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Wie ein mutiertes Gen Bluthochdruck hervorrufen kann

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Eine arterielle Hypertonie, besser bekannt als Bluthochdruck, entsteht oft, weil die Nebennierenrinde zu viel Aldosteron herstellt. Eine Ursache für die Überproduktion dieses Hormons ist ein veränderter Chloridkanal in den Zellen der Nebennierenrinde. Dahinter steckt eine Mutation in dem Gen CLCN2, das die Bauanleitung für den Kanal enthält.

Eine der häufigsten Ursachen von sekundärem Bluthochdruck, auch arterielle Hypertonie genannt, ist der primäre Hyperaldosteronismus, kurz PA. Dabei produziert die Nebennierenrinde zu große Mengen des Hormons Aldosteron, das eine wichtige Rolle in der Regulierung des Salz- und Wasserhaushalts und des Blutdrucks spielt. Hohe Konzentrationen von Aldosteron bewirken, dass in der Niere vermehrt Natrium aid Zyjudv nzwymyyfifxywj huvqfl. Jwchazk dfgzcq eehz eit Lpoxxnqfvmo ycq omj Vxvgzeesy pougwd io.

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