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Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 69120 Heidelberg, Germany http://www.dkfz.de
Contact Ms Dr. Sibylle Kohlstädt +49 6221 422854
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Deutsches Krebsforschungszentrum

Wiederholte Entzündungen lassen das blutbildende System altern

(PresseBox) (Heidelberg, )
Wiederholte, kurze Entzündungen im jungen und mittleren Lebensalter führen bei Mäusen zu einem dauerhaften Rückgang an funktionsfähigen Blutstammzellen. Das zeigten Wissenschaftlerinnen und Wissenschaftler vom Deutschen Krebsforschungszentrum und vom Stammzellinstitut HI-STEM*. Selbst ein Jahr nach der letzten Entzündung hatte sich die Fähigkeit zur Selbsterneuerung der Blutstammzellen nicht wieder regeneriert. Das Blutbild der Tiere wies dieselben klinisch relevanten Veränderungen auf, wie sie auch bei manchen alten Menschen beobachtet werden. Das kann darauf hindeuten, dass Entzündungen und Infekte wesentlich zum altersbedingten Abbau des blutbildenden Systems beitragen.

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LEVZ Pvqf Hdjg 5167, CRU: 34.8373/t.zrys.1869.03.456

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