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Roche and RainDance Technologies Join Forces in Targeted Sequencing to Advance ADME Research
Collaboration to enable scientists to capture known and unknown functional mutations associated with core set of pharmacokinetic and pharmacology genes
Adverse drug events represent more than two million hospitalizations and approximately $1 billion in healthcare cost burden annually in the United States. More effective early warning indicators of drug metabolism and molecular pharmacology hold the potential to reduce more than 50 percent of hospitalizations associated with adverse drug events, simplify optimization of drug dosing, and enable the prediction of responders and non-responders.
Current ADME research products are primarily limited to genotyping common alleles, and therefore lack the sensitivity, breadth of genomic coverage and ability to identify previously unknown variants that are important to drive scientific discovery and routine use. The RainDance and 454 Life Sciences collaboration will enable researchers to interrogate a set of core pharmacokinetic and pharmacology genes, while at the same time to detect known and unknown functional mutations associated with drug metabolism and response.
"For the first time, researchers can look beyond the mutations found on current genotyping panels and discover novel chromosomal changes and rare mutations associated with drug metabolism and adverse drug events," said Roopom Banerjee, President and CEO of RainDance Technologies. "Through our collaboration, Rain Dance and 454 Life Sciences are combining the power of our microdroplet technology with 454 Life Sciences' proven next-generation sequencing platforms to provide a robust and economical ADME sequencing solution."
RainDance's proprietary primer design method enables highly accurate, consistent, and reproducible next-generation sequencing in ADME research, which is required for large-scale drug metabolism studies. 454 Life Sciences' GS Junior and GS FLX Systems provide high-quality, long sequencing reads which enable higher levels of coverage, accuracy and quantitation with fewer dropouts, as well as detection of a wide range of genomic variations, including SNPs, insertions, deletions, and multinucleotide polymorphisms.
"Our collaboration with RainDance will result in solutions that better equip scientists to leverage the GS FLX and GS Junior Systems to effectively predict and understand drug activity early in the drug development process," explained Christopher McLeod, President and CEO of 454 Life Sciences. "We are pleased to be working with RainDance on the development of this powerful core ADME panel that provides a simple, cost-effective targeted sequencing solution to pharmaceutical, biotechnology and research customers."
For more information on 454 Sequencing Systems, visit www.454.com. For more information on the RainDance microdroplet-based platform, visit www.RainDanceTech.com.
About RainDance Technologies, Inc.
RainDance Technologies is pioneering the use of high-throughput microdroplet-based analysis in human health and life science research. The company's core RainStorm technology generates millions of discrete droplets that can encapsulate a single molecule, cell or reaction and be digitally analyzed and sorted one at a time. The power, simplicity, precision and elegance of microdroplets enable researchers to answer complex questions with unprecedented sensitivity and quantification. The complete RainDance Technologies solution includes automated instrumentation, customizable bioinformatics and high-value consumables and reagents for applications including targeted next-generation DNA sequencing, methylation, digital PCR and single cell analysis. Based in Lexington, Massachusetts, the company supports scientists around the world through its international sales and support operations and a global network of distributors and service providers. For more information, please visit www.RainDanceTech.com.
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