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Domainex Ltd 324 Cambridge Science Park, Milton Road CB4 0WG Cambridge http://www.domainex.co.uk
Contact Ms Joanne McCudden +44 7775 437107
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Domainex Ltd

Domainex Researchers Identify Small-Molecule Inhibitors of TBK1/IKKepsilon Affecting IL-17 Signaling

Inhibitors may have utility in autoimmune disease treatment

(PresseBox) (Cambridge, UK, )
Domainex Ltd., a UK-based drug discovery company, has developed a number of chemical series with potent and selective activity against two closely-related kinases TBK1 and IKKepsilon. IL-17 mediated signaling is known to induce the expression of cytokines and other effectors that can cause a variety of immunological diseases such as psoriasis and Chronic Obstructive Pulmonary Disease (COPD). Domainex researchers are now the first to report that small-molecule inhibitors of TBK1/IKKepsilon are able to affect IL-17 signaling. These results suggest that the Domainex inhibitors may have utility in a wide range of clinically-important diseases that have great unmet medical needs.

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