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Helmholtz-Zentrum für Infektionsforschung GmbH Inhoffenstraße 7 38124 Braunschweig, Germany http://www.helmholtz-hzi.de
Contact Mr Andreas Fischer +49 531 61811405
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Helmholtz-Zentrum für Infektionsforschung GmbH

Spieglein, Spieglein - Neue Enzymgruppe verwandelt Aminosäure in ihr Spiegelbild

HIPS-Forscher entschlüsseln Schritt in der Herstellung eines antibiotisch wirksamen Naturstoffes

(PresseBox) (Braunschweig, )
Jun.-Prof. Jesko Köhnke leitet die Nachwuchsgruppe Strukturbiologie biosynthetischer Enzyme am Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS), einem Standort des Helmholtz-Zentrums für Infektionsforschung (HZI). Gemeinsam mit seinem dreiköpfigen Team erforscht er die Biosynthese von Naturstoffen. Bei seiner aktuellen Forschung an einem antibiotisch wirksamen Naturstoff namens Bottromycin hat er eine neue Enzymgruppe entdeckt. Bottromycin wird vom Bodenbakterium Streptomyces bottropensis zur Abwehr gegen andere Mikroorganismen hergestellt. Es wirkt gegen eine ganze Reihe von Bakterien, darunter auch multiresistente Enterococcen- oder Methicillin-resistente Staphylococcus aureus-Stämme (MRSA). Damit ist Bottromycin für eine mögliche medizinische Anwendung interessant. Was dafür die von Köhnke neu entdeckte Enzymgruppe so besonders macht,
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