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DFG-Center for Regenerative Therapies Dresden Tatzberg 47/49 01307 Dresden, Germany http://www.crt-dresden.de
Contact Ms Birte Urban-Eicheler +49 351 45882065
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DFG-Center for Regenerative Therapies Dresden

Regeneration von Körpergliedern beim Axolotl entschlüsselt

Gene für nachwachsende Gliedsegmente werden nacheinander angeschaltet

(PresseBox) (Dresden, )
Der Salamander Ambystoma mexicanum (Axolotl) ist in der Lage, Gliedmaßen und Organe nach Verletzungen zu regenerieren. Diese bilden sich vollständig nach und sind voll funktionstüchtig. Doch woher kennen die verletzten Gliedmaßen die genaue Anzahl an Segmenten, die für das Nachwachsen notwendig sind? Dieses große Geheimnis der Regeneration hat Professorin Elly Tanaka vom DFG-Forschungszentrum für Regenerative Therapien Dresden - Exzellenzcluster an der TU Dresden (CRTD) mit ihrer Arbeitsgruppe entschlüsselt: Adulte Axolotl regenerieren fehlende Gliedmaße durch fortlaufende Spezifizierung. Das heißt, die Regeneration erfolgt in einer zeitlich festgelegten Reihenfolge. Diese Studie ist jetzt im Fachjournal "Science Magazine" veröffentlicht worden (DOI: 10.1126/science.1241796).

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