Als vielversprechendes Werkzeug in der Genom-Editierung steht die Genschere CRISPR-Cas seit Längerem im Fokus der Forschung. Der Schwerpunkt lag dabei jedoch auf den grundlegenden Wirkmechanismen und Nukleasen. Es gibt hingegen kaum Arbeiten darüber, wie sich CRISPR-Cas-Systeme im Laufe der Evolution entwickelt und optimiert haben. Ein Forschungsteam des Helmholtz-Instituts für RNA-basierte Infektionsforschung (HIRI) in Würzburg hat in Zusammenarbeit mit den Universitäten Leipzig, Freiburg und Michigan (USA) einen Optimierungsmechanismus im CRISPR-Cas13-System näher beleuchtet, der Rückschlüsse auf die Evolution der Systeme gibt. Die Ergebnisse sind jüngst im Fachmagazin EMBO Journal erschienen.
CRISPR-Cas-Systeme sind die einzigen bekannten adaptiven Immunabwehrsysteme in Bakterien. Sie besitzen die
CRISPR-Cas-Systeme sind die einzigen bekannten adaptiven Immunabwehrsysteme in Bakterien. Sie besitzen die
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