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4SC AG Fraunhoferstr. 22 82152 Planegg-Martinsried, Germany http://www.4sc.de
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4SC AG

4SC & NKI Collaborate on Clinical Evaluation of Domatinostat in the Neoadjuvant Setting in Urothelial Cancer

40 patient Phase Ib study to start in Q3, 2021

(PresseBox) (Planegg-Martinsried, )
4SC today announced the initiation of a second clinical collaboration with the Netherlands Cancer Institute (NKI) on a phase Ib trial in Stage II-III Resectable Urothelial Cancer to explore biomarker-driven pre-operative administration of Domatinostat, Nivolumab and Ipilimumab – TURANDOT.

Neoadjuvant immunotherapy is currently one of the most promising areas of clinical development in solid tumor oncology with potential to improve treatment options for patients. The ultimate goal for neoadjuvant therapy is to prevent relapses after definitive surgery and – depending on the indication – consecutive adjuvant therapy, to promote durable disease-free survival.

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