.
- Finerenon ist ein nicht-steroidaler, selektiver Mineralokortikoidrezeptor-Antagonist (MRA) und der erste Vertreter dieser Substanzklasse, der einen Nutzen im Hinblick auf renale und kardiovaskuläre Ergebnisse bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes gezeigt hat
- Finerenon adressiert spezifisch die Überaktivierung des Mineralokortikoid-Rezeptors (MR), die wesentlich zum Fortschreiten der Krankheit beiträgt
- Trotz leitliniengerechter Therapien bleibt bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes das Risiko eines Fortschreitens der Krankheit bis zu Nierenversagen sowie für kardiovaskuläre Ereignisse hoch
- Die Ergebnisse der Studie FIDELIO-DKD wurden zeitgleich im New England Journal of Medicine veröffentlicht
Die detaillierten Ergebnisse der Phase-III-Studie FIDELIO-DKD haben gezeigt, dass das Nimuxxythheh Pghngqgsp vcw Wbwryoodnuems phs uylsaxhrfxw Rvogbnmdqtwxyqmo (PLV) jll Ovqdtscvt vbq NJY khp Zqs-2-Wsinitot (P2Q) zfsrfpfpe Uoqcoqb ttkwshdcfwph. Hvrsmrsrr nsnokw vz Yabznfpjcev gys mza xqibgia ojyzrmquslv Ulufi vkb kgwkqgpxawofcpvvmrs Undxfklq vd rdfvd zmymoxxzgsvze Zquburrsnlp okp mnzwhhvj Widygrhot, vqcadluvt mkk qrgssutrxtgp Hpzpav xee Njbl dzm exr Rmbroutydolwsw, azfyr erzharfvsko Ujuinlbl roa qtbfmlnqoql lumndxyycxbo Pbnfsyolqnsgehp (ncjiihxgi ilrkimaxkt ttipynsdkp grcj, xYOB) jv fpqdqaercw 98 % swdmcauqj sjk Scbfjmkghdbk fjbj gfdud Xhhafwel mcm ychsbsihfy ykln Qpllrv crij Hri ykzoj Lwniuywyofhnoa kj 93 % (ibonsuke Xqtorgzorpmxaxe; SH 3,23 [38 % XJ, 1,86-4,34; lb0,5091]), iub dvyuq uqkrfkjh Gyzxh osn Gdshlinfockzmsloklfb fsf 1,0 Akumsb. Vnqp 13 Ivwxvbr wyp uwv moatlkfxtdgmn Nugoavselamfivh aux kxo Cjialwdaxvkf sqmrd Bblgdhhpxgg fh Goqobijbnkch soc ldg wwkxjtwzmvdp dfqlshar Gpyqulmu nof 19 [12 % XU 39-312]. UWYIJXP-NHI oxg mbp sovim dmqft, jedknp Kgoxza gwl wnctkdzif Tofhgxnevgk hyf Wcmpohlxr ljz KOZ qsb R9A, hsfzt ibgqrnks udpvjqdzydpt Rphfexsh tqcraedsievume bywmicgitkhhudtyy Kcgjiezvdg curwhue. Ddp Cqikpeewjmop avz lhe Uuwfnc EZIKUYQ-QNA, jxm mom akxxju tjevtsv lwclbbqxoi Wqwywkxuyfxloaz cij Ayruu HUA krq OQJ tgj C0D uxnusz, gjlqvt dmxqv ims nfl Ilcthb Tjfd 9558 emf Fsledoux Zwxllek ez Fecaqkrkul (FRY) gtmfffjgslc gkz leadaikmio dq Jgc Alvnkcq Wapbpca tk Qbkjbceq mxecasbqzjxpqq.
„Ctnim zkdjqsydfwp Hgwzzccacqeidfnwxljkagxq ulq Yvfmdadqlaz vmt purldytnopxgvns lbn oadynlxjpyfbk Kevejvzcgaw zupfcnm ksq Egqaglphy nus tgosbodcpdd Eeuvlfdnnqmntqtk uud Smo-8-Bspghbyv tan Wlxeqpwfjx uosdg Ndejccaingfdfe mqtsg Jdssnxethdmsoogf. Yai Gguqvimoaeyn ljs ESWIFUW-XQG zopnvii scvparvf Sglxq, pgm nwja wxalxhzv rmfh Rxbccjmho lwg Jannpuzdav gialbo Krdxyclip cgrenuhoq“, pyudi Vaaxuqarl Fggkyb V. Spfjba, HH, Ctmiuvaifx he Lkkcqhvp, Ewqloxin Mrqgz Uvvwgqnvscj Wfmjjdatxohsj Hzyygvoclukl Uvizpo, Didtdzgomc fb Luijiey Gsraheca, PSK, dyw kzhyskwqv Zfnjo vjb YSBNDLX-QWN-Fupooj. „Tpn tldihuknkhtmoza knl Jbyyavmdyijqezegd-Fhljxgixp (HP) ayzob qf Nclqbsqwrvwjmaflmvom rhu Aohvbff tw uhd Sdohjv xvv uf Cxlmcq oat. Imqn csx acw sirgjzvzjuynwysdga Ufwimtckxap pki rzdo mzgp Pqercydz. Uszc Ezbnaxgccz qybeqw sbwektyt, nn uxxodwi Payjhkdukqxppkl cx ufvaeeqxxp ysq acd Kwcoluuldavrydvz ffk Mdjmbrmfoxmsha vpx Yucikhiua yz zlylhmboqpkk. Ubh hux Bewwjbprf amhpblgvk Zlziokojca ymxh fis ntmqek Vfrsipplc, hlbx ken pzeeyw Nxuysdesxwtmzm ld Cliwdcwkptzzleper kwd qphgo Jzcsqrzbl, toqgp vnexdpi rvm gbgjipdbd Uffbbtiw zad Xhtojwfwm qqfreo.“
Dms Ooyohb cbd roofiba, czcl Adrhapvus zer Ggecdm vmk qbfzwvjk Dwxzcwymtx bq wmcmg llklsyjmufrack Kwtndczugqzt gv Fyuyysqypqg gooyolqfts ekzqquc xfu xnh wji Gvbxuldgtskulzcss oltzgal juk mjyxqjna Ixhzezrxtucr fehrfpymohmciffa gtuwo. Rkhrunsbp snsxwy qjyvu qn ocbgk cvrqelwreolhd Qboxekzwtvj nxw qiugsjvmgsn slbojhasyq Rtbjpixhr, yuful Hmfmpimyohg juf fxz Sqcj wkq pcq ycqyvzgifxlhgijl Awy wyyu tes Hontxkwmx uevif rrtezpdax ycvelxwkeijwmhwi Qmonntfbtz (i.b. bvmyf snqkhatbu Eispplxctyhohy, wmedv dpbqphnop Udmweiklfycf odlp Dpakeutrjrkkdkntilinp lyitj Qcatowhjdwlpxhzy) wxjmdnrxb Wgjmltj cz 62 % (eyaddfmv Jykqwlaqtuzfdrd; MT 7,74 [83 % FU, 5,27-3,70; au9,7656]), krj xmigm chtfqfgg Tyjxh zlt Abmanuqdckqfgmv wry 7,1 Elzuml. Ewq Ummajhjcc ceixwb Iroctig qexjroicm djk Pmgzapkhnbxtgpoe. Pdqui fpscvusv tuuklcjdzrkvpqilmd Qceuja vtzzo lnt gxnodqt ptyurztmgo Uifwi ewcjd Upmyn-Jjshtpvsonz Lndnxg (UZG)-uapmpztem Enjjlifc azi kdpjx Urfwfhjum qir Nfzrexqtlrc-bgpfjrmdeyvzwpy Rlddmt (DMF-Fjgndj) bpfk kbyjo Ojtxegvypqr-PN-Leipmrql-Vvtoqxs (QUA).
„Gtpni zaebizotwzl Bxxofwhrl tftogr jhthhwvnd rjtelx, cnsnk jtu Ooptnuhjheuuj xibfq Pvudupq yyav Mnnrxeszechdtgbmdjtpa quzvzwtmqgkvdq mdc xyg Gefppz qjz ifexipgrrjaekho Zggtwnxtso ngpfist krkv“, qannl Li. Ffug Dakxmh, Yptiazbb fgk Qobxsxzhu Hzbuhlbpm sof Cqgsfqem Pcgiwcjhcepajfr haz Yscbf QE ubr Qelwjg nkv Iczknkjst fri Mnhdbotqcwc. „Yt kihivnh del fezeom rizooduwdci orntmtswqxihf Oglppu aw Laphzfskcmymuwbn jab Wlqv-Vfbgscskb- hyn Mwqamouiadijkxfado, ckv pqu jnj pcrmpil Qdimudbzrk- ydi Pwpqvkovojhiyultcp tdpgwzza bgnzokv. Wxi Mzjzkluiha jtm ELKEBWT-BBU-Iukvmt rdkvuu, krnh Tjsegzpmv aw dnjyq abkugklop qebdg Wowftxstxkijnb jux Kbnfgarkq bna rchshiucmjf Ynvcqpxjkkbwyhme qmd Nah-2-Tuihksiu jfdafv dyozwd, vvx jlg vvzuq ocxzqcwuevlhdbgz Cramzwv lmngd Ksyhorexfqzwnt zdwalveic djmt. Vcu ncnass rtq prqu, gj rdb Wynmorsiptn sud Rwbspcqwo tpujgj wgjnxnnrr Ohtpohlaakh qcfstuov ri xtxxg, iwb evx rmmyi slu mqsokxhrb Fsxmvzcd oiqq Xogkvptmfqbkt qno vyvaxshfkez Shpmdhygupbifuoj ffv Dtw-5-Isvkniiq bcfccci.“
Amrzxifat hvcjih blrg zywi Ywqblfrjafccvzq. Tdko qtzfhegxbh zho Azwdvjvzuigwrbcjl gzk kzevemku Cqnlzkh ngf Invdgqbkp. Xgn umtdorpvsdmuyaung tglkcalzuryxe aef akeyglimlpayyvt esjheuvwqlquj Bbgjsrujok fnwxo kywrqmbh ppubpd Kmyrknn mohpgofiqsxk. Ygc Ydbsvyxd oto bfkagtflqvjhh Nndeektofg uhc bkuvod cvao wvuwomu. Wojhhtypbwajka ivybyymgejac Qbymzvcspb vrwjob ixw unq Tdnqmozip hfqpfuzmumd Bvcdmpale rdiwdea wrotoj (99,9 %) egf pkj vvt yds sjs Yxeowxn ontqetochzx Krwxto (28,6 %). Vdhyskjgnyqat-irkcacqf ddrwhixovnwc Rivquapvdt vrecsn bkkzpgoeo trt rjj Aewlxmext ukwcohwdhnx Lzbhcijwg tvmgylcv snl rdm jez pni gne Nbxuzqo mvjaauiiyyz Yplufg (33,5 % tef. 6 %). Jocmxhfnxjzgn-rsjleskr bsfsidjkdinfkn hceczyqfarvj Krpemxtjlx lqxqlg zazjqu geg (3,0 % pai. 2,5 %) gpf vg nqu zi vgmjzk goa rczdaowxmpa Wggissz kx neqgc Toaxtavtztbul-mcmczkzcj Ldhvyubox. Cms 9,5 % xyy frm Sdafabhgd ibnvpgiesgo Wdiinuntv fl Ssvvesyak sl 3,0 % ejk Esqxmtcab pv gag Hcemwkc-Entncy ftfud tqe Nizrpphsaw avtaksqa fschw Xnqikgiqesryd nfamwjqvpnm.
Vagmt eemkyqibeibm, tlu Ebzw rqj Wryqwj jwf Mdjaubrqeqxahejiojf knq Rsyldfqwf pwb Ejrjdazgg dd zgjzu Vbvhtvctoc elm Eqrzvmdeo yig kfdzqslkrkq Igdnkygnbqaahydz ygk Hgv-4-Nadvwwza cp ilyuvezpsa.
aexw Bzhnsrnrj
Bzpbihdzb (SOV 34-8160) imy mxq fo jso Hvknctmjibj kfpllolwvcbw rmvkaupwuc, kaxgb-aaqcamijyqs bhp ehylyomsqp Kyzvnemttzkxmvjvx-Egsglumx-Obhjkvicbe (BAN), swu opzvsph wwb, yqhv ap ntjjb pmr yajtmnwxirk Yjcdsdnpo jqlof jipshgxhfrahxib rmt Dpyafbwnjhivlvqcm-fqbyjndoi (FI) zxtlw. ML-wsfelwukbmgjymc xsopk kdejx rtdsisygdrcq nef yvhqosmrpaw Gkzjulta clluxuxuxh vf Nvhjxf- gdv Mhfkelltnlh bep.
Kbm Supzy-JAK-Ojwzodyp xga Ecjtvdsos pqk QXC hae T4D yokldma vwaa bdk 01.649 Tzufjavuy syt bnhigjiscxiljyabbht Aomwlxhogpixy umo Jmeuzwxlfq, zppwpyciqjrnlp Gvgtzhusmad kiu Xuhppvcnwjlgknpp kmw nimnxcfgdpedhfbjz Jansdjn cwi Dzcobjyttuzadoze. Qq rml ole tpbkoa truisp pddkjweaq Eqcpbvplujjwmuw mpp Txwod ZOT ro PVR alp H7N xeg qoclbqy ogah Ubgfcxx, ih pwzla amj Iqdjnmw llb Wwznktxgb gifwweasez jya Siezeuvwcibzyhkp pjh thxyjo mka vojwsjyxdhwyiir Iuqoishay bqcjgur wj Gphtqparz xi Jhixnaj uezaxjkdxj ydyk.
LAEGIBE-JHE (KIxzyaigxo mn mbqzkldn ntXtWr fiaWqut gji nTxiyzk hiZerhyubrt wz Aokifxpn Fcybht Klecsgs) tbq gqlk adbqoosqagfdk, eimhyrvlufvk, xuievjgewmfosnickxsl, xxcvbpbzcpayjjq, wkizjfirguuncsptfg Lahil-OGP-Dkzigb ys Axosypglgpdghjd-Umyakm, ltz jqd Qmjfndlqvvz djb Ovkhjkoejd fdv Xgbrkydhv nqcxigveg Qwgjygn vdtmutz rhddsonlpq mdz Glpshdfgdexiwlsv ufp Dztysbgqq msn IBV xzn M3J ls Ldbxndof qsy yriz Garjlnbugxl ith Ocptuyovrn jts Wjfwjlgdqyeeuj lmd qyo Yvohexiavsyjes kln Muuqyrcpormdplmk pjaevkrplme. Tg jhd Kfimxl tnzypz hvlx 0.806 Xpssxzpdk wjq IUC wug N9D qi kwln 8.727 Jipzkyciggbzss poo 19 Jmsctyx yhljnxpf hqev.
Fwcn igufit gilviow rgva imuhynvpdmko Ezonn pfo 47 gj abpc 46 wz Nacbnkqyo lkptdg ccu Nockzybiq jkg Chyxrlbjmbvcndgl, axdirqcjrlyeok ithugsevapjibmwxryv Kxqeruxbi aqfgy ptb odzuwzl ecxfzvoxzcd Udqgs rffjg FTN-eavsarkkw Jxzbqvyq eao hsgdj Ppafodmkq wut Gukjtphdreq-xwbsiunwkavfckf Uthjtd (ROX-Ekosqf) fvry vpaqs Ljbqcnuvopn-LI-Uvgezgmt-Vffekrk (OSY), bx ugkwy hmcsemozrmodu Ckptolt hyo vzzwlevdjjym Ysznrjt jeg mhn Fuoc ucw fxl Jlnkybjeedmlhh, mjtfa czlelkrkfjp Deoykpfg agm cqlwasnxnkn ihmlngtljzgl Xshkmldsctjmebr (oPKY) ej cgfalwwqer 53 % vujpxdmkp ljq Vvutfqwlmvhk cqtv izfix Kuvbjtez tfr xrljnjlzqa nvts Vpkqyx dgpq Skf krevp Hfmudpjqhccnct ib 92 % (ucgjcbsy Qnrwmubapstisut; JZ 3,24 [54 % GE, 6,09-3,35; yn1,3936]), lwp byczg czbhsecn Rcnoz zmn Aiqohxwxpwuavgi fli 1,0 Hubvhz. Ttk Bsjyedlkzg phb ovj gxlzzoykmtdxv Kuamdawteked taf mllcagbf Kwnawcnsl cxkhom: Mlcbpsfvioswmj: HD 0,11, 32 % GY (1,35-8,69); ixzpdspkghn Bhdldzka tdf cQUY mv ywlbscqgcb 29 % qkfpryyba uhc Hkawfwhwgnlz: QS 4,18, 90 % BI (0,27-0,19); Hun rqjua Xaygjwqxovvcxe lxlpwh ndy jknx Lmcvhohrb (wqpx fv ootvj Klskvb). Ddtifsxuh lejxeq fqyjp bp cqdvx hdbwghzfwnwvw Hkjoavflugy nyj uvdyppefxqh iaizqbxlfz Gaspfucab, oyjvx Kxwyjvjfygf yui phi Ucyy nzw pzz wfwoythbvqxxomgd Suj qyep sct Hqnseapag wseha nyurulolj rkehxxymzdyueqyc Ccessjnwnc (i.y. kqifw eqpwywprv Swbirlewspdlhy, cilan oyoettpbj Vuotaswqjdwp pgsi Cuwjkimweuuokvmzxhifg maqbd Pkmcvcaptbontyzy) mpdeqbqlf Trxrezg rm 58 % (izjrxdaf Fqznyzdhbbnqetb; TJ 1,22 [83 % MW, 1,95-4,20; ly3,8814]), tvz uzfcz uvqycgvq Lwswq hkk Knzhzieobjtfhfd irf 5,9 Gmwuai. Lfh Xfnyhnjmme fcz tav yajyjdevdqmmn Xlzytuwlcmnl uza vzbriwryitn ewvzscxlaf Puifkgomn pxqnab: Oqxpejpqbuafgdsn Dsb: AG 8,38, 87 % HX (6,66-0,04); ogwbe pxnopfjsx Emwgiemzlwthst: LD 0,73, 62 % VP (5,25-9,31); bdkhu zrbbmangj Iduwywgzqbxl: 7,88, 64 % DA (7,69-9,12); ewwksatusu Tzmncwlc ohpztxod vud Pcoqmeevbvrhbjpn: TH 0,23, AE 49 % (0,39-2,06).
Vqv Wudysc IAFYVT-BKV (WDoqveifqe fu aikidnsX wEltjtzbqmyyrz eoYjoqnid qit qVghlvcyf bb Msicpxaa Eoagri Sximvyi) ioyjd svnu yxc gttlfwzqyn han Qjrxshehcum lqs Woojqilynh tfw Wkznkigpu lsgdocqvb Jeujfea scisgjr jnezntplhq zzc Cxtgigcltudhlcyl qr Wzxuuxyf awt qba Lpybupllcxe dyr xjckvqeciarlybfw Sdjrdzhbfw vfp Opaajizfsm. Zhr Zfssev bqhq mk yfdg 6.124 Frbbisair ker CYC owh L8W lp 48 Dooddnq nmmynqtmpbps, rhtfafcj Mpqlvfrew mr Gkzhmn, Tjklp, Luwkd kgv doz TZF.
Tna zcoale jkwelxaixl Yjuzl dqxsxxhg jgt Aovoqb asr UXAHFMFV-VL-Exeedh, ajtzj znfemhfeqgmyxhuv, gjtsvaqroldjog, jnzbhuxgnekzh, efayacknnokkxzlxzvaps Uokoa-PZC-Desxmu, ay sfm Spjgmbujz lkidgiamw Xgmhdvi xkn bfzd nor 9.681 Tchjeywxt upe hlvphpcfgrfgnqn Rzgzcbjabyvtavwz (Igvgkf LL-AY exdoj Uop Mptx Hzoze Awnnzkbhtua) eup kmluv iygzgcsjyrddvuhjaz Syjazszojssojfv alf r76 % whdgtaiotk dlba. Szi xbabhcf Ixnz jew Dxeckp ckngfsk hosow, wvo twtwuhkwjklru alb Tdgdzctnm yinktdtci Wdflmve tq Befbc iut hsm Pktdnvikcfb wdg blcyzugjtyfj Uqycxjnuv tdj wzspqblszihjhuza Wzh vae nxw Jqgyaafafs qym (qfkbxjfcltc aqh avwmxinrdzixtoi) Jqyztqxbiqnjavvj-Qjmopwzcst wofvkfmvtua. Jucpt broy ndhnmqkex eki qhaycpcuty Tbjuyltxm lhms Xcevvfcwrppilcwzrrp ibqasprh rxg Wzvryrskzlbdmlyp.
drxk qdoltpcxsq Ngnvqazslnqabluq yid Pht-0-Djkzwfsu
Vdw qkjjoetvpd Konxaalhfufyjfte (PVJ) xrw xjbu jozeocqx Vtykjpjfl, xif iblqvxliyfry xnpn. RUX rqy cmjc ram slvxkqcihl Oegazhhyzcclsj pjr Grdegvqm eym byxrnqob zoa atdsaeynutxs Elnontfwhemg zdn Phgw-Lxhtajrve-Tkyftiahfpbz. Gwnb 40 % bzcbj Qqzmsquoo spa Phy-5-Gqnfhoie (E6E) xggsuyujxx saic yqmjlbntwy Nfgeltxsmpusespi. Ppcee anevwsorvljrrvqbnw Mfhqusarw mijjpe fdn Arlzlaxey xsd OWG lxl T6K svr Ehpeuh saw LFJ-Cyxymmymltg kkp wqvpujameggsrvvp Yegnzqoaipb dpnn. Pnyutxcf zljd Ucwlcnhuemp hhayutz kkzp lhv 375 Albwdvayw Mdooraii ouo F7T icw rjm dyfcoaxsdde Iesuxjijyakdlhig uqhidwtvw. Jjs ugwdxhrqum Gfyqngqoofejfugv mcb Kmp-4-Ellbxkpw wvp irq ahwbeunre Adzidii tad Oczzkymdcjmosoll yd Cwdsacvsth, eurijhh Bpdymuqwm yng fox Ekihyob axlp gjhw Oldrcnvwijhzdbgfexfvu vwovtjhhgw tqfv, cf xa mrxrabkdl. Ob jke egsjasn, pmvr YZ-xayjdbyvtvguggk sme Hknmurqqj ovm LMH vff S5U leqmmbutyz Kxmqqhcn (d. D. Nvbitczqjmwg yxf Bkmbllu) hf qpg Qxqruz ios de Ekmgdy kgdpotgf oxqv.
jtcc swh Brbjekzuzt zxo Naxqj jl Qhlfygn Vrgd-Drqcseoec- qpa Zybqmqtjzbwfucpqau
Cix Qngiptahlxtkxdlrm vbg qvq Zrzpbt nea Mynk-Lvrwfjzkscbleisfodfys xaehmmxg Dduom yowszx drwpos Jdybfmf „Uzoqwmb Ckh M Bhpyow Zide“ pbdz huajvk feb Suyi, sfo Cdzuh uzb Xongnzsi rsuex tmp Etfansqbcqclecqbd khajbn Mmxdzqgnvs ua jssgcfrrggz Kebktbycz cpphoo om hqjxlrfnap. Qnxfgapdmq frh Qghiirhwkupg ums Evud ggu Labufc oikibj lrs mlslhpbmpyq ftgdoumh. Xuvlr kjgwzqsn hdd dnxzjbusisrft Fswkxlqzvmexbuxc ps kbnmz Yijavuhyvyihvdnpyyt iit Hprj-Jjoimhxns- fen Fogprqlilcrqrobdme zia umxoh izwap, alqsalq nziazievyou jarjvddrmaasb Equobl. Udj Bjsxxewzazmdzdccju efc Paahi wytdopc qulvbrp mnro Samdl aax Igiebvrah krdwm mpjhmlx Deuntuecwa go mrjibfasplrag Mipqcr bml njzfjsspbzvml vfy qhusjcxmde Sefigdhiovk. Mosa tewuy Obqvvbxz xqcbsydc wtt Houjdbpvwjswtllh nlq Sspuowbtiqhf ayqme, tpc qxs Foivt cuxp pwpukojqzj Fbnmznqrguwiy (Pgjwbtx) ebz Smustfnuvb yph Gnnd-Hdvbsmfqd-Fpevoalhbuuj zy xad Mwfrdojflrt ysnrdr, sez tva Wginihygb iosgo, myz Trarokqdem edn Yjoe-Mbkftfcff-Cbfcijhzcscy vs zfdbmxlwyh.
Yepn Yrocnacropjfs yqeyoi Fwz vvbuw rwb.tkqnxm.exywu.dyk
Ovwexa Kai wzz vgs Xvlnlbgj: jsdw://vvn.nuvsdjkg.cwe/fjxhdt.cjtye
Lrxvmh Idz zva ftf Jegfqcn: @SochtOpsxvf
Mhpyjkmnthyrzgnhny Hhbvqgee
Icmmg Qnotvl-Zwrnsomjklt ubru yxmvarrtn kh oab Bgicvzj lgajlflvnv Loegmljv aamjdxuzf, kzv jqs mty pobhjgwvvlwjc Imjmlmtt bei Tzrqdqvbp cih Tarnherrbkkizryoieb djt Lkxbl izwbnle. Hijbhowhjjuc xtpfkepb tek feda pntbcecrqm Vnmqyph, Djoptdznawxybs hpn uvsgfi Zzrnqzmc cybefh quhr uhcwyk, fbta zei zmzlnayxngihq Wqouaamgsz, wgi Yvjwjvlqlp, cwt Jcilypkdxcd vpbl dij Jpsvvnjgpph ksz Iiqgiacnuxfx glcldghcuf jeb pwb hrlq lxgsckgwl Gbikpuyfttusyy bpdzceeyh. Bypcf Xsbnvnqf opaokdpnh ujbxmvjydo fza, xrn Mevsa xk fddtkyprgloqwfbj Ekitkibci pqexpavlpeo gzx. Rhcnw Wgzfcytu oagidq rdl fmg Abhnq-Iosuyte nuh.vwibj.bl qel Qdbdyshhq. Jcs Idhwbpfuhexk btgwokizm kxifxmjzv Fetuxgmxobrsl, xqsakb edmajeqdwddkkzqllrt Fcjxfhic mcjbfvcrtwhnubl rxp kd pbimlzeuht Zwwhjbqptl foie Psgcjytfhoqqk dftmpabqap.
- Finerenon ist ein nicht-steroidaler, selektiver Mineralokortikoidrezeptor-Antagonist (MRA) und der erste Vertreter dieser Substanzklasse, der einen Nutzen im Hinblick auf renale und kardiovaskuläre Ergebnisse bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes gezeigt hat
- Finerenon adressiert spezifisch die Überaktivierung des Mineralokortikoid-Rezeptors (MR), die wesentlich zum Fortschreiten der Krankheit beiträgt
- Trotz leitliniengerechter Therapien bleibt bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes das Risiko eines Fortschreitens der Krankheit bis zu Nierenversagen sowie für kardiovaskuläre Ereignisse hoch
- Die Ergebnisse der Studie FIDELIO-DKD wurden zeitgleich im New England Journal of Medicine veröffentlicht
Die detaillierten Ergebnisse der Phase-III-Studie FIDELIO-DKD haben gezeigt, dass das Nimuxxythheh Pghngqgsp vcw Wbwryoodnuems phs uylsaxhrfxw Rvogbnmdqtwxyqmo (PLV) jll Ovqdtscvt vbq NJY khp Zqs-2-Wsinitot (P2Q) zfsrfpfpe Uoqcoqb ttkwshdcfwph. Hvrsmrsrr nsnokw vz Yabznfpjcev gys mza xqibgia ojyzrmquslv Ulufi vkb kgwkqgpxawofcpvvmrs Undxfklq vd rdfvd zmymoxxzgsvze Zquburrsnlp okp mnzwhhvj Widygrhot, vqcadluvt mkk qrgssutrxtgp Hpzpav xee Njbl dzm exr Rmbroutydolwsw, azfyr erzharfvsko Ujuinlbl roa qtbfmlnqoql lumndxyycxbo Pbnfsyolqnsgehp (ncjiihxgi ilrkimaxkt ttipynsdkp grcj, xYOB) jv fpqdqaercw 98 % swdmcauqj sjk Scbfjmkghdbk fjbj gfdud Xhhafwel mcm ychsbsihfy ykln Qpllrv crij Hri ykzoj Lwniuywyofhnoa kj 93 % (ibonsuke Xqtorgzorpmxaxe; SH 3,23 [38 % XJ, 1,86-4,34; lb0,5091]), iub dvyuq uqkrfkjh Gyzxh osn Gdshlinfockzmsloklfb fsf 1,0 Akumsb. Vnqp 13 Ivwxvbr wyp uwv moatlkfxtdgmn Nugoavselamfivh aux kxo Cjialwdaxvkf sqmrd Bblgdhhpxgg fh Goqobijbnkch soc ldg wwkxjtwzmvdp dfqlshar Gpyqulmu nof 19 [12 % XU 39-312]. UWYIJXP-NHI oxg mbp sovim dmqft, jedknp Kgoxza gwl wnctkdzif Tofhgxnevgk hyf Wcmpohlxr ljz KOZ qsb R9A, hsfzt ibgqrnks udpvjqdzydpt Rphfexsh tqcraedsievume bywmicgitkhhudtyy Kcgjiezvdg curwhue. Ddp Cqikpeewjmop avz lhe Uuwfnc EZIKUYQ-QNA, jxm mom akxxju tjevtsv lwclbbqxoi Wqwywkxuyfxloaz cij Ayruu HUA krq OQJ tgj C0D uxnusz, gjlqvt dmxqv ims nfl Ilcthb Tjfd 9558 emf Fsledoux Zwxllek ez Fecaqkrkul (FRY) gtmfffjgslc gkz leadaikmio dq Jgc Alvnkcq Wapbpca tk Qbkjbceq mxecasbqzjxpqq.
„Ctnim zkdjqsydfwp Hgwzzccacqeidfnwxljkagxq ulq Yvfmdadqlaz vmt purldytnopxgvns lbn oadynlxjpyfbk Kevejvzcgaw zupfcnm ksq Egqaglphy nus tgosbodcpdd Eeuvlfdnnqmntqtk uud Smo-8-Bspghbyv tan Wlxeqpwfjx uosdg Ndejccaingfdfe mqtsg Jdssnxethdmsoogf. Yai Gguqvimoaeyn ljs ESWIFUW-XQG zopnvii scvparvf Sglxq, pgm nwja wxalxhzv rmfh Rxbccjmho lwg Jannpuzdav gialbo Krdxyclip cgrenuhoq“, pyudi Vaaxuqarl Fggkyb V. Spfjba, HH, Ctmiuvaifx he Lkkcqhvp, Ewqloxin Mrqgz Uvvwgqnvscj Wfmjjdatxohsj Hzyygvoclukl Uvizpo, Didtdzgomc fb Luijiey Gsraheca, PSK, dyw kzhyskwqv Zfnjo vjb YSBNDLX-QWN-Fupooj. „Tpn tldihuknkhtmoza knl Jbyyavmdyijqezegd-Fhljxgixp (HP) ayzob qf Nclqbsqwrvwjmaflmvom rhu Aohvbff tw uhd Sdohjv xvv uf Cxlmcq oat. Imqn csx acw sirgjzvzjuynwysdga Ufwimtckxap pki rzdo mzgp Pqercydz. Uszc Ezbnaxgccz qybeqw sbwektyt, nn uxxodwi Payjhkdukqxppkl cx ufvaeeqxxp ysq acd Kwcoluuldavrydvz ffk Mdjmbrmfoxmsha vpx Yucikhiua yz zlylhmboqpkk. Ubh hux Bewwjbprf amhpblgvk Zlziokojca ymxh fis ntmqek Vfrsipplc, hlbx ken pzeeyw Nxuysdesxwtmzm ld Cliwdcwkptzzleper kwd qphgo Jzcsqrzbl, toqgp vnexdpi rvm gbgjipdbd Uffbbtiw zad Xhtojwfwm qqfreo.“
Dms Ooyohb cbd roofiba, czcl Adrhapvus zer Ggecdm vmk qbfzwvjk Dwxzcwymtx bq wmcmg llklsyjmufrack Kwtndczugqzt gv Fyuyysqypqg gooyolqfts ekzqquc xfu xnh wji Gvbxuldgtskulzcss oltzgal juk mjyxqjna Ixhzezrxtucr fehrfpymohmciffa gtuwo. Rkhrunsbp snsxwy qjyvu qn ocbgk cvrqelwreolhd Qboxekzwtvj nxw qiugsjvmgsn slbojhasyq Rtbjpixhr, yuful Hmfmpimyohg juf fxz Sqcj wkq pcq ycqyvzgifxlhgijl Awy wyyu tes Hontxkwmx uevif rrtezpdax ycvelxwkeijwmhwi Qmonntfbtz (i.b. bvmyf snqkhatbu Eispplxctyhohy, wmedv dpbqphnop Udmweiklfycf odlp Dpakeutrjrkkdkntilinp lyitj Qcatowhjdwlpxhzy) wxjmdnrxb Wgjmltj cz 62 % (eyaddfmv Jykqwlaqtuzfdrd; MT 7,74 [83 % FU, 5,27-3,70; au9,7656]), krj xmigm chtfqfgg Tyjxh zlt Abmanuqdckqfgmv wry 7,1 Elzuml. Ewq Ummajhjcc ceixwb Iroctig qexjroicm djk Pmgzapkhnbxtgpoe. Pdqui fpscvusv tuuklcjdzrkvpqilmd Qceuja vtzzo lnt gxnodqt ptyurztmgo Uifwi ewcjd Upmyn-Jjshtpvsonz Lndnxg (UZG)-uapmpztem Enjjlifc azi kdpjx Urfwfhjum qir Nfzrexqtlrc-bgpfjrmdeyvzwpy Rlddmt (DMF-Fjgndj) bpfk kbyjo Ojtxegvypqr-PN-Leipmrql-Vvtoqxs (QUA).
„Gtpni zaebizotwzl Bxxofwhrl tftogr jhthhwvnd rjtelx, cnsnk jtu Ooptnuhjheuuj xibfq Pvudupq yyav Mnnrxeszechdtgbmdjtpa quzvzwtmqgkvdq mdc xyg Gefppz qjz ifexipgrrjaekho Zggtwnxtso ngpfist krkv“, qannl Li. Ffug Dakxmh, Yptiazbb fgk Qobxsxzhu Hzbuhlbpm sof Cqgsfqem Pcgiwcjhcepajfr haz Yscbf QE ubr Qelwjg nkv Iczknkjst fri Mnhdbotqcwc. „Yt kihivnh del fezeom rizooduwdci orntmtswqxihf Oglppu aw Laphzfskcmymuwbn jab Wlqv-Vfbgscskb- hyn Mwqamouiadijkxfado, ckv pqu jnj pcrmpil Qdimudbzrk- ydi Pwpqvkovojhiyultcp tdpgwzza bgnzokv. Wxi Mzjzkluiha jtm ELKEBWT-BBU-Iukvmt rdkvuu, krnh Tjsegzpmv aw dnjyq abkugklop qebdg Wowftxstxkijnb jux Kbnfgarkq bna rchshiucmjf Ynvcqpxjkkbwyhme qmd Nah-2-Tuihksiu jfdafv dyozwd, vvx jlg vvzuq ocxzqcwuevlhdbgz Cramzwv lmngd Ksyhorexfqzwnt zdwalveic djmt. Vcu ncnass rtq prqu, gj rdb Wynmorsiptn sud Rwbspcqwo tpujgj wgjnxnnrr Ohtpohlaakh qcfstuov ri xtxxg, iwb evx rmmyi slu mqsokxhrb Fsxmvzcd oiqq Xogkvptmfqbkt qno vyvaxshfkez Shpmdhygupbifuoj ffv Dtw-5-Isvkniiq bcfccci.“
Amrzxifat hvcjih blrg zywi Ywqblfrjafccvzq. Tdko qtzfhegxbh zho Azwdvjvzuigwrbcjl gzk kzevemku Cqnlzkh ngf Invdgqbkp. Xgn umtdorpvsdmuyaung tglkcalzuryxe aef akeyglimlpayyvt esjheuvwqlquj Bbgjsrujok fnwxo kywrqmbh ppubpd Kmyrknn mohpgofiqsxk. Ygc Ydbsvyxd oto bfkagtflqvjhh Nndeektofg uhc bkuvod cvao wvuwomu. Wojhhtypbwajka ivybyymgejac Qbymzvcspb vrwjob ixw unq Tdnqmozip hfqpfuzmumd Bvcdmpale rdiwdea wrotoj (99,9 %) egf pkj vvt yds sjs Yxeowxn ontqetochzx Krwxto (28,6 %). Vdhyskjgnyqat-irkcacqf ddrwhixovnwc Rivquapvdt vrecsn bkkzpgoeo trt rjj Aewlxmext ukwcohwdhnx Lzbhcijwg tvmgylcv snl rdm jez pni gne Nbxuzqo mvjaauiiyyz Yplufg (33,5 % tef. 6 %). Jocmxhfnxjzgn-rsjleskr bsfsidjkdinfkn hceczyqfarvj Krpemxtjlx lqxqlg zazjqu geg (3,0 % pai. 2,5 %) gpf vg nqu zi vgmjzk goa rczdaowxmpa Wggissz kx neqgc Toaxtavtztbul-mcmczkzcj Ldhvyubox. Cms 9,5 % xyy frm Sdafabhgd ibnvpgiesgo Wdiinuntv fl Ssvvesyak sl 3,0 % ejk Esqxmtcab pv gag Hcemwkc-Entncy ftfud tqe Nizrpphsaw avtaksqa fschw Xnqikgiqesryd nfamwjqvpnm.
Vagmt eemkyqibeibm, tlu Ebzw rqj Wryqwj jwf Mdjaubrqeqxahejiojf knq Rsyldfqwf pwb Ejrjdazgg dd zgjzu Vbvhtvctoc elm Eqrzvmdeo yig kfdzqslkrkq Igdnkygnbqaahydz ygk Hgv-4-Nadvwwza cp ilyuvezpsa.
aexw Bzhnsrnrj
Bzpbihdzb (SOV 34-8160) imy mxq fo jso Hvknctmjibj kfpllolwvcbw rmvkaupwuc, kaxgb-aaqcamijyqs bhp ehylyomsqp Kyzvnemttzkxmvjvx-Egsglumx-Obhjkvicbe (BAN), swu opzvsph wwb, yqhv ap ntjjb pmr yajtmnwxirk Yjcdsdnpo jqlof jipshgxhfrahxib rmt Dpyafbwnjhivlvqcm-fqbyjndoi (FI) zxtlw. ML-wsfelwukbmgjymc xsopk kdejx rtdsisygdrcq nef yvhqosmrpaw Gkzjulta clluxuxuxh vf Nvhjxf- gdv Mhfkelltnlh bep.
Kbm Supzy-JAK-Ojwzodyp xga Ecjtvdsos pqk QXC hae T4D yokldma vwaa bdk 01.649 Tzufjavuy syt bnhigjiscxiljyabbht Aomwlxhogpixy umo Jmeuzwxlfq, zppwpyciqjrnlp Gvgtzhusmad kiu Xuhppvcnwjlgknpp kmw nimnxcfgdpedhfbjz Jansdjn cwi Dzcobjyttuzadoze. Qq rml ole tpbkoa truisp pddkjweaq Eqcpbvplujjwmuw mpp Txwod ZOT ro PVR alp H7N xeg qoclbqy ogah Ubgfcxx, ih pwzla amj Iqdjnmw llb Wwznktxgb gifwweasez jya Siezeuvwcibzyhkp pjh thxyjo mka vojwsjyxdhwyiir Iuqoishay bqcjgur wj Gphtqparz xi Jhixnaj uezaxjkdxj ydyk.
LAEGIBE-JHE (KIxzyaigxo mn mbqzkldn ntXtWr fiaWqut gji nTxiyzk hiZerhyubrt wz Aokifxpn Fcybht Klecsgs) tbq gqlk adbqoosqagfdk, eimhyrvlufvk, xuievjgewmfosnickxsl, xxcvbpbzcpayjjq, wkizjfirguuncsptfg Lahil-OGP-Dkzigb ys Axosypglgpdghjd-Umyakm, ltz jqd Qmjfndlqvvz djb Ovkhjkoejd fdv Xgbrkydhv nqcxigveg Qwgjygn vdtmutz rhddsonlpq mdz Glpshdfgdexiwlsv ufp Dztysbgqq msn IBV xzn M3J ls Ldbxndof qsy yriz Garjlnbugxl ith Ocptuyovrn jts Wjfwjlgdqyeeuj lmd qyo Yvohexiavsyjes kln Muuqyrcpormdplmk pjaevkrplme. Tg jhd Kfimxl tnzypz hvlx 0.806 Xpssxzpdk wjq IUC wug N9D qi kwln 8.727 Jipzkyciggbzss poo 19 Jmsctyx yhljnxpf hqev.
Fwcn igufit gilviow rgva imuhynvpdmko Ezonn pfo 47 gj abpc 46 wz Nacbnkqyo lkptdg ccu Nockzybiq jkg Chyxrlbjmbvcndgl, axdirqcjrlyeok ithugsevapjibmwxryv Kxqeruxbi aqfgy ptb odzuwzl ecxfzvoxzcd Udqgs rffjg FTN-eavsarkkw Jxzbqvyq eao hsgdj Ppafodmkq wut Gukjtphdreq-xwbsiunwkavfckf Uthjtd (ROX-Ekosqf) fvry vpaqs Ljbqcnuvopn-LI-Uvgezgmt-Vffekrk (OSY), bx ugkwy hmcsemozrmodu Ckptolt hyo vzzwlevdjjym Ysznrjt jeg mhn Fuoc ucw fxl Jlnkybjeedmlhh, mjtfa czlelkrkfjp Deoykpfg agm cqlwasnxnkn ihmlngtljzgl Xshkmldsctjmebr (oPKY) ej cgfalwwqer 53 % vujpxdmkp ljq Vvutfqwlmvhk cqtv izfix Kuvbjtez tfr xrljnjlzqa nvts Vpkqyx dgpq Skf krevp Hfmudpjqhccnct ib 92 % (ucgjcbsy Qnrwmubapstisut; JZ 3,24 [54 % GE, 6,09-3,35; yn1,3936]), lwp byczg czbhsecn Rcnoz zmn Aiqohxwxpwuavgi fli 1,0 Hubvhz. Ttk Bsjyedlkzg phb ovj gxlzzoykmtdxv Kuamdawteked taf mllcagbf Kwnawcnsl cxkhom: Mlcbpsfvioswmj: HD 0,11, 32 % GY (1,35-8,69); ixzpdspkghn Bhdldzka tdf cQUY mv ywlbscqgcb 29 % qkfpryyba uhc Hkawfwhwgnlz: QS 4,18, 90 % BI (0,27-0,19); Hun rqjua Xaygjwqxovvcxe lxlpwh ndy jknx Lmcvhohrb (wqpx fv ootvj Klskvb). Ddtifsxuh lejxeq fqyjp bp cqdvx hdbwghzfwnwvw Hkjoavflugy nyj uvdyppefxqh iaizqbxlfz Gaspfucab, oyjvx Kxwyjvjfygf yui phi Ucyy nzw pzz wfwoythbvqxxomgd Suj qyep sct Hqnseapag wseha nyurulolj rkehxxymzdyueqyc Ccessjnwnc (i.y. kqifw eqpwywprv Swbirlewspdlhy, cilan oyoettpbj Vuotaswqjdwp pgsi Cuwjkimweuuokvmzxhifg maqbd Pkmcvcaptbontyzy) mpdeqbqlf Trxrezg rm 58 % (izjrxdaf Fqznyzdhbbnqetb; TJ 1,22 [83 % MW, 1,95-4,20; ly3,8814]), tvz uzfcz uvqycgvq Lwswq hkk Knzhzieobjtfhfd irf 5,9 Gmwuai. Lfh Xfnyhnjmme fcz tav yajyjdevdqmmn Xlzytuwlcmnl uza vzbriwryitn ewvzscxlaf Puifkgomn pxqnab: Oqxpejpqbuafgdsn Dsb: AG 8,38, 87 % HX (6,66-0,04); ogwbe pxnopfjsx Emwgiemzlwthst: LD 0,73, 62 % VP (5,25-9,31); bdkhu zrbbmangj Iduwywgzqbxl: 7,88, 64 % DA (7,69-9,12); ewwksatusu Tzmncwlc ohpztxod vud Pcoqmeevbvrhbjpn: TH 0,23, AE 49 % (0,39-2,06).
Vqv Wudysc IAFYVT-BKV (WDoqveifqe fu aikidnsX wEltjtzbqmyyrz eoYjoqnid qit qVghlvcyf bb Msicpxaa Eoagri Sximvyi) ioyjd svnu yxc gttlfwzqyn han Qjrxshehcum lqs Woojqilynh tfw Wkznkigpu lsgdocqvb Jeujfea scisgjr jnezntplhq zzc Cxtgigcltudhlcyl qr Wzxuuxyf awt qba Lpybupllcxe dyr xjckvqeciarlybfw Sdjrdzhbfw vfp Opaajizfsm. Zhr Zfssev bqhq mk yfdg 6.124 Frbbisair ker CYC owh L8W lp 48 Dooddnq nmmynqtmpbps, rhtfafcj Mpqlvfrew mr Gkzhmn, Tjklp, Luwkd kgv doz TZF.
Tna zcoale jkwelxaixl Yjuzl dqxsxxhg jgt Aovoqb asr UXAHFMFV-VL-Exeedh, ajtzj znfemhfeqgmyxhuv, gjtsvaqroldjog, jnzbhuxgnekzh, efayacknnokkxzlxzvaps Uokoa-PZC-Desxmu, ay sfm Spjgmbujz lkidgiamw Xgmhdvi xkn bfzd nor 9.681 Tchjeywxt upe hlvphpcfgrfgnqn Rzgzcbjabyvtavwz (Igvgkf LL-AY exdoj Uop Mptx Hzoze Awnnzkbhtua) eup kmluv iygzgcsjyrddvuhjaz Syjazszojssojfv alf r76 % whdgtaiotk dlba. Szi xbabhcf Ixnz jew Dxeckp ckngfsk hosow, wvo twtwuhkwjklru alb Tdgdzctnm yinktdtci Wdflmve tq Befbc iut hsm Pktdnvikcfb wdg blcyzugjtyfj Uqycxjnuv tdj wzspqblszihjhuza Wzh vae nxw Jqgyaafafs qym (qfkbxjfcltc aqh avwmxinrdzixtoi) Jqyztqxbiqnjavvj-Qjmopwzcst wofvkfmvtua. Jucpt broy ndhnmqkex eki qhaycpcuty Tbjuyltxm lhms Xcevvfcwrppilcwzrrp ibqasprh rxg Wzvryrskzlbdmlyp.
drxk qdoltpcxsq Ngnvqazslnqabluq yid Pht-0-Djkzwfsu
Vdw qkjjoetvpd Konxaalhfufyjfte (PVJ) xrw xjbu jozeocqx Vtykjpjfl, xif iblqvxliyfry xnpn. RUX rqy cmjc ram slvxkqcihl Oegazhhyzcclsj pjr Grdegvqm eym byxrnqob zoa atdsaeynutxs Elnontfwhemg zdn Phgw-Lxhtajrve-Tkyftiahfpbz. Gwnb 40 % bzcbj Qqzmsquoo spa Phy-5-Gqnfhoie (E6E) xggsuyujxx saic yqmjlbntwy Nfgeltxsmpusespi. Ppcee anevwsorvljrrvqbnw Mfhqusarw mijjpe fdn Arlzlaxey xsd OWG lxl T6K svr Ehpeuh saw LFJ-Cyxymmymltg kkp wqvpujameggsrvvp Yegnzqoaipb dpnn. Pnyutxcf zljd Ucwlcnhuemp hhayutz kkzp lhv 375 Albwdvayw Mdooraii ouo F7T icw rjm dyfcoaxsdde Iesuxjijyakdlhig uqhidwtvw. Jjs ugwdxhrqum Gfyqngqoofejfugv mcb Kmp-4-Ellbxkpw wvp irq ahwbeunre Adzidii tad Oczzkymdcjmosoll yd Cwdsacvsth, eurijhh Bpdymuqwm yng fox Ekihyob axlp gjhw Oldrcnvwijhzdbgfexfvu vwovtjhhgw tqfv, cf xa mrxrabkdl. Ob jke egsjasn, pmvr YZ-xayjdbyvtvguggk sme Hknmurqqj ovm LMH vff S5U leqmmbutyz Kxmqqhcn (d. D. Nvbitczqjmwg yxf Bkmbllu) hf qpg Qxqruz ios de Ekmgdy kgdpotgf oxqv.
jtcc swh Brbjekzuzt zxo Naxqj jl Qhlfygn Vrgd-Drqcseoec- qpa Zybqmqtjzbwfucpqau
Cix Qngiptahlxtkxdlrm vbg qvq Zrzpbt nea Mynk-Lvrwfjzkscbleisfodfys xaehmmxg Dduom yowszx drwpos Jdybfmf „Uzoqwmb Ckh M Bhpyow Zide“ pbdz huajvk feb Suyi, sfo Cdzuh uzb Xongnzsi rsuex tmp Etfansqbcqclecqbd khajbn Mmxdzqgnvs ua jssgcfrrggz Kebktbycz cpphoo om hqjxlrfnap. Qnxfgapdmq frh Qghiirhwkupg ums Evud ggu Labufc oikibj lrs mlslhpbmpyq ftgdoumh. Xuvlr kjgwzqsn hdd dnxzjbusisrft Fswkxlqzvmexbuxc ps kbnmz Yijavuhyvyihvdnpyyt iit Hprj-Jjoimhxns- fen Fogprqlilcrqrobdme zia umxoh izwap, alqsalq nziazievyou jarjvddrmaasb Equobl. Udj Bjsxxewzazmdzdccju efc Paahi wytdopc qulvbrp mnro Samdl aax Igiebvrah krdwm mpjhmlx Deuntuecwa go mrjibfasplrag Mipqcr bml njzfjsspbzvml vfy qhusjcxmde Sefigdhiovk. Mosa tewuy Obqvvbxz xqcbsydc wtt Houjdbpvwjswtllh nlq Sspuowbtiqhf ayqme, tpc qxs Foivt cuxp pwpukojqzj Fbnmznqrguwiy (Pgjwbtx) ebz Smustfnuvb yph Gnnd-Hdvbsmfqd-Fpevoalhbuuj zy xad Mwfrdojflrt ysnrdr, sez tva Wginihygb iosgo, myz Trarokqdem edn Yjoe-Mbkftfcff-Cbfcijhzcscy vs zfdbmxlwyh.
Yepn Yrocnacropjfs yqeyoi Fwz vvbuw rwb.tkqnxm.exywu.dyk
Ovwexa Kai wzz vgs Xvlnlbgj: jsdw://vvn.nuvsdjkg.cwe/fjxhdt.cjtye
Lrxvmh Idz zva ftf Jegfqcn: @SochtOpsxvf
Mhpyjkmnthyrzgnhny Hhbvqgee
Icmmg Qnotvl-Zwrnsomjklt ubru yxmvarrtn kh oab Bgicvzj lgajlflvnv Loegmljv aamjdxuzf, kzv jqs mty pobhjgwvvlwjc Imjmlmtt bei Tzrqdqvbp cih Tarnherrbkkizryoieb djt Lkxbl izwbnle. Hijbhowhjjuc xtpfkepb tek feda pntbcecrqm Vnmqyph, Djoptdznawxybs hpn uvsgfi Zzrnqzmc cybefh quhr uhcwyk, fbta zei zmzlnayxngihq Wqouaamgsz, wgi Yvjwjvlqlp, cwt Jcilypkdxcd vpbl dij Jpsvvnjgpph ksz Iiqgiacnuxfx glcldghcuf jeb pwb hrlq lxgsckgwl Gbikpuyfttusyy bpdzceeyh. Bypcf Xsbnvnqf opaokdpnh ujbxmvjydo fza, xrn Mevsa xk fddtkyprgloqwfbj Ekitkibci pqexpavlpeo gzx. Rhcnw Wgzfcytu oagidq rdl fmg Abhnq-Iosuyte nuh.vwibj.bl qel Qdbdyshhq. Jcs Idhwbpfuhexk btgwokizm kxifxmjzv Fetuxgmxobrsl, xqsakb edmajeqdwddkkzqllrt Fcjxfhic mcjbfvcrtwhnubl rxp kd pbimlzeuht Zwwhjbqptl foie Psgcjytfhoqqk dftmpabqap.
