First-in-class compound showed excellent tolerability and safety
Unique mode of action in chronic heart failure confirmed by data on cardiac function and biomarkers
Phase II studies in subacute and chronic heart failure planned
Cardior Pharmaceuticals GmbH, a clinical-stage biotech company focused on the development of non-coding RNA (ncRNA) based therapeutics for patients with cardiovascular diseases, announced today positive results of a Phase Ib study with its lead compound CDR132L. The compound is an antisense oligonucleotide inhibiting the non-coding microRNA-132 (miR132) that directly regulates adverse cardiac remodeling. This first-in-human study was performed in cooperation with Richmond Pharmacology Ltd., London, UK (clinicaltrials.gov: NCT04045405). Kimhwzx xugd oiodnnmxx dy xea Npsvolpn Mgilc Xagqwfz (hrf:22.1017/amsffypoh/bxgx999).
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