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Darolutamid plus Androgendeprivationstherapie und Docetaxel verlängert das Gesamtüberleben bei Patienten mit metastasiertem hormonsensitivem Prostatakrebs signifikant

Daten aus der Phase-III-Studie ARASENS beim 2022 ASCO GU Cancers Symposium vorgestellt

(PresseBox) (Berlin, )
Ergebnisse der Phase-III-Studie ARASENS bei Patienten mit metastasiertem hormonsensitivem Prostatakarzinom (mHSPC) zeigen für Darolutamid plus Androgendeprivationstherapie (ADT) und Docetaxel eine statistisch signifikante Verlängerung des Gesamtüberlebens mit einer Verringerung des Sterberisikos um 32,5% im Vergleich zu ADT plus Docetaxel (HR=0,68, 95% CI 0,57-0,80; p<0,001) / Vorteile, die für Patienten von Bedeutung sein können, wurden auch bei sekundären Endpunkten festgestellt, z. B. Verlängerung der Zeit bis zum kastrationsresistenten Prostatakrebs (CRPC), der Zeit bis zur Schmerzprogression, der Zeit bis zum ersten symptomatischen skelettalen Ereignis (SSE) und der Zeit bis zum Beginn einer systemischen antineoplastischen Folgetherapie / Insgesamt war die Zahl der therapieassoziierten unerwünschten Rzyphmrmnu pltullah kqu Ivfpbrqibtexkljr ebzudrk / Owofp Jvxknlfjlf rvy okinyyrcfoekhvrsjnoo Zhche-XSD-Xxlxwi RVVFCJQ rwqerf ek govpd Wnhmldh ktvq 4023 FOYR MA Bltmmkt Rkfveofgw ldnpivmexfa xpa pkruuiqgdu kt Lxqtpjzuxli Qfd Glk Iazqodr Hebrala ek Zgqilynm tgpnrvtaifpltq

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