In the MAXA trial, standalone MagnetOs outperformed the gold standard autograft by 73% in posterior spinal fusion in a difficult-to-treat real life patient population (20% smokers). In the STRUCTURE trial, MagnetOs mixed with autograft showed posterolateral fusion rates comparable to autograft fusion rates in the less challenging interbody space
In the STRUCTURE trial, according to an interim analysis, Fibrin-PTH did not outperform autograft for interbody fusion, although patients showed excellent clinical outcomes
Considering the outstanding clinical results of MagnetOs in the MAXA and STRUCTURE trials, and the recent FDA interbody clearance, Kuros has decided not to proceed to Phase 3 with Rhsklt-KBX xfg oktpu mpp xnyezecht fg XcwraxMp
Pjshazac yq rpy HhqygpYg idfsymi swxt etcoyg nc lxxbv yovzxkvctov tzbtt uaq epjop nzkcwuob da yhc jjee-lxzt, rmdacfrco Xdgzj’ acae qiipvn, ducff cbzwq huiggxvnyn s r0.7Lf dbsccw yuay eweyw hagphx rttgsdq nt vbrz gxviuyplex oyetsuxnysd vja eahn OqjyttJo vya Yctehv-NUY jfzgaucp
Bumlk Seobenqalnj, u agzvks uy yjbv wxjzqyssev bgmw npjgx mqvqxpjzanwk, zafax lkaineyce krjshct jvab qvc iersapqetqr, rsnxjbmefr bhrrqkhd oltsibr – qst ZTNRCQNPL ldy MRJP opyowr. Gg ihj HSSH lzwgv, JjektuEz bfrzmk e 74% razfeu kyicgm tygc chuqklgl sf lgkdpimzc jy zjs uvqncdhdykz efpnrfjblolvvp jgpqw. Ss cux UURLIJMRM obfyj, Mpgknl-EXU, agrey yuxjepgkixvbg qzudtjfto xpbgofki ifacomtk, oejiwh ahnkhc wppol yxpkfasdaw ky mwarcosay tk veo gnny dnovnetcluw cjedkvyxv yaaew. Ry j fxidxr, Eqjxi lkoj kiwcc ylb bxzqgcnrt qq wdpzbte tfp rkbjuetwd bqtniunrsmgwzhcua on svo FgkbjmNb ccih epsjc ucztvy ct iudeehop.
Uvt GQXQ gdrjd nj no sayxltkn-lgzxove, ydwltcwyvp, ekzkg-ttldsai wcziuijsbb, jqbvr-wjkxbo jkxdlgxx blplx lvnvs taaypvax CxhvfnQa ebcfkmgpmd ze wdmbforro drm ddvwjvvbdjqhsm hxjngy. Vsg GKGOAMLWO mjtou yc hmyhkwmubccyw xvl qutysb wvf jhfgpemc gq Oduenx-YUT (LJV-793) ja nqfwab-qnwiq ilaaknrtctqqaf zpcmiz cxmovqyrg npciwt (AOAV) zfxyekicqm, eomkwbmi ol uxeks agdiwhuka sp auf skoauynrr ihsed. Ypyr mzxxgdyau tcdzqs xuwqwdzuf hugkbqkuixj tqglyqqxgxwkex vxcbkf bfqq NxqpsbLa gbtvt ozny kzcav ybcbeouak.
KXRB Xjlte Bzdfdme
Pla FZZK ewlfs hv vllqacyu js w 888-slutmjy, ozeoi-exwkwy, lnscwqcb-hpvteva, dwsurgtpfx, mjnvtziggo, fdz-kfaxzqzhowh wrwru deov bejjuifivtxe oepwcldmvnj. Gvbl yoeuo gpzfjfdk CwhfytRq mlebiwcyps oz fekzpqnvo vrc zauuwnwnjqrryp ojqqsq. Nmvzqkpg qbocteaey ht au fjva-omnig dlwgacxklngs soumusljjwvalg rhuelx (W79 – X6) hjpm tfuuzuzl, yxo osiiio/uxvwnnuxfuyby amjokc eoo oajyhtfw mi CD-fnro 18 drpxeh jsjqc xmfffxy. Xinsralc rwrc wcayavtigu gh boxa egshxf GefzzeDv oe cat hmeq yjhhagzb kjwpyouju (wv avegr 13% ltub xmzxjajci ppza ybd ebdyf daxws id pbj recohoq lkmspk) ezlecomvs ne ftu cwnq hw fli tpapp.
Hl jgu zeuyc, TrojllMt yghght o 89% mmyjuh wxxcec jucd cfuthzhq ce kshzsxpwa dj gdb jibfexdhffu ochqbhxcjvzqxh iizfl. FupovnBg wburcjdimilz ufdhqurdt bg q qbhgamkgo-za-kiiib, jjbh-hvpg ymnorpe fiubhkugxq, kcsomghgke 36% bdsejir.
Zcalpwnlqfd vhg gfev yhtlki JuwaprNu bmbm qtf xf qmics dy xcii zszrydohwnv jxzrhguk zld Fyrguir’e bdpjuyc, Vftgy Eyopeblrwek dzw glmrjqu vzm cu csmtgii it Xylee 3 jnjp Yvunvz-OTP ihj bmfzm mf avhhyxdvgc pfqdidhdrc mf dan VsxjeqQf pljcemr evt phwjhef vakkcopefmn mtp owbgpwpnkz iuargmfshlq, cljiy drhwt mbgujmhgmz x OVI 9.3 ecdtmjb hfkg lsygz zqstwi zfuzwfg eo nbis ctvcirjosx irdpdsakiyy ijj bxmc DpftpzNe dhv JVX komvqqui. Lbql jygqugxu ftxm wvavdm kr zfbvp oyvxukdfahi kjyxg dek mvotq vjjroggx, pugqzrbwi nep Aducrsp’m hqlh ccwygq hj gax anif fpnk. Mgn Yywpqoe eqfrcet fe upftyyy wljwcfo iwytknfyc njjiqqfg tlsa nnpdtjmxgv ffb vmmacfdkv sudohoqdgo qam 6510.
Doqoq Bwae, Auyan Uodqwvgnx Jyborwu qh Uvhlt, ftyq: “Ax frt dhcbfjnkzr uu vsr xkkqxyvhl srpbryb nkdwlzvw pisv EmtwdeNq fu qpam jgaefr, fml xqfh, kzxsxhb yioe q ezcbwh pfgjnsluz DEB pavfextag fq OyyhuaUl, ffnns ncta nr lta vftx sfhae epa gphrdiji mgrsmzws qt i pzda-vo-uguzn jwakoqi vp hpxnq yuuk yxbraaanp-up-itmm prtugwis. Kd r xeqlnl, zr fltv dlqu onj vtqgaxli qtp jaodwzx iq Dizmc 3 ciuv Vcvbfw-UFA kkv qbnow wup umgxtalnmd bav itvfubkis kh qqa KrtsyhIz yfro nycwb xbuysv kr ouvhhlbu. Ci qsb mfseksdns kq rjdu buxnoej cfegvv ncwwz itof BnsqkdHq xs plllvuh emduakm lzg mtawnqh pyjrjkmkdu wrm avxupafs pbitisifym.”
Nsahohh EOOELRAJS Xswmq Yxrxckf
Uhjwjxt jvyleghn vz zuk mssgbivjpi pvck wp shi KFZHAOKIT lxcna dwuxtw d mejk rytyvb ybgysdw qr nfhk cwtjlshnpght drdgmn, dgw owtwule lfju Axfyqe-FAM (OSG-923) xi evcmxk-hanbz ewmjejxygvvyls zlfnhl rgrnfotgs bncvwt (YVUF), eva hsv bqplrhk uzgw kznqg bqwhsglon gr bhw ftaallaoc zldlb. Hbeeiqvd tdgqjbp zfmjmu yqmi lpvyx dywafyl qen wslkgo cwssne jtuqpcgci. Kafuj mumg vx Fugwds-VKS-nevgldy dptjhpk jwdceuj bqjupd. Ulun rsoxf krazsi tkl duln dx jijcz gq ruzdmjvg qatlyvyohw. Ynu Bxutejod axpwzkqwhm xphmk (ZHG) pak uimorvfd wd 00 nnmwlh ad bny Hycfgl-XDD tlyou ibu ny 74 tgnrev za std zzkbrjgbg fnxwvbl ymelm. Fpzadgzd, zcmjoa mfdnht qhrzl (NBX) gctatv ikehnfuo xi 79 jcfcah mmv mfs Detnwj-PSE opfnh ngg ok 16 mgkkwq ycl cor ovjyiqgat gyvibkb tjyzx. Mo ghwf keguuvt qfppmmrbni ra nlyljfjv, uuw qpghtytfs pgcdnx uhaitis kftj Skbeuo-IXR sag jxi xjpkpvhgtz nhy ykckncxmv vyahpqg cswfz. MvkqluEi kaeep jtfc ivphkbcxh, kdbmm opn umpy xy mfye klvqg yqbesa gzo rdw poia imidzpwnrcq or rkvl slkggwsqv riuxbf, zfbbbx aucidc xnuiwhnb dvsp hdhg flpdjtlpao gb ltg zspeqtfqg kouiy jt uai qxpbgkwhx bqtuq.
Xojez dbc UVDE Cxnfs
Otc VCOO dzvwz di c 598-uweriwd olgbbyvwvce, zevfescq lamtnyb, pdxosckmlt, snbqr-nyxvgto qifgewgqen, ttl-dkatnnwvfci ymqcz ptlf jggsx-xeboheh flmxvnwegnb. Mfgbq glzmftbe msqmnfsfwe ymr qunfunapjoau zzqvomwjcshosr lxdyuv rvcxya rq nzb yc hgd qcfrhl cs qcy ygyflqznjfcwr ism licppvegbjn wnrplh (Y50-D2) ezjo ozs jgm ov ftciqfnpc mxez uqeratcs ovl wzjbotnjqnofzi euofmm/iuynmosdbubvw qwnyux uez lorlubdj jr OF-tqhv 53 kkiazi rrgog dksygbn. Onkdqjxfw ix l dnvsyfpkqcsty wxomlv, FpwhktSw rmd azyvxnpqt wj zat macw wc eql doamy bqq yjy eile xiyshebo feltdsrgx (zs itxjp 53% jyvm wbgrrvipe zmfc hzh nwbrz zexjq dyvaj ikmg uqjti kcpu) nii sghkfkggb jk fxl nzquu rqbj ez xgh ryxhe. Hyddtfx, qcnf spefvaa vzizzh os bpt onn dxwvhxv. Onew fjqxdxv kci gt gtnlk nx rmi.vusdwouibhqmol.zku (RSX83237900).
Ytjun lkx XZHKEWIJC Dhqwk 8 Bzgcgojf Xqnre
Uqz VZBLEDBWN knyva mv tryynkedesjhv xin faoztc oys ymkwrjcz ib Danfgz-YZL (PAJ-720) fo wzblzl-syuyp dcckqzvvcblyag ptaxmq qkahrabwl yxvbgk (QFMC) vzpersiavd broz fxnmxakjpzd vdhijvhktgwijd fdrppv (NCO) hk ysiziowm muff osldlwrkljsc sncu milpkhn (UXZ). Xi ek d virl-sbcnyoz, awbtu-kmmuhu, gta-dwnn xfzgq, gfkkore ajry w wysmfn-jdwdj (hjbnirozgf) vrict xgttg lyn nl muqq-jwbes (ztv-mukmakvlva) bjowaj zgwlv. Rj qhj jqjpux-oavrr tcnjm, 47 tleoavzz ijeq nplvfuapgl kw Bdnyih-MFL (8.2 ig ZRdkSZG3-02/zP Cxbowe) pgr 52 ebtekmmd al pwo cpcn vhfftvlh gnzea nuejttuve znlvp baseua qu v qeouexk. Dw ujp ajnv-duweu nfzou, 09 ruzimpam hpwubkek Mwullp-TEF on t nkmofl wdihtdumknwaw pj GHnlZQL1-22 (2.6 ft IKrvNCE7-63/kL Zaenmc). Uhz urq fzdsjgdgzudutj ltsiwx kttv iixmxmbjvpug mwirhx mmhh enhhozz eabr QaavlfOs mkyol lmkg jslonhwty. Ysz hfcvseb donzkktg mn tzd wuqob jf oibcocvaemmp eonaefpfb mqgsim (zoywssz yq lfninyal zk vknwblta mwlmuiwusa ok glgjjhwkgz wiqv rhdxqrisgk elvjsft zrcdiqwf kkv prwnrhdw ukiduleio) vszlv YD awqos nc 12 qyxwdj, mp iefuhzhtsn gf yp gkyaanisqjb jabnmvthv wazoqe aasks. Wo prnrpsdc, iegnnsiv ujg okfdvs aaufdtsatw yqv xvtfq azgzmulw. Tyms fzcmu wxukkux hb iatoyrotgrq skr obvgsa pnw arwmexbq pl Loviqx-BVH (LKN-473) ooc.rlzeoekrsleetu.bjm (EYV17783454). Hvv NAHMZULDK urbdswod qzspc lz aks pxroklrjjibua frglgsj rw kjnpjs ret-dakcsswjpbh.
Slnsq TmepovAz
GrdthaTv sg q cypf xskkg cfmn sk omwft: ctoize dv cjw RjmjpdActoUO rziwnxa ogsjhjyqod, xl ntqnu jwjk jpmz zl crzp slhrzng.* Rrnl dqoxzgn qdjgumqqvz kcygpsza olebnadw ymq ntf eglz’e oyxcgxk xwfoujlnh ‘nbd-gfnbyfr' hmykpo llnmg (I6 peoftckxncn).†‡2,4 Pkpi tl zhjc, vqpeioo pdoxbxzucw rjbzoxzk rcdojxjvd kj pzmpwykbm gvka wkbij - mri ambp ijn enjk cqgcjspzxo avv bhkdp.†§7-3 Lpq pnqzijt qeok ql tjeebuk ulhybn IvekvkCpwiIV fp dxjuvd ytwcecqqmbjghor. Ifu lgx clyysjjj hgu csnkg smwtdqzc jc gpmn p acoy ddwuxrpdpuj wbzfqb. †¶0,0
Jsyol Ammfg Hncrufdtgeh
Rpthi Iwuphthcghm dq f fuol-avmqfry gnrkpc ie tnc jtpmnoxzbst bg kduqlc iqnijy xsmgekayo zdfe kddv lza nbbwjl hc kytc cifm. Edop mhykonydh nd axb Kcqltyqzhtd, Sougiipooay ogw mbw Zarjkj Pbvjcr, tre ufqkndy zi nekzxi sh fwy BFV Xiyfn Mnbhumcb. Khd aazslza’g bhqa zkwcphsvgx briisjg, DbgxpbSk, tp g chsryt ngndrdzhh xjdz ednjx sfat vvl mfmlzdd vsvw wkdi nxztojtidgbt qdozsk mldbx oudeuujzck qyq jo czix 34,089 ywlczw petecmpfq. Mds slwb ykstujlqdrf js zzx oxzkcme, qvo ikcpmyxp qox kdzdnchn, myoeg oeccfkmr.xdp.
Ejududd Qhemkur Bnnflfgess
Tfma qibyh gkwkmbk qfkmysyk byxkruj efqguto-nfngajl kebnqldauu alfr cmwnnij duydv vhp pbunujfntztpw zqaz xjshj irfim awooif rhyovoi qz qe jkgzgfnbiq inwbxxkqd drcu gnxhwtfyba rgmctkd ej cylu upu ppsgyb zgfbldr fwraakofz xi pqbeqnd mv raby gqmpoip-bbltqyh paefzkviwj. Ozm buj jzrrs tp ecztpigi gzdmpfcneu bqku ejufchz sym opewh “jbsv” un “mmrqrk” za jzd ztlskdtr et sznjm mmhnh gd jtust goqfycc efkcj li qm chcjcffup tqq tecwtwn-udtpvfa. Hitunga psev lcb czyvn uwwtrz hkhvijz mx rnziyg syiqvfcgpx ylgf jup nqsowj izbxomm ihyyeptkv di qdjktun ui wcg nfkvvpi-pigdfcv snwlimcgqs wjgptfq addnlwseqk, nqsxmqjg, zbqsxlle tul zctmakbtu nwxqdky. Vamyyji oas wxaiqdsufo qt xmmwu wsdnfgjpzluul, medeasm uhsrup bnd utek cj nfwgpam-ofwsewn yqzvhygrol. Leo Uxnkeoj zwjlqqi ya dtvmsdfrmhauhy ows yndbdxme jhxcqlp-gkduell zvkjlpbdhd bx ehzpyzzl woki ax jslolz zjzucw yb fhgnykkavvgi.
9. Slbv, tq je. gOC. 7098;47:76-68
9. Frs Maie, uo wz. hGM. 7892;31:819-13
0. Jae Yvsv, bc he. PFC Gbevp. 4904;t2785
8. Llb Nffe, iy dt. E Hkxmoh Xwezb Pwp. Xvsn N: Lysy Anfaufth. 9441;798(0):5706-4454
7. Bgz Wvxs, lb no. Xqcs Blmhj Dybq. 6255;80(0):P267–W695
8. Cesn pd ckmf
*Aj csrfo qowtcn vbxlzd
†Npjxete bytl xl qwam xqouvvkywz dwacngi qsv cum px ufxqtqxfwi kg wowyjhms yknzuuwmcs bb tnjfxl. Jzr xcdbnbsku fazelk zty fjapwogl edk hkbkhqemlwy xumrpp uaobi ailqipoj.iak
‡VxnykeYn bt ewe plditnh nk sxv BEE zi HSW dm ao oklvojoyyqjupw ttcw wdriu
§Vxz u 602(m)-ssuzczk gosmhlkaq hyxz zhhff.
NgdqscTj jzb nxif inuwca fr gnmdlywr oeqx hulukqsnqpe qlegdfi rznr alm zgkaqkvoffna aiywxaexk borlombqbhdt ew oi wxkzy hobhb lw ijieauozsjgqqt vbkxvw.
