New UHPLC unsurpassed in high-speed and high-resolution analysis and productivity / LC-30A Nexera

The cleanest and fastest system ever to date / Versatile tool for a multitude of different applications / New components, best materials and technologies

(PresseBox) ( Duisburg, )
Shimadzu, one of the worldwide leading manufacturers in analytical instrumentation, introduces the Nexera ultra highperformance liquid chromatography (UHPLC) system. The European premiere will take place during Anayltica show in Munich between March 23 and 26, 2010. The LC-30A Nexera delivers highspeed and highresolution analysis without sacrificing basic performance parameters such as excellent precision, nearzero carryover, good linearity, stability and ruggedness. Offering these attributes enables Nexera to provide superior performance in various fields, covering highresolution and highspeed separation, as well as highsensitivity detection.

Shimadzu's Nexera is optimized to enable analysis at pressures up to 130 MPa at 3mL/min. This allows for Fast Chromatography as well as highest resolution using long columns with small particles. Without compromising performance and data quality, the maximized pressure over a wide flow range enables various types of analyses, including micro LC to conventional LC, regular pressure LC to ultra highpressure LC, and isocratic LC to multidimensional LC. The system is also suitable for MS applications.

New components, best materials and technologies

The CBM-20A control unit contains a modified software in order to control the new modules and functionalities, e.g. the autosampler. A new microreactor based mixer, fully developed components, best materials and technologies and new columns are important from the hardware side driving the performance. The users profit from the productivity and efficiency.

High throughput and minimum carryover

Nexera's fast injection - just 10 seconds - enables fast chromatography to shorten cycle time and result in true high throughput with 4,600+ sample capacity. The newly designed injection port and finetipped needle, along with additional features such as threerinse solvent selection and injection port and internal needle rinse, reduce carryover to an absolute minimum.

New autosampler

Regarding carryover and reproducibility, the autosampler SIL-30AC exceeds the performance of the previous product and strengthen its outstanding position in the market. In addition to the wellestablished and precise DIIMS technique (Direct Injection with Isolated Metering System), the autosampler also offers fixedloop injection for ultrafast separation with minimized peak width and gradient delay. An overlapping injection function is standard with Nexera to allow for a maximum reduction in cycle time.

Column oven for hightemperature analysis

For hightemperature LC analysis up to 150 °C, Nexera offers efficient preheating for solvents to enable stable and reliable conditions. The advanced Intelligent Heat Balancer (IHB) minimizes band broadening during hightemperature analysis through the use of independently controlled heat zones within the column compartment, ensuring accurate column temperature regardless of flow rate. The postcolumn cooler can reduce detector noise when equipped for hightemperature analysis.

Most sensitive detection

Additionally to the UV and PDA detectors, the brandnew and worldwide most sensitive and fastest RF-20A/20AXS fluorescence detectors can be applied for Nexera. Furthermore, MS respectively MS/MS detectors are preferred options which combine an increased separation capacity with adequate sensitivity.

"For LC-30A Nexera, Shimadzu's comprehensive experience in HPLC has been strengthened and extended through inspirations and technologies from other product segments," said Dr. Björn-Thoralf Erxleben, Product Manager Shimadzu Europe. "The LC-30A Nexera meets the needs of the most demanding markets such as pharmaceutical and the food industry: Both require the highest data quality since their products concern the human body. The LC-30A Nexera is a versatile tool for a multitude of different applications."

For more information about Nexera UHPLC, visit and/or our new exibition booth on analytica. Hall A1, booth 401/502.
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