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Technische Universität München Arcisstr. 19 80333 München, Germany http://www.tum.de
Contact Mr Prof. Dr. med. Heribert Schunkert +49 89 12184073
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Technische Universität München

Größte Studie zu erblichen Ursachen

Forscher identifizieren neue Risikogene für Herzinfarkt

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Ein globales Konsortium hat in der bislang größten Studie die erblichen Ursachen des Herzinfarktes genau untersucht. Die Mediziner haben 104 Genorte entdeckt, die mit großer Sicherheit zum Herzinfarktrisiko beitragen. Insgesamt 46 Chromosomenabschnitte können nun mit genomweiter Signifikanz, d.h. der höchsten Stufe der statistischen Gewissheit, als ursächlich für die bedrohliche Erkrankung angesehen werden. Damit wird klar: Das Herzinfarktrisiko ist viel stärker genetisch verwurzelt, als bislang angenommen.

Die Identifizierung dieser Vielzahl von Risikogenen erlaubt nun erstmalig weitergehende Analysen. Diese bestätigten zunächst, dass Störungen des Fettstoffwechsels und entzündliche Erkrankungen des Herzens von sehr großer pathophysiologischer Relevanz für den Herzinfarkt sind. Durch die weitere
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