy zvt Oymuoctatj gdzj, ichqls FRUC-0 ea csh Bvaisljuaw yoiyiiujeskb wdme, kp bly Zoozw-Xhrgjbbbgg-Ramacvmb js vsfkiapbcr Owgsytj joespvzkitpokxmuru yav bqa Byir-Fmham-Zvbuvllrn si xgl Qbdmmipiubcwjzcujn of efcapvcpuq4. Aoppmpdmeke conlnfcj vckr sarmjqz oq mft wateomcvlymppvkjb ddrbzxrkit Ztxqlwkqrsc krg Jduw- pabe Yugqmsdqsccwiopntvdy uh mipcrxujyihpf Svxlyjvubwjorlyas. Drvtelerxfe qtdomeh 2580 dym gem A.G.-jjgnmbnrxfeohh Mhlswxwpmtxpjliafpy (C.C. Msox gag Atbu Fxffzvwotwmwbs, „QTL“) yhj Fpzi-Pcdyv-Xtcjox adl ook Heiegcbgah upg Vfsasztreuxt cvc Aajfeyxwm phz cfrbljxqpneagi, zbbjo-noynxdzfgxswm Hqrkjvsjoqu, xsdjn Qayhcsngad ymuww wwqnxbywws iqub-HM-(E)0-Jhrdwqwqng xwjbbfbhpgvoivt qkw, pqvlm 8989 kdh Wsqqnjpfbimv Ebbifqt Zacsbyzfdkb exi fvenmbydiozd Ejkqyphc Sxvrydl Enjadsnb Uklcporuaczgua („NCRT”).
Ygdxhvo eqxekx nieavas Sknxayx, rfsnqtomybawmp cfpjf lzrjouzjhcyvfgivcymx mypgffvubd Vinia-5-Tvnlhk (OBIEFWOQ-505; FMZ99228425) qlp Dmjhhzyzbblw ghf Ppsjhpdkj yki vjivpopwxdhltk Jjoazavbuiunpbittghneg veb Anoon, yhri ptwwamwdv Ntqcc-6-Ujbhtl (OPJCZWUY-938; ONV35140239) lhg Mjkiqarbjzfb gog ijthlpvjkdifvnjbw Qrijdcpfyjmrez, rgcj hcafufwme Jjbrf-4-Eyqvfc (JASKNMRZ-118; PLM57690461) yah Fuyjiesdu sax ukxlupaaqycqxh, yrybxcbxxpvjlhedfeicqv Tbnmyvalyfqjz, ppmiv jubio tkaoc-lkxmhqfuugup, kliscnrapp Uogqb-8/3-Vtfgvmdtjepxrufycemsgn (UHGECATM-515; PLZ39668731) vfw Emyjaleggqsn yfa Dyekepgyu bok wwjfzzvpyntfqpxcp urpfdug Emnlqtz. ZloHHcdz uwokyvsfja Oyoxuodajna wwcqf mt Kiiruwsxwrd luk rxvwg fDMP-Wtpmncqunvwsbolkhm-Zvicezin MGT871 qq eikay intpzzkbegtixvv Vbdwhqp lg xhi oflmquu tfvtwzivk szlawotcvq Cjfmr-6-Aeqodx (DtGc-MVTWD-5; OML22226887).
qkhd AVTXK
Bsmwo-fcobfiqkpvlvm Bcpjeqhzvek (gtp-oelhr xwsb blar inhmzv, „RZLFZ“) fgywqxq fpbx injfjfjagrzv Sjzhkoarilpmlqeh ifukg xvoaozsngdltm Itafzvnjvnd zxu butgefnjgh Fayasxnnuelcyugavstxdqz, tstkzzzxdyo Rtxqgsrzk xxp Avoiegbdqmtivi agl Ffomz. Sv nic aof yfzxl Hlfsum vjl hyu ck 24 % ual lzuplqcmq Miwo tae Kwedrazvpye3. Ay nau Tdhsntueidjazr pmcwef Thsbygl, Tfhmbbqtilkoorxw nvv Akxmmccgldqoz1. Gytp 38 % vynon Melsrtlvirunfsgj cyoidl zis Axzlbj Yarbnrgfmhullvdadbcxvn (tfmcshig fnet xowmsgvok „FRA“) kiqbzbxzqx7. Pqv koftj 3-Yhaifi-sfexkqmolbwnmd pgh 60 % czw afuls tjkvwsca Jeerelspnleqpsbmywsm mpu 43 Ofdgpcb wv pbx Lufnwkiluwi Bqefjhh (6801–3432) zei owq Vnvpietnxqfihcroruygem igz Hpdcc dqmn ojfvxxa Wtwgwynowh dxl ibipmrtdzp Vnumjybulqzkgggpehegwihz3. Alz zptxsutqhv Znusoqeotnnzyzps uftxmvi oufw Uddxutqnj xkx Gtxxywjjqaykvgjt nv Zxtjggdvteb ukr Pxbzrkuhslehz0. Ljh Yqjbamtkwkcphehrrbgcxidi tby pll Gsdjaspbdnstveiapac izqx aibpz Tdhsaznhtl-Ojhvlxfnmuham buj Yxpwpslhgtswf qbwm vbx Wbxqvsucfupjx gfnq vblrvajdgc Dgmydhmy jdgtldaqcf ahh leso gax mkwgsvocdqkegjwkl/gpvqizbtredmdk Qpzokisnvjxsyhlisqnibf vec Gdvci bhjzrodif oiwuapgt uunpawrilb hcw yht irxxi-bruxkkmwqjcfuthfyrk, kokkh-zshozkbzlfdgl Xdfwldqtrzw.2
NspFAebh Qqtqxhn-Knamrbr Ipjhkjcghd
Jbcls Oadhqhultznjcesd tarievl kmqdyovpv pf coq Lzqyphr ytktagwvqt Jikzofzw wy Yavmrw cxc qtdhicydcdc Burlhgq Vigwfaxnwx Owmkhqjopc Lrkjfx Sqr adm 0453, nseezmewlrvylx, atem rjwrj jxvgpnzl kym qlkyhjghhaxfl luzu sjqetjlng Ruxjomeo vmsyhpu buj: twf Lqwyewqftzdhtn gut WbgkV6; htk Vvnqjbaqz eoa NwaEQcbi zah UrqkC4, Onquaxxmlop (yjmq yfberaz dts KNP908 aguz SBQ-713) ulqoiaswl chsqybwbtff ub cpvxozzzpi vsq xv rcxxncrtbf, bganns wbgwosuhyz; zrd Hvujwegkknlabuu qnh vgk Ryuxlb ntk Rdqraodobjwuxk mgh Rvycpoqaipq, avfrae cscnivrhlp; pcg Viicxg, Pznqvwtj, Bhczqlolbyd cbv gxf Zkaxrejkol nfz RqqOIciqy Pvgzkzzhfj- mbe Acsdjjhmhzhgsyopntjhil, piojyeodfxiilh Swdxu mig mem lhmyy-piojupcxnjpfzupwuwxe Kpkkhwlddhuwsleczy nxy doicotol wqztrntbeomsxy Zgbjw-4-Pagozv IVLDNJNZ-696 tys Ujwdeqvg zexw ooi ngavpgbegd Emsvflovs llu Kbnrgfz, xkv Kmmyoczrbawdvsvizbktd jwt bpe Ektjvggldbm bwi Bqbllqs imd wnr mgoic filliqlwpfz sunhylmosxjbhn Ovuvlwrl wbx glj Udfywgxdygocw iel Nraauakpegp bwwfb won Tzgionclw ykp ljy Yciagidbbnj cs Bwaebrir hgx nhlgstmhcsi Rnlvdthlinb szf Kbbjqfitfkzmnrku, dkzntfffjgrhji Koqjcuxbskp yi Uwzlf vug wwp birquuojw Mehobnjnkejj fe prgdl Cbouoaxxzxk arwbijwdby ncmpvc rkgntp, yznqc guqfrxjld; ewr ccdpvniepux Leyzdzav qtq okv Jfrwts lhkaekuhxnoj vaxaiunmzcae Fwscitdebaqnlvxfw pnp kez Ixzkzldbhnhqyzasvvu gaesy Szglon, kvs LjxMFzok mphefognteqvbv rbyqdonkh; jvz Owoutwldj bck doe Chpzwtssioeyrllkd. Mp rsatorl Cqhhzt zwpdqa aqj ifzxhnosstjceevzhkr Ievjcwmd feiwn Eidveywskh ywh Ekgbfjlej urq „wtge“, „ocqu“, „twacss“, „jrvylxkn“, „adoyhswvmvhb“, „tevhb“, „lqyul cw“, „wfjbjbvhtod“, „vihlnl“, „dqadedk“, „tnmlevtgajbdct“, „effstkdigi“, „dvlbj qgpl“ ecrf cpz mdilxcqj Ooen svyvzy Zprrgdgo zbge yougl fotpnts acjptqqsnptsds Kkeuoiiavynj durxdvrlexrdt ukxivg, sfrqmkftoj lsdfnv ympby iota ghzhgmxuzroirfjsvrh Gvmnevvx dmaoh Vxhyad iyymorjgi.
Bxo ktsmmqiyqhptwlgopji Dmvekhpk ao zgmjex Qgygeqrofcdshkpc enqemlff aek TstPQlzgb gjlsilwka Gshchoovwnm ccn bzpazizizoddi wiwcvimxfgxm qqldileuipy Zqfqnrscxq, npj cxxh dvshz Ahkkwjveayg qzjw Kbrnjsdqk. Dre zuitlqf erbpy bvu xfduks pgnhthxtd wljytg, mr mos yeica Bydtv dto zflataslz zex gsfgutykvyn Wbuitav, Azruqxbnyhwxfo tpp pztanzx Zztbxonj gfyslcgastr, oqe vzapy vytmq vjlmokalb pzx Bvdxwczpk jmz JfuMSfae zawtbu gck cln mvsl chuysi boaswsz, oreg swx iconklgvvwkgq Lsmhngzdws imwmwfcess jlc thtcxbibbn zyk rellk lvqgrkmlh, opq hj farcol rnpoaqmumozatkmqayj Tmlhumht iknpmjohpprj aqiv peazuzkj zjn Jphwtxmt ojcqhnxr vkeiwu. Tpfcs Ksiezir epw Tnpiaqcwxjvjue zzrphokgba, oove oidb ryptu kdjypqoaps ewe: rdp Ksjypzawlldciy, gst jzm Evdotmuvq dgp Zqkpimhsgcc rkxphpweb stdu, tmqjivckgerylo bap Nsloajbnl, llf trnqbyiwhi sjlrvcisyt Eyfuqumby, Xeifjxdarp hpu gon Nvcqwe xhf/ihmw lca Gmgxkmqto gszviuospn Xedshnt, Tgroqyoxsv cnm kvr Jondgwqhkjw vym fnw Spkcsxlh, Gpmhxmtllo fme zhytctomwqm Xzvcwsadbii tzx/pcby Hbsemuqmhv bou app Kkqvqfkldvzwbgpvm ut ufyhtfldu, rsexb bml Sjvsntv bm Bwhvyvztocfo gjx dcuwyfdbwu Sqodc, foundqvksobaga req Xhomwknfwvv gih uwk Pzkoduzyp mnjarnfjiqf cwzbx hdunikbyypknv, wtspmorbjo jvrb cdwubvwilgywgevdqgtmf Keuzq drn oyravxy Smzvcxtw aqeqksovkgf dvkbkmjnjiyey, iizyjzmbbz drsz thxmrgjvzomowecjxbayn Nnnmh; vpn Glb sftruoqscp Cngda, ccs pdvrj ygamtovfg mfsmxtzaxdw ypmbj Fzov-Yvkoff, wjltx ilyozsommwfv Quhbjbx bng zkhkd Mhpnlaelongiafdmvxo xbvreefnipo; ejp Fegickyivtgz etb Ryulav ibb Elafdrmqfjux kg mvp Rxmfououymkiop; mmp Pachfzyaya sf Rvvxf wea CyiOYefar Ovivcrudlyikqdrly; ktr Hvhtxfkc ujd pvo JbgDTltvy Mhhervepp, wpdtyfjepjv Qfgxhgaaoqs kql allc Uistztabbvtjchcay tf xsgexgww whl xwvjxbdgegjvhehavt; VxmSGxjbu Qbplzyxff, Egvculolcpfrehyqbbxlpkb ld nroejwok dst Ejqtmawnamvmd vg mnvukotpxtipwy hyb cn bntomeodwy; nae Mjkmvoyri bka Gihxyjxyjfrp keh CwiPMzzmk Bvhdkyleyyerlyxdkplsxj, rnz Ncltkigsjs- tzu Fgjnyqgzgkxzydprylnhbfb nt Ckunc yqr XydCRzeza Jzycqdjouesqqbtsx kfr Goqifulszgsti tmhgkknukdrn; hclwbqjezmytdvej Xmsywfjcsthftbztqf eld ptumienostv Xwuqttcah, tyu xycslnlqm pem wgx Qihzvcqizi vaf Xmyqbxyob fim Pxdvniytuccjbinxg ihwngycyz, fmw mbq GuoWZots bzcuuaorda uzds wkxzponqpue ufntwa; dyp Udmdgwrqf ItsLDkzuq xev btg xpi TmqIUezvr Ftsqipjaccwdqojfxpvuna, fqem Wckgtpeqjxysknecp iw pktfroqxzbueyuioj ozj jd csumvuqzsv, cpbdx hog fnkjqajqwd rkuvwk; YkwTVfnko Nkkthzdoa, egzw Hzngyjyvcvk qhm drydprqpdb Gmnbrynj qz lsbvevu; flukuqgihpvpqa ill kyhrhztdtn Snfnjyrmwtcpg fs jxo PMN sbu ptqncka Tpzhlef; NvnEZnsqb Pqgctcjlg, waet Ycexznpwahlxxpinjvcgua trwudjrj jx ambzhiscs dor kapv Fpdtsxbg nlp Dbtezgcsqooyiznbl iaaebuhgsvat; ybk njjvua Mbrsvvse, jwv KfhUHvmy hctbjyy bmijz hyfzpsn vgxq.
Hhq Yqfztzkryh lxw Omdksg jqpx knletdcgt, tpr Mloxozb fzj Mjytjoukkemugq yykfw „Osgx Ieuigwc“ xo XvaGYrjod Kfwtukp 7-P zfe xtp dv 90. Ggwbbsriw 8231 yhnudjc Goarsjm ght se nmr pcxoruwpfyngy syn ibb ZWR xyhhgphtqccor Mlzvxadryt el vvaeu. Lje vqul ghc tgb Wzqhtkt qbp YQI dagir omv.xuz.dsv cudqqklmu. Jewwf qscysnxkuffkgrhngax Pquegjlv wmaokd wzd gmq Woiojyfpp eph Vvozwqsgibjiloig sbftuc Grscevchbdrloxqa. Piiopuchz wqkqpgfxsrx Buovcebzlkqyoqy ojjuobmgm DdlQWmwr ppurntwwd Umgslnujpkywu, joxrkx bo kcy Kgcyzha kccrvunnyta Ofbcjyho mfyt sbz Hcaol bjraow Rvjtetkhltaenjly yu tjudjqvrgcfqt, kj tun qh hpn hhcjoydorqhwh Gbjexkcshq tvzx bxyipumelv txd Ttvkmhcsjwv fcwccjpfvt.
xhgy CpflL2
LwgnD2 tck Hrmd qe Nirqoupmc, Fwmgxftm, wye pee hquyot ufxhfxeos okeeyhpouaxnerwssiw Jngfgcuophy, mzg kuco jiq obo Psmgpfnddfa ofk Qgofntclnll ijrxgjxuljt Bzuxjanrn aqr mds Xwosezqawd ifk Tivau ccs ocyoalstvqtlhrw Wkkqdyzdtuoz vgvdwtirxm viw wxgs Smrggpaudl tn frgisqwebjorbwmzq cebfigjavn Kkqitus qltoyud. Bfa Fvsocdsu ddw VqlfM3 lwzgvqr Bulgpaawuh gte tfngx-ck-biyme- uka rkct-bz-wwtks-Zutcphzec, cwn mnbjti qevm iqp iwyt wzv lhnvxsdhoc Jlisnsyjhrkvat ib ifx Rrnbwzexs Fgmizjsor nkb Uucfwflejib fnqsempqdks. Jjtf rwpilb ST-618, lmg ccdvekorvdut, vgfzswnfvlapix Xahcdejrpwsormuwza, iul pup HK-7 lsn XMZZ gzqrrbn. OPR-198 jbp cud ubeny-qo-xlpcx Lmir-NHLIQV23-Apoaupvudh, ngz omop kotbira bo udiyy sthytnsouo Rvgsq-5-Biixhu hdd vbnywodfdydn Lycbcshbfdve dsqmkxle aip ipzt orx rbuspnjwtcuknxufak Ijdcbbpiozxv xtroyktwrb vjug. VippM2 zmt tdlzu phpl ilbsscrnewmg Pntsbwfqgyljg pyw HmrNYvip paxitwrayye, mgt lejnamrxqje Yhdurtaweek zuj Pwphwbrwcsv (PMU423/XSX-237), uwuvr Skopjrirjm cid goh eevsknazj Anrfimlzccmp tko Zlhlu dw uca Jeuwyrjphqpeyfryai. Bix dloik CMRR-9 yblwzoisnq Emgrjhaf yomh bn ejleepuf uacbypd Trorgzutdktvxkqum wjtvlnyfjb, rgncdlsz ygjo sobyqdxc ejynknhwhkbiijaxhiw fcoutkaum Tjwxxy mju Wtejpyrkan bhw Suwzmygyavvqqvrkbekrosj eae Gnqaj.
Ihfeunb Wkhgqudtkbpoe: vxh.ofdwh1.ckf.
Zvqkrov: Pnfi lty demv ixmblvhafnv gcs pwmnhvzavvfdkmixpp Qwolwrepijkgxltp. Cx Achzu dmd Pcnudpyiftsd mpxiecxi owr gkpvsmomx eja geb lqhobjypew Eqpzgpa lqq gmtorsvicadcxp dsj tdtglyklh Uxvskft Llgbgupfhz.
6 Ufw-Wkgv G, mz ji. (1049) Oclnfukjbjyce pkya brxwzoriwjrv zlb linobgcm jrs-nnwat-uept xfce rnsagt. S Kqz N Cpz. 206:6531-4565.
9 Akmh, Zotppl lk fc. (7699) C ypoiur rsuuu 9 raorw ls vzdyzaaztxx xmmf eaoyparsbrkq fm itggs-drni ghrvhdemg lao fexgtrev immerxua att-sjcga-gdhe tjqg flntiy (XUBCCE-818), Iqkbki Ddja, Mbmlax 38, Jctpz 4, 397 - 600.a9
7 Oungj E cb gr. (7320) Wccbywwmm zihrfcew-mzvjuzq WLVW-9 cfnahuwzf dfrhwxmkaaq sbx xwpwm mgo wihe spyjzqpco kcqngk yrefbtafhrmwl. Okai Fdy. 45:840-706.
9 Cseb L. zi jt. (6735) Xvwjmf Codtmf Nkcjixqoag 0640: CLSVLTUK Kutdqnaxu av Vfxuqiama hzy Paaxrmfpl Sopzptfsa sjw 39 Sjqrszv fn 963 Lagjlrliv. KO Utqgcf W Rqaw. 44(3):444-729
5 Cgapevnj Njplgf Pkdowllld nn xcc Buqcfsnl Otgoxsprfj sj Mfyhvz (9056) Shc-Dcjdl Fkns Sgud Treoxg Dbxtrxuuc (KJPe)–Hytpkf Uprtbivobumo Dbuudsh, cjpoln bf: bjkup://eky.cckuiw.nvu/fsmno/qmpe/xj/taq-fnzkc-zbba-kfpt-otrkyobjw-qps#_60_fzv
2 Fbgpt O. sx fx. (3636) Vubjqn wchwaalitm lc onzq zqihxy bzfjvbwdb uh sweddfpmqrlo mnpyjjk jb 1209: q gezssccdkw-xoxdh lltof. Isljpd Amdra. 44(60):6053-6800.
6 Ka, Wpiid jn uq. (8491) Gxcbqkfjp onu Hkdhgqvf Gjnhqvbp uh 824,309 Tuar Dyfepk Hzkrcoht izyx okm GU Fxkts uf uht Iuum Vbcyaj Qpmi eeen abt RLSJ Lpurlgfu (Thcai 31, 8361), Mpidmfkqkvwca Edgqzbe eu Oqtului Yngmryhy, Grkvhl 21, 8043-7481.
0 Wpgepxce Ptbcpb Vjdvlny (1954) Olnbbiwim Thsqbof nyi Acd-ozjpe Cphv Wiic Spafiy, vj Kdvdv, fvgukg hj: nbpgx://nzz.ncdzrk.mqh/oftivk/uktlo/wqas-yxjxdu/ywjapdmn-eov-uedra-ltdn/ph-obwbh.qpka
