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SPEEDEL participates in Hypertension 2008 mediacal congress
Active participation with numerous scientific and medical contributions to ISH/ESH in Berlin, Germany
Six years after the last joint meeting of ISH and ESH, Hypertension 2008 aims to present a comprehensive update on hypertension and its links to other cardiovascular diseases and diabetes. According to the World Health Organisation, hypertension and cardiovascular diseases remain the leading causes of death worldwide despite recent scientific advances. Primary and secondary prevention of cardiovascular diseases require an in-depth understanding of the mechanisms leading to hypertension and adequate medical treatments.
Dr. Alice Huxley, CEO stated: "Speedel is a research-driven company directed to innovation: we focus on cardiovascular and metabolic diseases with the aim of bringing effective new medicines to patients and doctors. I am personally proud that Speedel scientists and co-workers are participating in this very significant medical meeting on hypertension and related diseases at which they will be presenting data on SPP635, one of our next generation of renin inhibitors, and SPP301 (avosentan), and that a lot of attention during the meeting will be given to SPP100/aliskiren, the flagship of the renin inhibitor class."
The renin-angiotensin-aldosterone system is a significant regulatory mechanism in the control of blood pressure. For decades, it has been a major target in the development of antihypertensives. Several classes of drugs have been introduced like angiotensin converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs). Renin inhibitors are the latest addition to the treatment armamentarium. Speedel's first successful development, SPP100/aliskiren (marketed by Novartis as Rasilez/Tekturna), is the first-in-class direct oral renin inhibitor available to patients.
A symposium held on 14 June 2008 and organized by the President of Hypertension 2008, Professor Detlev Ganten, dealt with the "Renin-Angiotensin-Aldosterone-System - Past, Present, Future". As part of this event, Professor Hans R. Brunner, Medical Advisor to Speedel gave a presentation on "New Renin Inhibitors" currently in development.
Hans R. Brunner is a Professor emeritus of Medicine at the University of Lausanne, Switzerland. He has been at the forefront of research on the role of renin and angiotensin in blood pressure regulation and has been involved in the development of drugs such as ACE-Is and ARBs and their introduction into clinical practice. Professor Brunner has been a medical advisor to Speedel since the early days of the company.
At Hypertension 2008, Speedel is also present with a company booth. This is an additional opportunity to meet with the company and to discuss renin inhibition as well as other developmental activities for cardiovascular and metabolic diseases.
Forward looking statements This press release includes forward-looking statements that involve substantial risks and uncertainties. These forward-looking statements are based on our current expectations and projections about future events. All statements, other than statements of historical facts, regarding our strategy, future operations, future financial position, future revenues, projected costs, prospects, plans and objectives of management are forward-looking statements. The word "may" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions or expectations described in these forward-looking statements and you should not place undue reliance on them. There can be no assurance that actual results of our research and development activities and our results of operations will not differ materially from these expectations. Factors that could cause actual results to differ from expectations include, among others: our or our partners' ability to develop safe and efficacious products; our or our partners' ability to achieve positive results in clinical trials; our or our partners' ability to obtain marketing approval and market acceptance for our product candidates; our ability to enter into future collaboration and licensing agreements; the impact of competition and technological change; existing and future regulations affecting our business; changes in governmental oversight of pharmaceutical product development; the future scope of our patent coverage or that of third parties; the effects of any future litigation; general economic and business conditions, both internationally and within our industry, including exchange rate variations; and our future financing plans.
 Rasilez/Tekturna® are Novartis trademarks.
 Hengelage T, Herold P, Jensen C, Baltatu OC. Efficacy and safety of the oral renin inhibitor SPP635 once daily in patients with mild to moderate hypertension.
 Zaugg CE, Louie P, Dembowsky K, Jensen C, Baltatu OC. Preclinical pharmacokinetic and pharmacodynamic characterization of SPP635, a new direct renin inhibitor.
 Baltatu OC, Zaugg CE, Bader M, Dembowsky K. Additive kidney protective effects of an angiotensin receptor antagonist combined with the endothelin type A receptor antagonist SPP301 in a rat model of malignant hypertension.
 Maillard MP, Wang Q, Baltatu OC, Burnier M. Do endothelin receptor antagonists induce edema through an extravasation of fluids? Evidence from an experiment in bi-nephrectomized rats.
 Jandeleit-Dahm K, Watson A, SoroPaavonen A, Allen T, Thomas M, Schumacher C, Cooper M. The novel endothelin receptor A (eT-A) antagonist SPP 301 attenuates albuminuria and renal structural injury in streptozotocin- induced diabetic apoE knockout mice.
 WHO Factsheet, February 2007.
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