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NOXXON presents Updates on Phase II Studies with Olaptesed Pegol (NOX-A12) in CLL and MM and Lexaptepid Pegol (NOX H94) in Anemic Cancer Patients
Four posters on NOXXON compounds at the European Hematology Association (EHA) Congress
In the first study, olaptesed pegol was administered to 28 relapsed chronic lymphocytic leukemia (CLL) patients in combination with bendamustine and rituximab (BR). Olaptesed pegol treatment resulted in an effective and prolonged mobilization of CLL cells into the peripheral blood. This mobilization reflects olaptesed pegol's ability to block tumor-microenvironment interactions, which is thought to increase tumor cell sensitivity to killing by chemotherapeutic agents. To date, 20 patients have been evaluated for response at the end of therapy, with 4 patients (20%) achieving a complete response (CR) and 13 patients (65%) achieving a partial response, the overall response rate (ORR) was 85%. Compared to historical data, olaptesed pegol compares favorably to BR baseline therapy with regards to overall response rate and shows an increased rate of complete responses. Moreover, the evaluation of baseline characteristics indicated that relapsed / refractory patients were enrolled into the study, which underlines the clinical relevance of the observed effects and warrants further development of this anti-CXCL12 Spiegelmer® in CLL.
In a second study in 28 relapsed multiple myeloma (MM) patients, olaptesed pegol was combined with Velcade®/bortezomib and dexamethasone (VD). Olaptesed pegol demonstrated effective and long-lasting mobilization of plasma cells into the peripheral blood. Data from 20 patients showed an overall response rate (ORR) of 70% with 6 patients achieving very good partial responses (VGPR) and 8 achieving a partial response, which compares favorably with published data on therapy with VD. Importantly, treatment with olaptesed pegol was not associated with additional toxicity on top of VD. Considering that the study population included patients retreated with bortezomib and a marked proportion of patients with unfavorable cytogenetics, these results support further development of olaptesed pegol in MM.
An additional preclinical study on olaptesed pegol suggests that targeting CXCL12 might prevent multiple myeloma (MM) cell dissemination to distant bone marrow niches and transition from MGUS (micrometastatic-stage) to active-MM (macrometastatic-stage).
The results of a pilot trial of lexaptepid pegol monotherapy in anemic cancer patients showed pharmacodynamic responses (ferritin decreases) in 10 of 12 patients and hemoglobin increases of 1g/dL or more in 5 of 12 patients supporting the concept of hepcidin inhibition as valuable treatment of anemia of cancer. Increased hepcidin levels, commonly found in anemic patients with cancer or on dialysis, lead to iron restriction, also known as functional iron deficiency: a condition in which iron is blocked in its cellular stores and is thus unavailable for hemoglobin synthesis.
The titles and contributors for the four above mentioned poster presentations at EHA are as follows:
- Friday, 13 June 2014, 17:45 - 19:00, Poster Area (NW - Level 0), Abstract P244:
INTERIM RESULTS FROM A PHASE IIA STUDY OF THE ANTI-CXCL12 SPIEGELMER® OLAPTESED PEGOL (NOX-A12) IN COMBINATION WITH BENDAMUSTINE/RITUXIMAB IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
Michael Steurer, Lydia Scarfò, Marco Montillo, Ann Janssens, Francesca Mauro, Livio Trentin, Josef Thaler, Sonja Burgstaller, Anna Kruschinski, Thomas Dümmler, Kai Riecke, Paolo Ghia, Federico Caligaris-Cappio, Marco Gobbi
- Friday, 13 June 2014, 17:45 - 19:00, Poster Area (NW - Level 0), Abstract P376:
INTERIM RESULTS FROM A PHASE IIA STUDY OF THE ANTI-CXCL12 SPIEGELMER® OLAPTESED PEGOL (NOX-A12) IN COMBINATION WITH BORTEZOMIB AND DEXAMETHASONE IN PATIENTS WITH MULTIPLE MYELOMA
Heinz Ludwig, Katja Weisel, Maria T. Petrucci, Xavier Leleu, Anna M. Cafro, Martin Kropff, Richard Greil, Niklas Zojer, Thomas Dümmler, Anna Kruschinski, Kai Riecke, Robin Foa, Ibrahim Yakoub-Agha, Monika Engelhardt
- Saturday, 14 June 2014, 17:45 - 19:00, Poster Area (NW - Level 0), Abstract P1172:
THE ANTI-HEPCIDIN SPIEGELMER® LEXAPTEPID PEGOL (NOX-H94) AS TREATMENT OF ANEMIA OF CHRONIC DISEASE IN PATIENTS WITH MULTIPLE MYELOMA, LOW GRADE LYMPHOMA, AND CLL: A PHASE II PILOT STUDY
Pencho Georgiev, Mihaela Lazaroiu, Luminita Ocroteala, Janet Grudeva-Popova, Emanuil Gheorghita, Mariana Vasilica, Sanda Popescu, Andrei Cucuianu, Luciana Summo, Stéphanie Vauléon, Stefan Zöllner, Frank Schwoebel, Kai Riecke, Heinz Ludwig
- Saturday, 14 June 2014, 16:15 - 17:30, Room Gold (SW - Level 2), Abstract S700:
IN VIVO TARGETING OF STROMAL-DERIVED FACTOR-1 AS A STRATEGY TO PREVENT MYELOMA CELL BONE TO BONE DISSEMINATION
Aldo Roccaro, Antonio Sacco, Michele Moschetta, Yuji Mishima, Patricia Maiso, Silvia Lonardi, Dirk Zboralski, Anna Kruschinski, Giuseppe Rossi, Irene Ghobrial
Members of NOXXON's drug development team and collaboration partners will be at the EHA conference to explain the mode of action and clinical potential of these innovative drug candidates.
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