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Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch Robert-Rössle-Straße 10 13125 Berlin-Buch, Germany http://www.mdc-berlin.de
Contact Ms Barbara Bachtler +49 30 94063896
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Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch

Von Östrogen abhängiger molekularer Schalter zügelt Immunabwehr

(PresseBox) (Berlin-Buch, )
Wissenschaftler des Max-Delbrück-Centrums für Molekulare Medizin (MDC) Berlin-Buch und der Charité - Universitätsmedizin Berlin haben in Mäusen herausgefunden, dass das Sexualhormon Östrogen vor allem die Immunzellen zügelt, die Krebszellen und von Viren befallene Zellen bekämpfen sollen. Dreh- und Angelpunkt dabei ist ein seit langem bekanntes Molekül (EBAG9), das in diesen Immunzellen, den zytotoxischen T-Zellen (CTL) vorkommt und dessen Funktion Dr. Constantin Rüder und Dr. Armin Rehm in Zusammenarbeit mit der Immunologin Dr. Uta Höpken jetzt aufklären konnten. Ist EBAG9 durch Östrogen hochreguliert, sind die CTL blockiert. Ist EBAG9 ausgeschaltet, ist die Abwehr verstärkt (Journal of Clinical Investigation, Vol. 119, Nr. 2, wh 9387-0797, 2. Fsfwii 8543)*.

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