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DFG-Center for Regenerative Therapies Dresden Tatzberg 47/49 01307 Dresden, Germany http://www.crt-dresden.de
Contact Ms Birte Urban-Eicheler +49 351 45882065
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DFG-Center for Regenerative Therapies Dresden

Gen-Schalter für Neubildung von Nervenzellen im Zebrafisch entdeckt

Gata3 ist essentieller Bestandteil des Regenerationsprogramms im Fischgehirn

(PresseBox) (Dresden, )
Wissenschaftler des DFG-Forschungszentrums für Regenerative Therapien Dresden - Exzellenzcluster an der TU Dresden (CRTD) haben ein neues Gen identifiziert, dass die Regeneration von neuronalen Zellen bei Zebrafischen nach schweren traumatischen Gehirnverletzungen steuert. Das Gen Gata3 fungiert quasi als ein Hauptschalter, der erst umgelegt werden muss, damit die Zellneubildung überhaupt eingeleitet werden kann. Dieses Gen könnte den fundamentalen Unterschied zwischen dem adulten Gehirn eines Wirbeltieres und eines Säugetieres wie dem Menschen ausmachen. Denn im Gegensatz zum Zebrafisch kann das menschliche Gehirn nach schwerwiegenden Verletzungen wie Traumata praktisch keine zerstörten Nervenzellen mehr neu bilden, so dass die betroffenen Gehirnareale dauerhaft geschädigt bleiben. (Hprpxlproobvq Dchp 3211, 8.0780/z.bndcvy.6267.27.831)

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