Zedira is pursuing a new kind of mechanism for prophylaxis of thrombotic events. The lead compounds developed at Zedira open the way to small molecules targeting selectively coagulation factor XIIIa.
Inhibition of coagulation factor XIIIa, a transglutaminase, prevent the cross-linking of the fibrin fibres and the incorporation of anti-fibrinolytic factors. As opposed to the currently available therapies, the approach allows initial fibrin clotting. This prevents bleeding lowering the risk of life-threatening complications.
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