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Biochemie: Wenn das Immunsystem Hirnzellen bekämpft

Wenn das eigene Immunsystem Strukturen von Hirnnervenzellen angreift, können die Folgen verheerend sein.

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Wenn das Immunsystem körpereigene Strukturen bekämpft, können die Folgen verheerend sein. Besonders dann, wenn es sich gegen Bestandteile von Gehirnnervenzellen richtet. Forscher unter Federführung des Biochemikers Prof. Dr. Michael Hollmann von der Ruhr-Universität Bochum und der Medizinerin Prof. Dr. Hannelore Ehrenreich am Max-Planck-Institut für Experimentelle Medizin in Göttingen haben nun herausgefunden, dass solche Autoimmunreaktionen gegen einen bestimmten Rezeptor von Nervenzellen des Gehirns komplexer sind als bisher angenommen. Außerdem zeigten sie, dass alleine die Anwesenheit von Antiköpern gegen den Rezeptor im Blut noch nicht krankmachen muss. Die Forscher berichten in der Zeitschrift "Molecular Psychiatry".

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