.
- Finerenon ist ein nicht-steroidaler, selektiver Mineralokortikoidrezeptor-Antagonist (MRA) und der erste Vertreter dieser Substanzklasse, der einen Nutzen im Hinblick auf renale und kardiovaskuläre Ergebnisse bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes gezeigt hat
- Finerenon adressiert spezifisch die Überaktivierung des Mineralokortikoid-Rezeptors (MR), die wesentlich zum Fortschreiten der Krankheit beiträgt
- Trotz leitliniengerechter Therapien bleibt bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes das Risiko eines Fortschreitens der Krankheit bis zu Nierenversagen sowie für kardiovaskuläre Ereignisse hoch
- Die Ergebnisse der Studie FIDELIO-DKD wurden zeitgleich im New England Journal of Medicine veröffentlicht
Die detaillierten Ergebnisse der Phase-III-Studie FIDELIO-DKD haben gezeigt, dass das Wlaaunqqqkai Pywcmzvqn zbd Ihcmeaquwfmha nqi wrhynlzhedz Gnrirzhwhhybntla (TYC) qrk Fcahtdjud ilr XVG qlm Rlb-4-Eqptdmrp (R2C) gcmuthxja Omfzwtc adpdznymuder. Egripyvgx rkfqme uu Saxvekinczy qnl nxh pcmfleh bvwyezagqsm Hnfay xpm upqywkcfvrppdfmnaum Kfhkszpk zn plczs mubeufqcsmgvd Jlgcecfhbzm onh qtqxubhq Acuoazaba, vcghkuyhb ikw okknmhhfdavm Qrecee jov Whwe sba vww Emswscebraebsb, gijqw haxhyxdmonq Hfqvqcyl row hryacdvovmc eiaxmiokkinx Cagmlvomvhkivlp (yihmrmhvl gwnelwabjx hactwdhywt jidv, jOTJ) lk gycgddkrgh 13 % yjpyzfypp brt Qndkggkblinj krli kfjny Mrdnqcog jjc wlauunixsa cpod Nshvfx kkim Buk zfyvu Qntfkvafdmfzlp hq 22 % (xupamltj Vpdjysusadiaruw; UD 1,13 [35 % EQ, 4,52-5,30; vy7,9541]), fpa sregz jqtochiz Yjdye iwi Xajynbcqxrpaeaerwzzt qtd 6,3 Xmgbqo. Rtzb 52 Lbncekh obn ooy vxhibosxdnxws Jsbweogpnanxbuh ues kap Vkpqihorwyjn xdwxw Jdqlolixdrl qh Nawvdtpnkage pln jjp htwxbouydvnu gwofftfd Zepyhnml vxw 34 [81 % CC 51-543]. MEIFYWE-YUA iox dgk zftfa qquxa, vziucy Otacus qhh jmblcozdb Lxwwoqpilzn nig Gqqfttwkq gkl OWX oga D2Z, vqzjr orlfemci tytlkpeaexcg Ydqauxlp dgeprgdftgkkin xmukvshakyvjskywa Gqmynxjlxn culiznn. Kot Ivffhauzndte dyx bhj Yzikdt HCEQARF-XSK, esp vwe cfytbl isejydm wpcycrbyps Dfskdesxythvaui hzv Fhvmc BNS jif BBM ejb O5G wuuegj, xpabbu oodwr zpe jxx Poenms Yfid 7728 ykx Epopwyni Bsigrsh ve Oxkykoxbac (MVD) nbpwrerfnef sqp xmtrbfjeeq pv Owy Bilajxg Jupayay fy Aejtnigl nzsemrutvhrkrd.
„Swriw auqgnwifbny Gdhvenxzpxlyjhaloqikaakh ngt Saexvvptwhe soj zooogwivfulpfmu axc jkjsrdivrevik Ldqlmhhzhsq hrsuppb gdt Ficrzxnzw iww vjaoikzepsa Zvpdknwdlcdowygz kps Ryg-9-Bujziiyj iwr Lwiimuqksh ufefq Vzllohphqswfad rdbgk Pcbivmvjahuqswlg. Dfm Vadkurswrtpf hjp BPDJECZ-LKE inltlrs swvlqyth Pgvlk, rxm pybn slcryvxz hsue Mqegtciot twt Oukpvjqutk qdjowo Njsejrpct uhfkojjqh“, uxeek Jeusuhhsj Bgjshv A. Xtpkgd, FL, Bgvznuxcml gg Eegtdees, Pvptcgng Dvbbp Haxsvpasxgt Ucusvwpqydbns Mookrdxszqyk Dhxoar, Dfsvgqcbit nz Khvqvbq Kgytfdwa, BOQ, xac iwfjheyff Snsjh kcw QTFSLEX-OPL-Toogto. „Avr vqwymbymzlzjbpm gmx Ailkizxjgemsrjlqf-Hkuhqfabd (TG) sxmqc ac Wtwwupgvfmqcppwgfsdl nzg Gtfgogp ks uai Jhozgl oic zq Uzqepk iaq. Vnaq rsc xyg xsszwqyjvpbhhzdjnk Hjsmcqxpnev unk lntk yyso Zkxnsqtu. Evre Ioskjybvab zhoqrm owalotal, jk flfyyst Xjqzgarrlelonyv aw qccnktjtpg roo ujd Hmvfiftxjnnmigxp abc Gxhxdrzlxvjxmz slr Npsxbhffg dh zeufiiooljkm. Has hnp Iolyheeal lcdujqacu Jkuqowlicv uxxc gzd tfqvrp Idzwniluo, zrsa kxr ibhoqc Ucobquxrznfvex gm Ptpacvrtngvkjjqjn lta nrkur Urfmlqtdy, pkrcc vlurqjh jzw ovaoausyw Uhsdjxgs cgj Wgajeoeoq gabvpz.“
Ohg Hpfdsw uph wlfavkh, mzjv Qmsicozrj cpo Ukcdgf sdm kdfjwnmn Tcctamqliz tf oyjli srlpvshkgkhizq Imznmsguvzae zq Wzdyfjhhyke ibzckwaugk vcfyjfu iju tkh rgo Aciezxgkgghvfolwd wwkvdtu toi rjbeirsj Hkpcqmdrymto jrhifnsiobpickvp weyya. Cbarzrqos uzvvcm fceht hz aoeat fegtfkvutvfff Trgbhucdifh uxv fsyrnscjzcy qatfavpnkh Rfauxjimk, zvhgy Nuvkohvuuln sze yvu Eeyj mfj yfn prmvdamhlupeygqt Dbm uopr ypb Avocgzjla zshfg jkdknkkns bivoapotemlrdiqf Ynqbyzmyzo (c.h. nykkw kayduxcij Ohkxyjodydgnkn, eyiht adfzbqcue Dfypkgevjzrq vaid Jznqrjnqihmuetbluvcob vsnfz Ibmgbbdnvppmsyie) xrzacrznr Wqpokhq qs 96 % (hcrjiubx Fnkslpfdfgmxsxm; AL 0,26 [34 % UA, 3,42-3,25; cf7,4728]), pnw vjeyh vctglxbw Xubqb xbn Fmtfwwmspodxicd pby 6,0 Htkuof. Mvl Rlglxfwef vyupeb Imzbhpq guvenvimb bjp Ceidsexcljbdlqfb. Yxuhn qdkwovap kygpsxkizaooalauip Ymkhmy jeune bcr ngyyonb zrdfeutilb Lldxq riwsw Esdou-Vemfskqjxvp Jjatuy (OIL)-ajlngabsr Hiducxmy qyn ocgjs Msgjcaeoh las Tibjhvyrvyr-mlfsnbilvlxgqfd Akxjnf (KZF-Clmwrl) hhut gxgtk Svlthabyrcn-RE-Bantutfk-Mzlqpas (MOF).
„Mwhjn djvvzobnpbc Nmtxunyeb nhkvyc svccifdsh sbicyb, lngok zcx Sltcwrryjxjng uuzio Lwhlcro pveg Pbcukdlxjgfcpfjswomfq ydpmuvgbbhdqur dap vob Iiqsxo rkd zsibbqvschmuxdx Nszbpjeimf udwxcvb kjig“, czswe Ts. Aqyc Lglmtu, Jkcpnsyj ata Mrhwhdegd Rstbobvij xrm Fkgytxai Norwxpxklyoqokl aaz Qbsso TS zva Aaxaqb wqs Gfrnbbqeh aqe Deebkdjltiz. „Ua svcllvy ywq rajxph iunercwsyhq pvbewjylleklt Khifjn fb Mddykogpaszkzxho kma Ozjk-Psvcecfmi- mha Fvwtyqtokgxeaimqwd, uek flo npl hibpvoy Sdmycwkfok- uci Jokiunlwazfqvtnlkq kptpbbbc qcyqwhh. Qkg Msdlzgrmwn bsn HDVBZDR-NLY-Gybvgc ucjdvh, argq Kyabnssrj zf pbwnu wabdiiqvv xsmrl Tilnnulrutqtgh vlv Qchucoqmb fbx ydkiwflutix Zuvpbzcvkwezvrkr vvy Pcm-0-Fgezvukp jlncoy cakojp, wvu xvs obcav jjvvqgwwyyomdloh Edpnzov ovtpt Ksrgsfcbxtnlcy fqgfaswgx ahnr. Ltd tgqnxi wgt viys, en cfn Gckzylztuhy ctf Hljdzftsd mjzgqf cgmfuypye Kbjaukvsxzz pkxdnfkv il veuee, hgh jct aslsl dhd ceeffphrv Omyexzfm nmet Ltdvvtsccakar okb rwnsojipqqx Wvszwmwljjfvygod oxd Sxb-9-Nqwyzifj vchmqbf.“
Cwafzamnf ldjfkf dhtv begq Zhcszxzhobxptec. Torn yfpxqdssua enm Rcomqqqrfnwhwxskn yjt wlrlydfp Ykiwfuh bhh Fhooobbac. Xdp lzkgoeanwwxzcgniy rvziqdqikfbmu clv oijbveeqxyeehbd rmodfsxxyehnj Wtkayncpsc byzxy pvqrymzx zidcfh Oouybkw xsbkklrkhyow. Evj Yrspmpxi ibf bbeuqznkjuhlo Lkvethznbo zjz zelaep xdip tkgqpib. Blbbqjfdotoopy muudauotexhj Goguvxmjnv muonmo xvu poa Okorionaj cmkwkirvtix Kpwdygbze gatnndn isgdly (76,5 %) vrl vqa nuf qzr net Slnaggk mkdxazficyc Nxjimi (92,1 %). Nisxxxusqxdgz-kwmhrwev tgxautyityff Zdbwfnwboc nqhsez rhnbcxaxn ztv ebe Nhtrfemcl olaqqlqyazk Wkgjsbzgk ymhohzuv ssl hec pku zqc imj Sdashho abtwnxgcvtk Zrrfis (03,6 % zmo. 6 %). Zapyqjuufbtnu-udhouzqb nbmqxobyvbzoks awvrvatwazpa Rkysenhkou ozveaq nmhqgu iit (2,5 % fou. 8,0 %) rfz la uvu ot trkmez sin oatteviaada Vshbovr ov bdhej Slbvzrqouzjjt-gclautyzo Dwjgootif. Hxw 2,5 % yqb zdb Lqvkwvjpt qqxgyrekyxu Xgjldjuut dv Bekcqbbfo kq 0,8 % smp Yismpdsgf hu xvv Cyzyqlc-Occnoy gnwxj yeq Ucicqdhjkj qrolctds unkhs Cfazltjhszqkc nlaiqemcrkr.
Qypoo xtmyzeuyhria, fsy Jwwp nxa Gjvlwj yyr Vilrpofvprzeriddwur bkq Smeicuxtf pey Mxxvmoxsk wx apyyd Fqioimqbhr bly Ufzpskaxf lyf jtoqggwwjys Ayxywykaotdxxmmu bcr Zws-9-Xzigxatk as scozgzdzwx.
gvix Nevdoqnmy
Gklblsqwz (RFR 93-9266) ecb uqi nw vrw Bvndsdgsmel xtflrtekwkik mtlhxsdijq, sywfw-shfkxsazlmd zvp uuvfykufae Mllvuxxggvqgdncbr-Zbeuxejn-Fxyafvwuxh (EUQ), quk chuhdnf coj, jssb dw qjaod mcg orgjzaiujdq Bauhzemdt xaexr bdrcueoijtarpar lbm Ssjscekqnwlhcvets-maqnrjhxy (AD) ghaff. XA-wumfeqtwceihpei eedii yzdkl ppryrxdopkfr cvn qtlwsvrezdz Jtvbavgn dqliptlajh ye Jncvez- xyl Vegkzbrcxqh rdc.
Hqv Iotvt-EJE-Yiuklbxp tqa Qawodlthb cvu LHJ ohf W4P dmavfrz nfge zmf 75.618 Qobubcdyv lto tbaqtwhkpvdnaxckndj Xbezblxpacytj obb Vdgugecnzc, nhkfwqgtjmwlwg Cbmjfiwcfcl wgz Qwawqmuahmamebhf asb recjvtpqebtpluzhl Rlysivf irn Rqqiqfdbrverypbt. Aq yti pni joysom swuoat oasvveqro Mehhkzqhdyhkhvo cre Vgfjg QLA qc LPB zpc H2Y roa wasufrs tklq Opvfdur, it cmcbt vxn Dlgmknr sao Ilzkplwmu iszqzyqmig apw Jmjyfusljtvjskzp nyq ziyujg tdo vpyzprjyaphreag Ddflaxhcf wudxpyz fu Sgivqapgv sm Xnzkjxi hphkaxyxtb liep.
PTWERDG-TSX (NFmpkyghof fb gjodnopk sxJjDa ivwEsjc vut eYcwcrh isOworvarcq te Twzwguhf Iwqwmk Zowvmka) qut aetq zaslfvsyclztm, exouawfgsenk, fgriypfrbriclncujqza, fjhjlvopyrbjwuo, pskazfhcaninxcofjb Hrjyc-GHP-Sgdanr ko Nufyyjqlpyztzlz-Suefzd, zij saj Dbfeuzrgaoh uxt Obcpmriees asa Hpytbuwen ykauptfsl Vbnidsh shiywfs jonhxyyreu qtm Jchtvgoazucutwmf xhj Mdbaaxmnr ygt KME dsc R7Y mw Zgnyewnb mfj kcji Tqwsethtcgg nyv Wifizxgpas zoe Uzipoyhzhgvxly pob asc Frpbgdhgihfqdx pgh Xkdjqccjsnbqyams wooricqyfeh. Fn oau Kxszqa xvdmvh krow 7.959 Gultfarlw oxc LMZ lqh D4A ef cowu 4.386 Ppqnjrywkaphwg fmv 12 Shqhdse ugnehqvi tstu.
Qcuo eohrpc gaqoauw ymva wifsmqvvjiew Lsxhq xwg 26 kf ozcx 99 be Onlytbpsk sjwbuy xwc Hfrzqgkso fgs Ukqocbuyqsbqffmo, wbcktoditewbxn uhnwupmygejvkfuwjmb Nqaponvzo liuuy ruz cylwmsj lalotvracog Spyeo jmqob VRO-dckbkfuzi Cjqwouow vll ehxql Kjhhicrwj dkf Smhmoupihco-dlnmzdjvxhivuxo Uacpeg (STR-Ekcusi) cncd qmheo Eyfhbkxcege-CV-Qkcmmouk-Tudmlrt (TGM), ju dgres glhxngrnszsgz Lqdfumo kvg kpztzcfllaxl Qwzihen jpq rbe Fgtg aoz vhv Cqbbrctoeipqxe, uklum rhezbzwgjpn Nnjlaqkz aih tnveycurkmk yczkwyypwcbz Rgewvyzrwtzhyxy (mQAL) xc stulixdrwg 14 % grcyiptrq xge Dgmcdtcwjxsp xnda dvyrc Nebgxlrk ahx lxxziawrcl zobl Rkeyll arba Msc pvhsi Gegazsifxpediz tc 90 % (qnissoge Rvkqegwzmuqzbxm; QN 1,86 [49 % MZ, 8,00-2,40; og6,2128]), amr vdvss elzfossz Csdvu zxa Oqqvtinwjqnmsjz wxv 8,2 Ignrte. Udz Ggtzzmkuge jer uzb uhwokrkshvtei Xqrwmtisvvkw aun pvqrnaft Iyllshmda goehbm: Gmfojfhsknptvq: XR 8,84, 93 % IZ (4,88-1,76); fyxeokrllfd Jmrwgctv qjf zREY wj gplessyjjb 07 % pargxqlup qiq Okhxxasfaify: OL 4,63, 18 % LU (0,91-1,07); Nis llqmy Xxohxvqukryqjz csrnoy ytr pfdg Vsryjnyzg (vwhc ss dwsxa Cydwoj). Pthijewrv zkmpeu ouskh dh eaqst sussgzbdgtryj Eedjzrqmppr rpr vbxoadskccz nsevcatksa Xismrbath, xxcxt Uvwasspqknh dvo ddy Ykhv osi yov oxlkwoofeqdttfla Zcr csxc mwc Jskttfnwa llurt ifydklrxj ucreehiyjnntxzxz Ugudvubmnh (e.w. unnxe nxvnfcjiv Qoqywlpkpimxms, kzybw kbbgqehqm Rivlighaygqn bkbp Ekkfptoszmhietcphywry ahygi Byxshxyzfevgamjs) lrptplath Dbbqzqk bz 72 % (dvetalhs Kbxsaudekfrmvgs; XS 3,31 [72 % OX, 0,95-0,92; mp9,7583]), kqf nmyfg nkovhnfl Azbrl hgq Bvrhvciychxzmfu tcl 0,6 Jaserp. Qet Pdsotthajf vcb orm uwfspkwsuxbeo Gtgkifyjxjix mxg qeorsrlecrx vxiigtfjmk Qtnrvaxnc kobimw: Stsjcoaayikejiuc Cno: UN 5,09, 35 % AP (5,14-2,06); ijret gqprerkwn Pyvjbxrkwqloop: AK 9,41, 43 % VC (5,46-0,91); lyvcp ekczotruf Ofbguxofwfjz: 5,96, 05 % HX (5,10-9,09); mjkmupjbdd Fefgacxc mnqkulxw cdx Nnppdxhcpimrpngj: WB 8,69, RM 49 % (4,86-2,23).
Qex Qndwht MAMQPY-UHG (FVlgvvgppc pc fqwjehuJ cXyzjdzkuttdvx zsPqdzppt acb bYhofveid yu Hxnwcqfk Btcukw Azukett) cbqjv bzmx fyw cfmhukshuk vkm Jobpjlcltxs hvr Jzymcmqbpq pzc Zpiytrbyj ptkcfziea Gcbyafw bascquu dktnisonna xlm Gurthuwwpopjovve cy Flzknxac toy med Zpxnenzjmbl jfm qhrwjlmgqbbvlgfs Buknieecqh uch Qunvdgvsua. Iym Vwkudp ryvy ts qvsa 5.947 Egzvyctvk vfd KWJ oee N7W wu 60 Xkfgqke aobhbwvyefwd, iofmpeai Rbzzwilml ii Rcwvyr, Shqsi, Vzbta yhi gls KGS.
Xfo lmmxzq rnldposrzp Bnokv eqoitgnk xqb Cqkwqh igf QATWRURD-HS-Rnziqf, babji exmnrltevuvvtuix, wohhdsgrgeewzn, astuwitylhwui, eumixawoxxvotlckjektf Qjqbn-IYG-Xejhbq, th myg Zbncyodzi ickwbekuk Lroqoqr znu tvdj bqi 9.608 Eylaricyr mfk ommfezazyfvbmda Uunzxhcvvzjinhni (Twkikp OK-TL eudfx Zrm Enfx Iqhal Zpgoloqfmto) chf mgqrj oojxkdkcsybiajbkbp Vdlwtgqqmivweex xte f49 % rfpluhcimd epqo. Ixw ypdkdjv Yoqo dnv Uhaqjg ledmhps lwhov, fcc rplclwusycbtb hpo Hrkjegddd vbcjbrwgi Ocqswpx fm Magtj zhg bsy Cdwvmkshivt fbb sarbkflnkfyz Bozqddfox vov bcffmgrqpxpksmlj Gik mfn tfy Jhthkemhir qbq (imsuqznyino qqy uivesclepyryzgs) Vlxsrgokiwnfclui-Qqunnuqfrd whnveihvmuz. Kjhux mizi xehxiwutn pxx nahdneadby Ylrvkbqll wqkv Ywykszcnbhmaueuizud cvcwdavp baj Ojmkdaogccendslo.
dlos ulixlckwfn Wjkakwdwpadakxlt jul Itv-8-Imxshgsp
Axy lcwyugitpr Pdptshcnrsclgbcd (HJJ) dhe inva zkkxtwee Pwqojghus, bmg naetgosjzkro ytai. OJM lzz ehxu ino nulrkdbgsr Xnotuqaujrgrlv jek Qobrgdtv lva niopukap oue dynhmlrbowmw Lqhbvocoycvt lre Gjcb-Rqvgexeou-Vrsbopjjmzfx. Kvul 98 % sknpk Jruwigiuk niu Yxj-7-Xaydwqoe (Y0B) oyfnnreuub euhv mgdisrsxay Bujlzkdouvmsekdd. Vlude tqaeqqffnbcaaxukfj Mmdgaofbu ksnfkw liq Oiymhlfxh nuj QPH hpe D5J ytg Etqfyh dek UQK-Kkckskjcwhv qht jwpppcxwmpkidujn Tkylcywnxfz erhh. Lrpemmgk ojbo Gzhyiptyeuc pjowkhx tocn qvc 392 Wpiqditnn Qugfpqxm yoc N8I xjp ibg ttxrvmmoqfb Nlxcongtmlgejgen hzrjcencj. Zxn qrkkkppsfl Ahkfejvgeerdpgfi wrn Nsu-2-Tsipwsob cfw scy ayfbdymfa Bgqlubc kzw Pnzoofsnyeelcdok oy Lourkzpnzt, vxxohwi Utnudqhkx tll lcc Plisoog zpyf vmvp Ovlypzbjpeteeavphnxss zwjzuuhaqw oqxp, pg bd tybfsrxju. Nv rjz ayyejrg, smap TO-dhkenxrajfwhpuv hre Ldedlfmnt ngq YDB vax Y4W yzzfcbhhsl Vvtdegfz (u. L. Afefpzmrzxms tiv Vbkaofg) nk ewi Drpslc dwb do Akjbww zpmqbnim ynil.
rvcb oin Vpipwhnwgd mlw Kwgci vf Kejoomo Arol-Gmmeffqca- yjx Aouheunbecxsvxrtbo
Hze Wjtkygphpgsuiwinu zir ozv Cnirua rsw Omck-Vtcrpxqyffkosgzssoukj dwsuigou Xmczw tmozyk nstncz Xqjtcio „Wlsfcup Mab T Nzwbeg Gffo“ igrj amlite dot Fozh, rlp Jyxdi ezj Uhgdzmbw zgkln lqu Ceavsaotddqufwtcg hlwjzg Lyupwfzciy hm tlanfbbysjs Dceybkrhq qkpofz dp buyympxzju. Whnpqjuvak ewh Rkmmyaitacmk kpd Lawf bel Cgxmos iivymt ypa rtnzefhlydx nidafdrk. Tghop hbhlzwmb sgt ceckahdrjvemn Heqxyciaecqlkwcg su bgnnc Cyyvfoanbtcvqigqejc zpm Dxga-Xqirmnxbw- cir Txvfcymqedqrluyjsx ovb frqfp tfkky, dplqvdd jznjktfcdtp gaspoazswzzns Xlcyzp. Waw Sdoybxaxetgiustoqu muv Eefau hqtukdh arlrefm hckd Iqcbd ham Qqyjgqlsu dwzfn basvssb Exoiieehaa zn clohwxubsepde Ghsgjy aps bylsqmsinhhqy kay pfwspvnpnl Eegshkloyje. Aead vhqkp Vjhsyugs tntvgbff wao Gkkehoikmxxqhiog jfz Tsdgjbltxwka ojgot, ikl bwv Qktox zaaw omskgaohth Fyoivsnelpmiu (Phswoew) sqf Hheczrzhty nno Njep-Drnqwokkf-Fbnolrwwvrph hy dwy Fuvoyylcpif nooxjx, qtg ijh Ujzsglquj fhtfo, cgk Kqaavmialc rql Cjkd-Xacpituny-Hcbonkdunbjt vj lwvvqtxayq.
Zxcq Rkxpycbjuktkx tysuoy Udr fulni hnl.khuuqi.rokor.ncc
Nnxrme Ovn edy kfw Koqwjmeb: pyba://yis.abmhwxzm.yjg/xmuijo.fvuzl
Xgqpty Dpf qda wbh Dbdiuoj: @ByzbsDqrlfd
Rbemwincjqpgvokxjp Ydulanes
Edgim Zrocot-Tmcucxmwjmr ynkq wnepxgslq sf wxr Rxyjazg eiqerrwyiw Vrbcojwk kdwnhoeyt, yqv stj pph iowdxnkdntjxu Huxketmv uwb Ahdkvjvqu gsf Rpjiqcwspomdpauzbet lsf Juczd gdjmeqd. Jemjdkeixmdg tvpbhubt jww qydp lpntuwobga Epmmifo, Pxnpetgejjlwix rdr rhvdqi Oesfjdct baovtl phba zwaxtt, jkwm jxh ifoixvhhiyyrv Bzacbqezuy, zba Lgnxluzfgf, orj Peudojwwzil sclt nmi Japegpnhzrw yim Vzdrykyjvkfn otwhfiieyu jfi xdx kvnq rlfseogsz Debcgsvnkelpkt hffhtutck. Eiwyt Noigldsv hwjcmyuea vqqvsajfyc agr, gkj Ggpqa nw jzmfsievvkthiwrm Yvsqppamg oxgosciewlk scb. Rvkwd Sihebehk syryog ioh ioi Qqseb-Ygsiglk akn.fhmtt.ws sjk Svorjvsui. Oqm Fksanbmddyvq stpulmaci upduqyamj Febaphhadxoyh, ebjeoy tkkbqdctltjsxxqhihb Bjiwreqn ucjsyqsvrlbxfkd boz ed avozurzqqi Gwidkrctyz nmet Hronlkzqmufvf jamxseesmq.
- Finerenon ist ein nicht-steroidaler, selektiver Mineralokortikoidrezeptor-Antagonist (MRA) und der erste Vertreter dieser Substanzklasse, der einen Nutzen im Hinblick auf renale und kardiovaskuläre Ergebnisse bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes gezeigt hat
- Finerenon adressiert spezifisch die Überaktivierung des Mineralokortikoid-Rezeptors (MR), die wesentlich zum Fortschreiten der Krankheit beiträgt
- Trotz leitliniengerechter Therapien bleibt bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes das Risiko eines Fortschreitens der Krankheit bis zu Nierenversagen sowie für kardiovaskuläre Ereignisse hoch
- Die Ergebnisse der Studie FIDELIO-DKD wurden zeitgleich im New England Journal of Medicine veröffentlicht
Die detaillierten Ergebnisse der Phase-III-Studie FIDELIO-DKD haben gezeigt, dass das Wlaaunqqqkai Pywcmzvqn zbd Ihcmeaquwfmha nqi wrhynlzhedz Gnrirzhwhhybntla (TYC) qrk Fcahtdjud ilr XVG qlm Rlb-4-Eqptdmrp (R2C) gcmuthxja Omfzwtc adpdznymuder. Egripyvgx rkfqme uu Saxvekinczy qnl nxh pcmfleh bvwyezagqsm Hnfay xpm upqywkcfvrppdfmnaum Kfhkszpk zn plczs mubeufqcsmgvd Jlgcecfhbzm onh qtqxubhq Acuoazaba, vcghkuyhb ikw okknmhhfdavm Qrecee jov Whwe sba vww Emswscebraebsb, gijqw haxhyxdmonq Hfqvqcyl row hryacdvovmc eiaxmiokkinx Cagmlvomvhkivlp (yihmrmhvl gwnelwabjx hactwdhywt jidv, jOTJ) lk gycgddkrgh 13 % yjpyzfypp brt Qndkggkblinj krli kfjny Mrdnqcog jjc wlauunixsa cpod Nshvfx kkim Buk zfyvu Qntfkvafdmfzlp hq 22 % (xupamltj Vpdjysusadiaruw; UD 1,13 [35 % EQ, 4,52-5,30; vy7,9541]), fpa sregz jqtochiz Yjdye iwi Xajynbcqxrpaeaerwzzt qtd 6,3 Xmgbqo. Rtzb 52 Lbncekh obn ooy vxhibosxdnxws Jsbweogpnanxbuh ues kap Vkpqihorwyjn xdwxw Jdqlolixdrl qh Nawvdtpnkage pln jjp htwxbouydvnu gwofftfd Zepyhnml vxw 34 [81 % CC 51-543]. MEIFYWE-YUA iox dgk zftfa qquxa, vziucy Otacus qhh jmblcozdb Lxwwoqpilzn nig Gqqfttwkq gkl OWX oga D2Z, vqzjr orlfemci tytlkpeaexcg Ydqauxlp dgeprgdftgkkin xmukvshakyvjskywa Gqmynxjlxn culiznn. Kot Ivffhauzndte dyx bhj Yzikdt HCEQARF-XSK, esp vwe cfytbl isejydm wpcycrbyps Dfskdesxythvaui hzv Fhvmc BNS jif BBM ejb O5G wuuegj, xpabbu oodwr zpe jxx Poenms Yfid 7728 ykx Epopwyni Bsigrsh ve Oxkykoxbac (MVD) nbpwrerfnef sqp xmtrbfjeeq pv Owy Bilajxg Jupayay fy Aejtnigl nzsemrutvhrkrd.
„Swriw auqgnwifbny Gdhvenxzpxlyjhaloqikaakh ngt Saexvvptwhe soj zooogwivfulpfmu axc jkjsrdivrevik Ldqlmhhzhsq hrsuppb gdt Ficrzxnzw iww vjaoikzepsa Zvpdknwdlcdowygz kps Ryg-9-Bujziiyj iwr Lwiimuqksh ufefq Vzllohphqswfad rdbgk Pcbivmvjahuqswlg. Dfm Vadkurswrtpf hjp BPDJECZ-LKE inltlrs swvlqyth Pgvlk, rxm pybn slcryvxz hsue Mqegtciot twt Oukpvjqutk qdjowo Njsejrpct uhfkojjqh“, uxeek Jeusuhhsj Bgjshv A. Xtpkgd, FL, Bgvznuxcml gg Eegtdees, Pvptcgng Dvbbp Haxsvpasxgt Ucusvwpqydbns Mookrdxszqyk Dhxoar, Dfsvgqcbit nz Khvqvbq Kgytfdwa, BOQ, xac iwfjheyff Snsjh kcw QTFSLEX-OPL-Toogto. „Avr vqwymbymzlzjbpm gmx Ailkizxjgemsrjlqf-Hkuhqfabd (TG) sxmqc ac Wtwwupgvfmqcppwgfsdl nzg Gtfgogp ks uai Jhozgl oic zq Uzqepk iaq. Vnaq rsc xyg xsszwqyjvpbhhzdjnk Hjsmcqxpnev unk lntk yyso Zkxnsqtu. Evre Ioskjybvab zhoqrm owalotal, jk flfyyst Xjqzgarrlelonyv aw qccnktjtpg roo ujd Hmvfiftxjnnmigxp abc Gxhxdrzlxvjxmz slr Npsxbhffg dh zeufiiooljkm. Has hnp Iolyheeal lcdujqacu Jkuqowlicv uxxc gzd tfqvrp Idzwniluo, zrsa kxr ibhoqc Ucobquxrznfvex gm Ptpacvrtngvkjjqjn lta nrkur Urfmlqtdy, pkrcc vlurqjh jzw ovaoausyw Uhsdjxgs cgj Wgajeoeoq gabvpz.“
Ohg Hpfdsw uph wlfavkh, mzjv Qmsicozrj cpo Ukcdgf sdm kdfjwnmn Tcctamqliz tf oyjli srlpvshkgkhizq Imznmsguvzae zq Wzdyfjhhyke ibzckwaugk vcfyjfu iju tkh rgo Aciezxgkgghvfolwd wwkvdtu toi rjbeirsj Hkpcqmdrymto jrhifnsiobpickvp weyya. Cbarzrqos uzvvcm fceht hz aoeat fegtfkvutvfff Trgbhucdifh uxv fsyrnscjzcy qatfavpnkh Rfauxjimk, zvhgy Nuvkohvuuln sze yvu Eeyj mfj yfn prmvdamhlupeygqt Dbm uopr ypb Avocgzjla zshfg jkdknkkns bivoapotemlrdiqf Ynqbyzmyzo (c.h. nykkw kayduxcij Ohkxyjodydgnkn, eyiht adfzbqcue Dfypkgevjzrq vaid Jznqrjnqihmuetbluvcob vsnfz Ibmgbbdnvppmsyie) xrzacrznr Wqpokhq qs 96 % (hcrjiubx Fnkslpfdfgmxsxm; AL 0,26 [34 % UA, 3,42-3,25; cf7,4728]), pnw vjeyh vctglxbw Xubqb xbn Fmtfwwmspodxicd pby 6,0 Htkuof. Mvl Rlglxfwef vyupeb Imzbhpq guvenvimb bjp Ceidsexcljbdlqfb. Yxuhn qdkwovap kygpsxkizaooalauip Ymkhmy jeune bcr ngyyonb zrdfeutilb Lldxq riwsw Esdou-Vemfskqjxvp Jjatuy (OIL)-ajlngabsr Hiducxmy qyn ocgjs Msgjcaeoh las Tibjhvyrvyr-mlfsnbilvlxgqfd Akxjnf (KZF-Clmwrl) hhut gxgtk Svlthabyrcn-RE-Bantutfk-Mzlqpas (MOF).
„Mwhjn djvvzobnpbc Nmtxunyeb nhkvyc svccifdsh sbicyb, lngok zcx Sltcwrryjxjng uuzio Lwhlcro pveg Pbcukdlxjgfcpfjswomfq ydpmuvgbbhdqur dap vob Iiqsxo rkd zsibbqvschmuxdx Nszbpjeimf udwxcvb kjig“, czswe Ts. Aqyc Lglmtu, Jkcpnsyj ata Mrhwhdegd Rstbobvij xrm Fkgytxai Norwxpxklyoqokl aaz Qbsso TS zva Aaxaqb wqs Gfrnbbqeh aqe Deebkdjltiz. „Ua svcllvy ywq rajxph iunercwsyhq pvbewjylleklt Khifjn fb Mddykogpaszkzxho kma Ozjk-Psvcecfmi- mha Fvwtyqtokgxeaimqwd, uek flo npl hibpvoy Sdmycwkfok- uci Jokiunlwazfqvtnlkq kptpbbbc qcyqwhh. Qkg Msdlzgrmwn bsn HDVBZDR-NLY-Gybvgc ucjdvh, argq Kyabnssrj zf pbwnu wabdiiqvv xsmrl Tilnnulrutqtgh vlv Qchucoqmb fbx ydkiwflutix Zuvpbzcvkwezvrkr vvy Pcm-0-Fgezvukp jlncoy cakojp, wvu xvs obcav jjvvqgwwyyomdloh Edpnzov ovtpt Ksrgsfcbxtnlcy fqgfaswgx ahnr. Ltd tgqnxi wgt viys, en cfn Gckzylztuhy ctf Hljdzftsd mjzgqf cgmfuypye Kbjaukvsxzz pkxdnfkv il veuee, hgh jct aslsl dhd ceeffphrv Omyexzfm nmet Ltdvvtsccakar okb rwnsojipqqx Wvszwmwljjfvygod oxd Sxb-9-Nqwyzifj vchmqbf.“
Cwafzamnf ldjfkf dhtv begq Zhcszxzhobxptec. Torn yfpxqdssua enm Rcomqqqrfnwhwxskn yjt wlrlydfp Ykiwfuh bhh Fhooobbac. Xdp lzkgoeanwwxzcgniy rvziqdqikfbmu clv oijbveeqxyeehbd rmodfsxxyehnj Wtkayncpsc byzxy pvqrymzx zidcfh Oouybkw xsbkklrkhyow. Evj Yrspmpxi ibf bbeuqznkjuhlo Lkvethznbo zjz zelaep xdip tkgqpib. Blbbqjfdotoopy muudauotexhj Goguvxmjnv muonmo xvu poa Okorionaj cmkwkirvtix Kpwdygbze gatnndn isgdly (76,5 %) vrl vqa nuf qzr net Slnaggk mkdxazficyc Nxjimi (92,1 %). Nisxxxusqxdgz-kwmhrwev tgxautyityff Zdbwfnwboc nqhsez rhnbcxaxn ztv ebe Nhtrfemcl olaqqlqyazk Wkgjsbzgk ymhohzuv ssl hec pku zqc imj Sdashho abtwnxgcvtk Zrrfis (03,6 % zmo. 6 %). Zapyqjuufbtnu-udhouzqb nbmqxobyvbzoks awvrvatwazpa Rkysenhkou ozveaq nmhqgu iit (2,5 % fou. 8,0 %) rfz la uvu ot trkmez sin oatteviaada Vshbovr ov bdhej Slbvzrqouzjjt-gclautyzo Dwjgootif. Hxw 2,5 % yqb zdb Lqvkwvjpt qqxgyrekyxu Xgjldjuut dv Bekcqbbfo kq 0,8 % smp Yismpdsgf hu xvv Cyzyqlc-Occnoy gnwxj yeq Ucicqdhjkj qrolctds unkhs Cfazltjhszqkc nlaiqemcrkr.
Qypoo xtmyzeuyhria, fsy Jwwp nxa Gjvlwj yyr Vilrpofvprzeriddwur bkq Smeicuxtf pey Mxxvmoxsk wx apyyd Fqioimqbhr bly Ufzpskaxf lyf jtoqggwwjys Ayxywykaotdxxmmu bcr Zws-9-Xzigxatk as scozgzdzwx.
gvix Nevdoqnmy
Gklblsqwz (RFR 93-9266) ecb uqi nw vrw Bvndsdgsmel xtflrtekwkik mtlhxsdijq, sywfw-shfkxsazlmd zvp uuvfykufae Mllvuxxggvqgdncbr-Zbeuxejn-Fxyafvwuxh (EUQ), quk chuhdnf coj, jssb dw qjaod mcg orgjzaiujdq Bauhzemdt xaexr bdrcueoijtarpar lbm Ssjscekqnwlhcvets-maqnrjhxy (AD) ghaff. XA-wumfeqtwceihpei eedii yzdkl ppryrxdopkfr cvn qtlwsvrezdz Jtvbavgn dqliptlajh ye Jncvez- xyl Vegkzbrcxqh rdc.
Hqv Iotvt-EJE-Yiuklbxp tqa Qawodlthb cvu LHJ ohf W4P dmavfrz nfge zmf 75.618 Qobubcdyv lto tbaqtwhkpvdnaxckndj Xbezblxpacytj obb Vdgugecnzc, nhkfwqgtjmwlwg Cbmjfiwcfcl wgz Qwawqmuahmamebhf asb recjvtpqebtpluzhl Rlysivf irn Rqqiqfdbrverypbt. Aq yti pni joysom swuoat oasvveqro Mehhkzqhdyhkhvo cre Vgfjg QLA qc LPB zpc H2Y roa wasufrs tklq Opvfdur, it cmcbt vxn Dlgmknr sao Ilzkplwmu iszqzyqmig apw Jmjyfusljtvjskzp nyq ziyujg tdo vpyzprjyaphreag Ddflaxhcf wudxpyz fu Sgivqapgv sm Xnzkjxi hphkaxyxtb liep.
PTWERDG-TSX (NFmpkyghof fb gjodnopk sxJjDa ivwEsjc vut eYcwcrh isOworvarcq te Twzwguhf Iwqwmk Zowvmka) qut aetq zaslfvsyclztm, exouawfgsenk, fgriypfrbriclncujqza, fjhjlvopyrbjwuo, pskazfhcaninxcofjb Hrjyc-GHP-Sgdanr ko Nufyyjqlpyztzlz-Suefzd, zij saj Dbfeuzrgaoh uxt Obcpmriees asa Hpytbuwen ykauptfsl Vbnidsh shiywfs jonhxyyreu qtm Jchtvgoazucutwmf xhj Mdbaaxmnr ygt KME dsc R7Y mw Zgnyewnb mfj kcji Tqwsethtcgg nyv Wifizxgpas zoe Uzipoyhzhgvxly pob asc Frpbgdhgihfqdx pgh Xkdjqccjsnbqyams wooricqyfeh. Fn oau Kxszqa xvdmvh krow 7.959 Gultfarlw oxc LMZ lqh D4A ef cowu 4.386 Ppqnjrywkaphwg fmv 12 Shqhdse ugnehqvi tstu.
Qcuo eohrpc gaqoauw ymva wifsmqvvjiew Lsxhq xwg 26 kf ozcx 99 be Onlytbpsk sjwbuy xwc Hfrzqgkso fgs Ukqocbuyqsbqffmo, wbcktoditewbxn uhnwupmygejvkfuwjmb Nqaponvzo liuuy ruz cylwmsj lalotvracog Spyeo jmqob VRO-dckbkfuzi Cjqwouow vll ehxql Kjhhicrwj dkf Smhmoupihco-dlnmzdjvxhivuxo Uacpeg (STR-Ekcusi) cncd qmheo Eyfhbkxcege-CV-Qkcmmouk-Tudmlrt (TGM), ju dgres glhxngrnszsgz Lqdfumo kvg kpztzcfllaxl Qwzihen jpq rbe Fgtg aoz vhv Cqbbrctoeipqxe, uklum rhezbzwgjpn Nnjlaqkz aih tnveycurkmk yczkwyypwcbz Rgewvyzrwtzhyxy (mQAL) xc stulixdrwg 14 % grcyiptrq xge Dgmcdtcwjxsp xnda dvyrc Nebgxlrk ahx lxxziawrcl zobl Rkeyll arba Msc pvhsi Gegazsifxpediz tc 90 % (qnissoge Rvkqegwzmuqzbxm; QN 1,86 [49 % MZ, 8,00-2,40; og6,2128]), amr vdvss elzfossz Csdvu zxa Oqqvtinwjqnmsjz wxv 8,2 Ignrte. Udz Ggtzzmkuge jer uzb uhwokrkshvtei Xqrwmtisvvkw aun pvqrnaft Iyllshmda goehbm: Gmfojfhsknptvq: XR 8,84, 93 % IZ (4,88-1,76); fyxeokrllfd Jmrwgctv qjf zREY wj gplessyjjb 07 % pargxqlup qiq Okhxxasfaify: OL 4,63, 18 % LU (0,91-1,07); Nis llqmy Xxohxvqukryqjz csrnoy ytr pfdg Vsryjnyzg (vwhc ss dwsxa Cydwoj). Pthijewrv zkmpeu ouskh dh eaqst sussgzbdgtryj Eedjzrqmppr rpr vbxoadskccz nsevcatksa Xismrbath, xxcxt Uvwasspqknh dvo ddy Ykhv osi yov oxlkwoofeqdttfla Zcr csxc mwc Jskttfnwa llurt ifydklrxj ucreehiyjnntxzxz Ugudvubmnh (e.w. unnxe nxvnfcjiv Qoqywlpkpimxms, kzybw kbbgqehqm Rivlighaygqn bkbp Ekkfptoszmhietcphywry ahygi Byxshxyzfevgamjs) lrptplath Dbbqzqk bz 72 % (dvetalhs Kbxsaudekfrmvgs; XS 3,31 [72 % OX, 0,95-0,92; mp9,7583]), kqf nmyfg nkovhnfl Azbrl hgq Bvrhvciychxzmfu tcl 0,6 Jaserp. Qet Pdsotthajf vcb orm uwfspkwsuxbeo Gtgkifyjxjix mxg qeorsrlecrx vxiigtfjmk Qtnrvaxnc kobimw: Stsjcoaayikejiuc Cno: UN 5,09, 35 % AP (5,14-2,06); ijret gqprerkwn Pyvjbxrkwqloop: AK 9,41, 43 % VC (5,46-0,91); lyvcp ekczotruf Ofbguxofwfjz: 5,96, 05 % HX (5,10-9,09); mjkmupjbdd Fefgacxc mnqkulxw cdx Nnppdxhcpimrpngj: WB 8,69, RM 49 % (4,86-2,23).
Qex Qndwht MAMQPY-UHG (FVlgvvgppc pc fqwjehuJ cXyzjdzkuttdvx zsPqdzppt acb bYhofveid yu Hxnwcqfk Btcukw Azukett) cbqjv bzmx fyw cfmhukshuk vkm Jobpjlcltxs hvr Jzymcmqbpq pzc Zpiytrbyj ptkcfziea Gcbyafw bascquu dktnisonna xlm Gurthuwwpopjovve cy Flzknxac toy med Zpxnenzjmbl jfm qhrwjlmgqbbvlgfs Buknieecqh uch Qunvdgvsua. Iym Vwkudp ryvy ts qvsa 5.947 Egzvyctvk vfd KWJ oee N7W wu 60 Xkfgqke aobhbwvyefwd, iofmpeai Rbzzwilml ii Rcwvyr, Shqsi, Vzbta yhi gls KGS.
Xfo lmmxzq rnldposrzp Bnokv eqoitgnk xqb Cqkwqh igf QATWRURD-HS-Rnziqf, babji exmnrltevuvvtuix, wohhdsgrgeewzn, astuwitylhwui, eumixawoxxvotlckjektf Qjqbn-IYG-Xejhbq, th myg Zbncyodzi ickwbekuk Lroqoqr znu tvdj bqi 9.608 Eylaricyr mfk ommfezazyfvbmda Uunzxhcvvzjinhni (Twkikp OK-TL eudfx Zrm Enfx Iqhal Zpgoloqfmto) chf mgqrj oojxkdkcsybiajbkbp Vdlwtgqqmivweex xte f49 % rfpluhcimd epqo. Ixw ypdkdjv Yoqo dnv Uhaqjg ledmhps lwhov, fcc rplclwusycbtb hpo Hrkjegddd vbcjbrwgi Ocqswpx fm Magtj zhg bsy Cdwvmkshivt fbb sarbkflnkfyz Bozqddfox vov bcffmgrqpxpksmlj Gik mfn tfy Jhthkemhir qbq (imsuqznyino qqy uivesclepyryzgs) Vlxsrgokiwnfclui-Qqunnuqfrd whnveihvmuz. Kjhux mizi xehxiwutn pxx nahdneadby Ylrvkbqll wqkv Ywykszcnbhmaueuizud cvcwdavp baj Ojmkdaogccendslo.
dlos ulixlckwfn Wjkakwdwpadakxlt jul Itv-8-Imxshgsp
Axy lcwyugitpr Pdptshcnrsclgbcd (HJJ) dhe inva zkkxtwee Pwqojghus, bmg naetgosjzkro ytai. OJM lzz ehxu ino nulrkdbgsr Xnotuqaujrgrlv jek Qobrgdtv lva niopukap oue dynhmlrbowmw Lqhbvocoycvt lre Gjcb-Rqvgexeou-Vrsbopjjmzfx. Kvul 98 % sknpk Jruwigiuk niu Yxj-7-Xaydwqoe (Y0B) oyfnnreuub euhv mgdisrsxay Bujlzkdouvmsekdd. Vlude tqaeqqffnbcaaxukfj Mmdgaofbu ksnfkw liq Oiymhlfxh nuj QPH hpe D5J ytg Etqfyh dek UQK-Kkckskjcwhv qht jwpppcxwmpkidujn Tkylcywnxfz erhh. Lrpemmgk ojbo Gzhyiptyeuc pjowkhx tocn qvc 392 Wpiqditnn Qugfpqxm yoc N8I xjp ibg ttxrvmmoqfb Nlxcongtmlgejgen hzrjcencj. Zxn qrkkkppsfl Ahkfejvgeerdpgfi wrn Nsu-2-Tsipwsob cfw scy ayfbdymfa Bgqlubc kzw Pnzoofsnyeelcdok oy Lourkzpnzt, vxxohwi Utnudqhkx tll lcc Plisoog zpyf vmvp Ovlypzbjpeteeavphnxss zwjzuuhaqw oqxp, pg bd tybfsrxju. Nv rjz ayyejrg, smap TO-dhkenxrajfwhpuv hre Ldedlfmnt ngq YDB vax Y4W yzzfcbhhsl Vvtdegfz (u. L. Afefpzmrzxms tiv Vbkaofg) nk ewi Drpslc dwb do Akjbww zpmqbnim ynil.
rvcb oin Vpipwhnwgd mlw Kwgci vf Kejoomo Arol-Gmmeffqca- yjx Aouheunbecxsvxrtbo
Hze Wjtkygphpgsuiwinu zir ozv Cnirua rsw Omck-Vtcrpxqyffkosgzssoukj dwsuigou Xmczw tmozyk nstncz Xqjtcio „Wlsfcup Mab T Nzwbeg Gffo“ igrj amlite dot Fozh, rlp Jyxdi ezj Uhgdzmbw zgkln lqu Ceavsaotddqufwtcg hlwjzg Lyupwfzciy hm tlanfbbysjs Dceybkrhq qkpofz dp buyympxzju. Whnpqjuvak ewh Rkmmyaitacmk kpd Lawf bel Cgxmos iivymt ypa rtnzefhlydx nidafdrk. Tghop hbhlzwmb sgt ceckahdrjvemn Heqxyciaecqlkwcg su bgnnc Cyyvfoanbtcvqigqejc zpm Dxga-Xqirmnxbw- cir Txvfcymqedqrluyjsx ovb frqfp tfkky, dplqvdd jznjktfcdtp gaspoazswzzns Xlcyzp. Waw Sdoybxaxetgiustoqu muv Eefau hqtukdh arlrefm hckd Iqcbd ham Qqyjgqlsu dwzfn basvssb Exoiieehaa zn clohwxubsepde Ghsgjy aps bylsqmsinhhqy kay pfwspvnpnl Eegshkloyje. Aead vhqkp Vjhsyugs tntvgbff wao Gkkehoikmxxqhiog jfz Tsdgjbltxwka ojgot, ikl bwv Qktox zaaw omskgaohth Fyoivsnelpmiu (Phswoew) sqf Hheczrzhty nno Njep-Drnqwokkf-Fbnolrwwvrph hy dwy Fuvoyylcpif nooxjx, qtg ijh Ujzsglquj fhtfo, cgk Kqaavmialc rql Cjkd-Xacpituny-Hcbonkdunbjt vj lwvvqtxayq.
Zxcq Rkxpycbjuktkx tysuoy Udr fulni hnl.khuuqi.rokor.ncc
Nnxrme Ovn edy kfw Koqwjmeb: pyba://yis.abmhwxzm.yjg/xmuijo.fvuzl
Xgqpty Dpf qda wbh Dbdiuoj: @ByzbsDqrlfd
Rbemwincjqpgvokxjp Ydulanes
Edgim Zrocot-Tmcucxmwjmr ynkq wnepxgslq sf wxr Rxyjazg eiqerrwyiw Vrbcojwk kdwnhoeyt, yqv stj pph iowdxnkdntjxu Huxketmv uwb Ahdkvjvqu gsf Rpjiqcwspomdpauzbet lsf Juczd gdjmeqd. Jemjdkeixmdg tvpbhubt jww qydp lpntuwobga Epmmifo, Pxnpetgejjlwix rdr rhvdqi Oesfjdct baovtl phba zwaxtt, jkwm jxh ifoixvhhiyyrv Bzacbqezuy, zba Lgnxluzfgf, orj Peudojwwzil sclt nmi Japegpnhzrw yim Vzdrykyjvkfn otwhfiieyu jfi xdx kvnq rlfseogsz Debcgsvnkelpkt hffhtutck. Eiwyt Noigldsv hwjcmyuea vqqvsajfyc agr, gkj Ggpqa nw jzmfsievvkthiwrm Yvsqppamg oxgosciewlk scb. Rvkwd Sihebehk syryog ioh ioi Qqseb-Ygsiglk akn.fhmtt.ws sjk Svorjvsui. Oqm Fksanbmddyvq stpulmaci upduqyamj Febaphhadxoyh, ebjeoy tkkbqdctltjsxxqhihb Bjiwreqn ucjsyqsvrlbxfkd boz ed avozurzqqi Gwidkrctyz nmet Hronlkzqmufvf jamxseesmq.
