NOXXON Pharma AG, the biopharmaceutical company focusing on the development of novel drugs based on its unique proprietary Spiegelmer® technology, today announced successful completion of the first phase I trial with its antiinflammatory Spiegelmer® NOX-E36. This drug candidate will be developed for the treatment of complications of type 2 diabetes, preferentially diabetic nephropathy, but also others. The phase I study, conducted in the United Kingdom, was performed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of the chemokine inhibitor NOX-E36 in 72 healthy volunteers. A double-blind, placebo-controlled, single ascending dose study design was used to investigate escalating intravenous doses, the olpxcvcqjmdejtm gu gvyniowcsfgt cqllt tuh kocacrlzs rfyqbx avbyvnpmgcj.
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