The debate on anesthetic effects in the developing brain has been stuck on mixed and often non-human data. FDA/NCTR used neural stem cell models and trusted VITROCELL SC3 Exposure Systems to keep xenon or desflurane, O₂, and CO₂ rock steady during long exposures. When the atmosphere stays steady, the biology speaks.
Neuroprotection revealed: In human neurons, 33% xenon blunted propofol-induced damage and preserved key markers and morphology.
Conditional toxicity pinpointed: In primate neurons, desflurane showed toxicity only in differentiated cells and only after a 24 hour exposure. Shorter exposure and undifferentiated cells were largely unaffected.
These are not just results. They show what becomes visible when your exposure system does not add noise. This is the level of evidence NAMs need to move from promise to practice.
Ready to bring this rigor to your DNT and inhalation programs? Learn how the VITROCELL platform delivers stability and reproducibility for regulatory-grade studies.
Read more here:
https://doi.org/10.3389/ebm.2025.10606
https://doi.org/10.1007/s12035-019-01771-x
Neuroprotection revealed: In human neurons, 33% xenon blunted propofol-induced damage and preserved key markers and morphology.
Conditional toxicity pinpointed: In primate neurons, desflurane showed toxicity only in differentiated cells and only after a 24 hour exposure. Shorter exposure and undifferentiated cells were largely unaffected.
These are not just results. They show what becomes visible when your exposure system does not add noise. This is the level of evidence NAMs need to move from promise to practice.
Ready to bring this rigor to your DNT and inhalation programs? Learn how the VITROCELL platform delivers stability and reproducibility for regulatory-grade studies.
Read more here:
https://doi.org/10.3389/ebm.2025.10606
https://doi.org/10.1007/s12035-019-01771-x
