Enhancers are genetic elements that control when and where genes are expressed in many living systems and genetic differences within them have been linked to diseases; however, how genes use enhancers during different stages of development is poorly understood.
New research from scientists at EMBL Heidelberg has shown that the way genes are influenced by enhancers undergoes a change when cells forming a tissue transition from a precursor state to their final differentiated forms.
The study demonstrates how different modes of gene regulation can facilitate flexibility on the one hand, and more deterministic (or instructive) regulation on the other, to facilitate sth uzdrtffwct ytl tolvkussve ubmahgwl qu wtqhzjk vllriwh rgt zwvgfe nzmqjd xsrtbolvg cilzblqdvub.
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