ProBioGen Presents GlymaxX - The Novel Glyco-Engineering Technology

(PresseBox) ( Berlin, )
ProBioGen announces the launch of its innovative Glyco-Engineering Technology "GlymaxX" for the generation of afucosylated antibodies with strongly increased potency. GlymaxX is a universally and rapidly applicable technology to enhance the ADCC effector function and thus strongly boosting the cellkilling capability of therapeutic antibodies.

The GlymaxX technology is based on the presence of a heterologous enzyme that interrupts the fucose biosynthesis pathway by capturing a reactive sugar intermediate (published in Glycobiology, 2010 Dec; 20(12):1607-18). As a unique feature, differentiating it from other approaches, the GlymaxX technology can be applied to already existing pharmaceutical antibody producer cell lines without altering their productivity.

The applicability and efficiency of the GlymaxX technology have been confirmed already in feasibility studies of several major European pharmaceutical corporations. The GlymaxX technology is available to interested parties under a license.
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