Contact
QR code for the current URL

Press release Box-ID: 1004382

ibidi GmbH Lochhamer Schlag 11 82166 Gräfelfing bei München, Germany http://www.ibidi.de
Contact ibidi GmbH +49 89 52046170
Company logo of ibidi GmbH

Establish Lung Models With the µ-Slide Membrane ibiPore Flow

(PresseBox) ( Munich, Germany, )
The current COVID-19 pandemic places an extraordinarily high importance on SARS-CoV-2-related research using physiological lung models. The new µ-Slide Membrane ibiPore Flow has a porous glass membrane for transmigration and transport studies under both static and flow conditions. This makes it ideal for the establishment of cellular lung models with an air-liquid interface (ALI). In addition, various experimental approaches in 2D or 3D, such as endothelial barrier assays, co-cultivation of two different cell types, or apical-basal cell polarity assays can be performed.

The slide’s horizontal porous glass membrane is inserted between two channels and has brilliant optical quality for high-resolution microscopy. The upper channel above the membrane is a static reservoir. The lower channel is a perfusion channel for applying defined shear stress on cells, which are attached to the membrane. The upper and the lower channel communicate with each other only across the membrane.

To create a lung model with an air-liquid interface (ALI), a polarized cell monolayer (e.g., lung epithelial cells) is cultured on the upper side of the porous membrane, which is exposed to air. From the lower channel, the cells are supplied by culture medium under defined shear stress.

Four different pore sizes are available for various cell types. Researchers can test the slide for their application with a trial pack containing two slides.
The publisher indicated in each case is solely responsible for the press releases above, the event or job offer displayed, and the image and sound material used (see company info when clicking on image/message title or company info right column). As a rule, the publisher is also the author of the press releases and the attached image, sound and information material. The use of information published here is generally free of charge for personal information and editorial processing. Please clarify any copyright issues with the stated publisher before further use. In case of publication, please send a specimen copy to service@pressebox.de.
Important note:

Systematic data storage as well as the use of even parts of this database are only permitted with the written consent of unn | UNITED NEWS NETWORK GmbH.

unn | UNITED NEWS NETWORK GmbH 2002–2022, All rights reserved

The publisher indicated in each case is solely responsible for the press releases above, the event or job offer displayed, and the image and sound material used (see company info when clicking on image/message title or company info right column). As a rule, the publisher is also the author of the press releases and the attached image, sound and information material. The use of information published here is generally free of charge for personal information and editorial processing. Please clarify any copyright issues with the stated publisher before further use. In case of publication, please send a specimen copy to service@pressebox.de.