.
- Kombination aus Pelabresib und Ruxolitinib führte zu einer signifikanten Verkleinerung des Milzvolumens, die SVR35-Ansprechrate war fast doppelt so hoch wie bei Placebo plus Ruxolitinib
- Starker positiver Trend bei der Symptomreduktion und doppelt so viele Patienten erreichten sowohl SVR35 als auch TSS50 im Vergleich zu Placebo und Ruxolitinib
- Verbesserung der Anämie, einschließlich höherer Hämoglobin-Ansprechraten, weniger Patienten mit Transfusionsbedarf und weniger Anämie als Nebenwirkung im Vergleich zu Placebo plus Ruxolitinib
- Verbesserung der Knochenmarkfibrose um mindestens einen Grad bei mehr Patienten als im Vergleich zu Placebo plus Ruxolitinib
- Kombination aus Pelabresib und Ruxolitinib führte zu einer signifikanten Verkleinerung des Milzvolumens, die SVR35-Ansprechrate war fast doppelt so hoch wie bei Placebo plus Ruxolitinib
- Starker positiver Trend bei der Symptomreduktion und doppelt so viele Patienten erreichten sowohl SVR35 als auch TSS50 im Vergleich zu Placebo und Ruxolitinib
- Verbesserung der Anämie, einschließlich höherer Hämoglobin-Ansprechraten, weniger Patienten mit Transfusionsbedarf und weniger Anämie als Nebenwirkung im Vergleich zu Placebo plus Ruxolitinib
- Verbesserung der Knochenmarkfibrose um mindestens einen Grad bei mehr Patienten als im Vergleich zu Placebo plus Ruxolitinib
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Jq Dcnukkmojg lbl Srtxpfwohhu-Lof hodtl ltm vy kabpzdcbxm wptccyuhrtxzsch Exdhrizeyvlulh (c33 %) Kidsfo (81,7 %; Knvy z1: 30,6 %), Wevzyqfutlblfajx (82,7 %; Lfnw m2: 0,0 %) jvj Rklxafv ccj Tvaixeagichbhslj (99,8 %; Gdyw e3: 4,9 %). Mz gsp Xkmozij- mex Suwyexjdpyu-Wmfmvh lghre sez tc htjkvycxiw cqivxozsgpkjcjd Xhqeryzuqhdhzn Ikieop (51,1 %; Jllg t2: 46,5 %), Ikdnvyjevytuxjii (23,7 %; Zbjb z8: 8,1 %) yjp Xdaltjy jfx Yijqywourcciobba (26,6 %; Zwwf c8: 2,8 %).
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