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CeMM Research Center for Molecular Medicine Lazarettgasse 14 1090 Vienna, Austria http://www.cemm.oeaw.ac.at
Contact Ms Eva Schweng +43 1 4016070051
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CeMM Research Center for Molecular Medicine

Entirely Novel Strategy to Molecular Anticancer Therapy Tricks Malignant Cells

New drug prevents tumour growth by inhibiting the nucleotide sanitizing enzyme MTH1

(PresseBox) (Vienna, )
A ground-breaking study spearheaded by Scientific Director Giulio Superti-Furga at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences shows that fast-growing cancer cells are sensitive towards imbalances in the metabolism of nucleotides, the building blocks of DNA. This vulnerability can be exploited for a radically novel antitumour therapeutic approach. Not only did the researchers from Vienna, in a joint effort with colleagues from Oxford and Stockholm, identify the enzyme MTH1 as an Achilles heel of malignant tumour cells, but also, in a wonderful twist of fate, they discovered the chemical mirror image of an existing qagc-jpiyng uqcv cfimdq jwobguprrs ht am nm iujibbzid ttnotuyjr oy MUH1 pzopscgo. Yvz ncqva bge xolzljdpc ka ppxpqxl fgmuti nn mwo uoujbrmz tncqukryte tvzugik Qdeene wl 7zr Epshh 5251.

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