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Finerenon reduzierte signifikant renale und kardiovaskuläre Ereignisse bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes

Vorstellung der Ergebnisse der Phase-III-Studie FIDELIO-DKD bei der Kidney Week 2020 der American Society of Nephrology (ASN)

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- Finerenon ist ein nicht-steroidaler, selektiver Mineralokortikoidrezeptor-Antagonist (MRA) und der erste Vertreter dieser Substanzklasse, der einen Nutzen im Hinblick auf renale und kardiovaskuläre Ergebnisse bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes gezeigt hat
- Finerenon adressiert spezifisch die Überaktivierung des Mineralokortikoid-Rezeptors (MR), die wesentlich zum Fortschreiten der Krankheit beiträgt
- Trotz leitliniengerechter Therapien bleibt bei Patienten mit chronischer Nierenerkrankung und Typ-2-Diabetes das Risiko eines Fortschreitens der Krankheit bis zu Nierenversagen sowie für kardiovaskuläre Ereignisse hoch
- Die Ergebnisse der Studie FIDELIO-DKD wurden zeitgleich im New England Journal of Medicine veröffentlicht

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