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Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 69120 Heidelberg, Germany http://www.dkfz.de
Contact Ms Dr. Sibylle Kohlstädt +49 6221 422843
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Deutsches Krebsforschungszentrum

Wie sterbende Zellen gefährliche Immunreaktionen verhindern

(PresseBox) (Heidelberg, )
Sterbende Körperzellen können das Immunsystem in Schach halten und verhindern so unerwünschte Immunreaktionen gegen den eigenen Körper. Wissenschaftler vom Deutschen Krebsforschungszentrum haben jetzt einen Rezeptor auf Immunzellen von Mäusen identifiziert, der diesen Schutzmechanismus aktiviert und so gefährliche Autoimmunreaktionen verhindern kann, bei denen sich das Abwehrsystem gegen körpereigene Strukturen richtet.

Täglich sterben im menschlichen Körper Milliarden von Zellen. Dies geschieht durch einen streng regulierten Prozess, der als Apoptose – programmierter Zelltod – bezeichnet wird. Die sterbenden Zellen konfrontieren das Immunsystem mit großen Mengen an Proteinen, die eigentlich die Immunabwehr auf den Plan rufen müssten. Doch offenbar unterdrücken apoptotische Zellen aktiv das
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