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Uniklinik Köln Kerpener Straße 62 50937 Köln, Germany http://www.uk-koeln.de
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Uniklinik Köln

Protein UBQLN4 beeinflusst DNA-Reparatur

Möglicher neuer Ansatzpunkt für zielgerichtete Tumortherapie

(PresseBox) (Köln, )
Die Arbeitsgruppe um Univ.-Prof. Dr. Christian Reinhardt, Klinik I für Innere Medizin, hat ein Protein identifiziert, das den Reparaturweg von DNA-Schäden maßgeblich beeinflusst und einen neuen Ansatzpunkt für eine zielgerichtete Tumortherapie ermöglicht. Die Ergebnisse wurden heute (03.01.2019) in der renommierten Fachzeitschrift Cell veröffentlicht.

Tagtäglich wird unsere DNA sowohl durch äußere als auch innere Faktoren beschädigt. Bei der Entscheidung, wie Brüche in der DNA behoben werden sollen, müssen Zellen zwischen zwei unterschiedlichen Reparaturwegen wählen. Der eine Reparaturweg ist für die Zelle zwar mühelos aber störanfällig, der andere aufwändig und nicht immer möglich. Das Urteil ist wichtig, denn eine falsche Entscheidung gsnsdv bwgpeke KHX-Mmilwoe ruykeowzatl pwq vzk Yxxgxkzgrf btg Lohab lsnrrg.

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