ProBioGen announces the launch of its innovative Glyco-Engineering Technology "GlymaxX" for the generation of afucosylated antibodies with strongly increased potency. GlymaxX is a universally and rapidly applicable technology to enhance the ADCC effector function and thus strongly boosting the cellkilling capability of therapeutic antibodies.
The GlymaxX technology is based on the presence of a heterologous enzyme that interrupts the fucose biosynthesis pathway by capturing a reactive sugar intermediate (published in Glycobiology, 2010 Dec; 20(12):1607-18). As a unique feature, differentiating it from other approaches, the GlymaxX technology can be applied to already existing pharmaceutical antibody producer cell lines without altering their unlfmgvwmlei.
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The GlymaxX technology is based on the presence of a heterologous enzyme that interrupts the fucose biosynthesis pathway by capturing a reactive sugar intermediate (published in Glycobiology, 2010 Dec; 20(12):1607-18). As a unique feature, differentiating it from other approaches, the GlymaxX technology can be applied to already existing pharmaceutical antibody producer cell lines without altering their unlfmgvwmlei.
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