Explore Application Areas and Exposure Principles for in vitro Inhalation Research
VITROCELL® devices are designed to evaluate the potential health risks of inhalable substances without relying on laboratory animals. These systems expose lung cells at the air-liquid interface, simulating real-world inhalation conditions.
A newly released video presentation highlights key in vitro exposure systems designed for all types of aerosols, including:
Comprehensive Cell Exposure Systems
VITROCELL® offers a variety of advanced cell exposure systems capable of directly exposing respiratory tract cells to gases, particles, and complex mixtures.
Key steps of the exposure process:
VITROCELL® systems are widely used in leading laboratories worldwide, helping reduce the need for animal testing in inhalation research. Their customers include:
VITROCELL® devices are designed to evaluate the potential health risks of inhalable substances without relying on laboratory animals. These systems expose lung cells at the air-liquid interface, simulating real-world inhalation conditions.
A newly released video presentation highlights key in vitro exposure systems designed for all types of aerosols, including:
- Gases, complex mixtures, and particles in continuous flow
- Liquids and suspensions via single droplet sedimentation
- Dry powders in minimal quantities
Comprehensive Cell Exposure Systems
VITROCELL® offers a variety of advanced cell exposure systems capable of directly exposing respiratory tract cells to gases, particles, and complex mixtures.
Key steps of the exposure process:
- Cell Cultivation: Cells are cultured on permeable membrane inserts.
- Exposure Setup: The inserts are placed in exposure systems maintained at 37°C. The basal side of the cells receives nutrients through the membrane, while the apical side remains exposed to airborne substances at the air-liquid interface, closely mimicking human respiratory conditions.
- Exposure Process: Airborne compounds interact directly with the cells without interference from a liquid barrier.
- Post-Exposure Analysis: The membrane inserts are removed, and the cells undergo standard endpoint analyses.
VITROCELL® systems are widely used in leading laboratories worldwide, helping reduce the need for animal testing in inhalation research. Their customers include:
- Research institutes
- Industrial and pharmaceutical laboratories
- Contract research organizations
- Regulatory authorities
