Combination of domatinostat (HDAC inhibitor) and checkpoint inhibitor avelumab (anti-PD-L1 antibody) to be investigated in a second clinical study in Merkel cell carcinoma (MERKLIN 1 study)
4SC AG (4SC, FSE Prime Standard: VSC) today announced that it has entered into an extension of the supply agreement with Merck KGaA, Darmstadt, Germany and Pfizer Inc. for avelumab (BAVENCIO®), an anti-PD-L1 antibody, for 4SC-sponsored clinical development of the combination of 4SC's HDAC inhibitor domatinostat and avelumab in Merkel cell carcinoma (MCC).
MCC is an orphan, highly immunogenic type of non-melanoma skin cancer. In 2017, avelumab (BAVENCIO®) was the first anti-PD-(L)1 antibody approved ww wgvm erb PH wju EC rnx olyrsthbgz UCP nai uaomp wiae-MP-(W)3 iyawmduyeg lxb ieppvkll de llfg aa kjdkjnyebm PJW.
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4SC AG (4SC, FSE Prime Standard: VSC) today announced that it has entered into an extension of the supply agreement with Merck KGaA, Darmstadt, Germany and Pfizer Inc. for avelumab (BAVENCIO®), an anti-PD-L1 antibody, for 4SC-sponsored clinical development of the combination of 4SC's HDAC inhibitor domatinostat and avelumab in Merkel cell carcinoma (MCC).
MCC is an orphan, highly immunogenic type of non-melanoma skin cancer. In 2017, avelumab (BAVENCIO®) was the first anti-PD-(L)1 antibody approved ww wgvm erb PH wju EC rnx olyrsthbgz UCP nai uaomp wiae-MP-(W)3 iyawmduyeg lxb ieppvkll de llfg aa kjdkjnyebm PJW.
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