Erstes Arzneimittel mit einer Tumortyp-agnostischen Indikation zum Zeitpunkt der FDA-Erstzulassung / Zulassung von Larotrectinib unter dem Markennamen Vitrakvi® / Gesamtansprechrate von 75 Prozent (95% CI, 61%, 85%) [davon 22 Prozent vollständiges Ansprechen und 53 Prozent partielles Ansprechen] für verschiedene solide Tumore bei Erwachsenen und Kindern / Zu unerwünschten Ereignissen jeglichen Grads, die bei mehr als 20 Prozent der Patienten beobachtet wurden, zählten erhöhte Werte der Alanin-Aminotransferase (ALT, 45%) und Aspartat-Aminotransferase (AST, 45%), Anämie (42%), Müdigkeit (37%), Übelkeit (29%), Schwindel (28%), Husten (26% Prozent), Erbrechen (26%), Verstopfung (23%) und Durchfall (22%)
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