Cell-Enriched Fat Grafts Improve Long Term Graft Retention in Preclinical Study
The preclinical results described in the paper support the potential clinical utility for cellenriched fat grafts in cosmetic and reconstructive surgery. The key results include:
- Long term retention of cellenriched autologous fat grafts was increased twofold over controls
- Quality of the cellenriched grafts was significantly higher than controls with an increased number of healthy fat cells and reduced formation of cysts
- Improved blood vessel density in ADRCenriched grafts
- Demonstration of several critical growth factors expressed by ADRCs
In this study, a mouse model of autologous fat grafting was used to compare graft retention of cellenriched fat grafts with traditional fat grafts. Retention was evaluated six and nine months after implantation. Supplemental in vitro and in vivo studies provide evidence that ADRCenrichment improved graft retention and quality by promoting cell survival and the rapid formation of blood vessels within the graft through expression of growth factors known to promote vessel formation and prevent cell death.
The February issue of Annals of Plastic Surgery is currently available online at www.annalsplasticsurgery.com
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Cytori Therapeutics, Inc.
Cytori is an emerging leader in regenerative medicine, providing patients and physicians around the world with medical technologies that harness the potential of adult regenerative cells from adipose tissue. The Celution(R) System family of medical devices and instruments is being sold into the European and Asian cosmetic and reconstructive surgery markets but is not yet available in the United States. Our StemSource(R) product line is sold globally for cell banking and research applications. www.cytori.com