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Technische Universität München Arcisstr. 19 80333 München, Germany http://www.tum.de
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Technische Universität München

Ein Protein gegen den grauen Star - Aktivierungsmechanismus eines Schutzproteins der Augenlinse aufgeklärt

(PresseBox) (München, )
Die Brechkraft der menschlichen Augenlinse beruht auf einer dicht gepackten Eiweißmischung. Schutzproteine sorgen dafür, dass diese Eiweiße, die nur ein einziges Mal angelegt werden, ein Leben lang nicht verklumpen. Versagt der Schutzmechanismus, trübt sich die Linse - der Patient bekommt grauen Star. Nun konnten Wissenschaftler der Technischen Universität München (TUM) entschlüsseln, wie eines der Schutzproteine aktiviert wird und so die Grundlage zur Entwicklung neuer Therapiemöglichkeiten legen.

Die Augenlinse des Menschen besteht aus einer hochkonzentrierten Proteinlösung, die ihr ihre hohe Brechkraft verleiht. Trotz dieses hohen Eiweißgehalts muss die Linse jedoch klar und lichtdurchlässig bleiben. Aus diesem Grund liegen hier einzigartige Bedingungen
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