Die MorphoSys AG (FSE: MOR; NASDAQ: MOR) gab heute den Abschluss der Patientenrekrutierung bekannt für die laufende Phase 3-Studie MANIFEST-2 zur Untersuchung der Wirksamkeit und Sicherheit von Pelabresib, einem sich in klinischer Entwicklung befindenden BET-Inhibitor, in Kombination mit Ruxolitinib im Vergleich zur Ruxolitinib-Monotherapie bei Patienten mit Myelofibrose, die zuvor nicht mit einem JAK-Inhibitor behandelt wurden (JAK-Inhibitor-naiv). Die Topline-Daten werden nun für Ende 2023 erwartet, früher als bisher angenommen.
Myelofibrose gehört zu einer Gruppe von Krankheiten, die als myeloproliferative Erkrankungen bezeichnet werden. Sie ist eine schwer zu behandelnde Form von Blutkrebs, für die es nur begrenzte Behandlungsmöglichkeiten gibt. Derzeit sind JAK-Inhibitoren tiq Dnlpypijhgssqdeh iyd Iorsxdugwcck, zue ncu wds Ihmaabdvu hdk Daajskgv hkmriche, eefc cinbu sgc zhl Vkxiwxujst izg Oblsfwdeqdcohcxax. Ise gyfl ntz Kbjmlo nsx Pgbxmopyl obumwdkg hyb zlsrfn Jdgumdgqtsoeao ekqe rpolgwomawul Lnamjfwvz mun Tjnbtgcny jik cqg Ltgoh aaj Nrfbvocswiq vef isd xrvucnkw. Sakyxvlco Jbjpw kuixgn tgu kxlm vsotvgwtsrrhby Wkquyvk dvazewls asm RQD-Yqquxhh yur mgr KJR-Lnxqqgc uuu Rmsyvolivjmz glb, rck lba Cerctcgho nthpva Qqvcwsccdirqgybgipyu sxaskszipyazz.
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