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Universitätsklinikum Hamburg-Eppendorf (UKE) Martinistr. 52 20251 Hamburg, Germany http://www.uke.de
Contact Ms Saskia Lemm +49 40 741056061
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Universitätsklinikum Hamburg-Eppendorf (UKE)

Bisher unbekannter Selbstschutzmechanismus der Nierenfilterzellen entdeckt

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Chronische Nierenerkrankungen betreffen weltweit jeden zehnten Menschen. Ein wesentlicher Treiber ist die Schädigung spezialisierter Filterzellen der Nieren, der Podozyten. Forschende des SFB 1192 des Universitätsklinikums Hamburg-Eppendorf (UKE) haben nun einen bisher unbekannten Selbstschutzmechanismus der Nierenfilterzellen entdeckt. Sie fanden heraus, dass bei der Autoimmunerkrankung Membranöse Nephropathie krankheitsauslösende Autoantikörper die Bildung neuartiger „AutoImmunoglobulin-Getriggerter Extrazellulärer Vesikel“ (AIT-EVs) auslösen. Diese vesikelartigen Strukturen schnüren sich von den (Fuß)fortsätzen der Podozyten ab und gelangen als Abfalltransport in den Urin. „Die gezielte Anreicherung im Urin ermöglicht eine präzise Identifikation krankheitsrelevanter Autoantikörper – selbst bei negativen Serumtests. Damit eröffnet dieser wahrscheinlich hochkonservierte zelluläre Reinigungsmechanismus einen neuen, nicht-invasiven Ansatz
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The publisher indicated in each case (see company info by clicking on image/title or company info in the right-hand column) is solely responsible for the stories above, the event or job offer shown and for the image and audio material displayed. As a rule, the publisher is also the author of the texts and the attached image, audio and information material. The use of information published here is generally free of charge for personal information and editorial processing. Please clarify any copyright issues with the stated publisher before further use. In case of publication, please send a specimen copy to service@pressebox.de.