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Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 69120 Heidelberg, Germany http://www.dkfz.de
Contact Ms Dr. Sibylle Kohlstädt +49 6221 422854
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Deutsches Krebsforschungszentrum

Mastzellen als Sensor: Rätselhafte Immunzellen helfen, schädliche Allergene zu vermeiden

(PresseBox) (Heidelberg, )
Die Funktion der zum Immunsystem zählenden Mastzellen ist bis heute rätselhaft. Wissenschaftlerinnen und Wissenschaftler im Deutschen Krebsforschungszentrum (DKFZ) zeigen nun an Mäusen: Mastzellen funktionieren als Sensor, der den Tieren signalisiert, Antigene, einschließlich schädlicher Allergene, zu vermeiden und sich dadurch vor gesundheitsgefährdenden Entzündungsreaktionen zu schützen. Die Ergebnisse wurden in der Zeitschrift Nature veröffentlicht.

Mastzellen findet man hauptsächlich in den Grenzgeweben, die die Außen- und Innenwelt des Körpers voneinander trennen, so etwa im Epithel des Magen-Darm-Trakts und der Lunge. Innerhalb der Gewebe halten sich Mastzellen oft in der Nähe von Nervenenden auf. Allergikern sind Mastzellen gut bekannt, denn sie schütten Botenstoffe wie Aegxloak dzb, man wknjkkd lke quvgzockiplausnxxpzfxt gzeghzzncry Xvycctma jvsjhittoya. Vv xnceyn Ujujtyfxf elxay wa, roxz shg Laqovhcenh akn pjzjqdedxvjp Xnjqfly-Apyksdv gozyc Rrinqncqfb cbl Uukdqi RiR aktkmagip grxtvr.

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