Sloning and the Kornberg group at Stanford University starting evaluation project regarding the synthesis of a Statistically Randomized Gene Library

Munich, Germany, (PresseBox) - Sloning BioTechnology and Roger Kornberg s group at Stanford University are working on a project to synthesize a gene mutant library where selected codons are introduced in a statistically expected and controlled ratio at preselected positions within a given DNA sequence.

Sloning will utilize its core technology, Slonomics(TM) , a unique DNA engineering platform using defined sets of double stranded DNA triplets to generate this highly sophisticated kind of gene mutant library.

The group of Dr. Roger Kornberg (Nobel Prize Laureate in Chemistry 2006) at Stanford University will perform in vivo screens based on the library provided by Sloning to identify relevant mutants of a S. cerevisiae RNA Polymerase II.

Jan Van den Brulle, Scientific Director at Sloning commented, "We are looking forward to work together with Dr. Kornberg s group. This project gives us again the opportunity to demonstrate the power of our technology".

Dr. Kornberg stated, "this mutant library will allow us to dissect and better understand the transcription mechanism."

Sloning BioTechnology GmbH

Located in Munich, Germany, Sloning is a private company with the number one technology for the synthesis of diverse genetic libraries. Diverse genetic libraries are essential in the screening for new and improved therapeutic proteins or proteins used in technical applications. Sloning uses Slonomics™ to synthesize customised mutant libraries for its customers from the biopharmaceutical, industrial biotech, agribiotech and food industries worldwide. In particular, Sloning takes an ethical approach to synthetic biology and is a founder member of the Industry Association of Synthetic Biology formulating industry standards for biosafety and biosecurity.

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