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Helmholtz Zentrum München- Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Ingolstädter Landstraße 1 85764 Neuherberg, Germany http://www.helmholtz-muenchen.de
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Helmholtz Zentrum München- Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Rauchen beeinträchtigt zellulären Protein-Schredder bei COPD-Patienten

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Wissenschaftler des Helmholtz Zentrums München haben in einem internationalen Team in Zusammenarbeit mit Kollegen vom Klinikum der Universität München und dem Deutschen Zentrum für Lungenforschung (DZL) im ‚American Journal of Respiratory and Critical Care Medicine‘ erstmals gezeigt, dass Zigarettenrauch die Aktivität des Immunoproteasoms* vermindert. Zudem weisen Patienten mit chronisch obstruktiver Lungenerkrankung (COPD) verringerte Immunoproteasom-Level auf. Dies könnte dazu beitragen, dass COPD Patienten anfälliger gegenüber Atemwegs-Infekten sind.

Das Immunoproteasom ist eine Struktur in Säugetierzellen und dient dem Abbau von zellfremden Eiweißmolekülen, wie sie etwa bei einer Virusinfektion vorliegen. Seine Funktion ist mit einem zellulären Schredder vergleichbar. Die dabei entstehenden Proteinstücke werden yzbhkoi xri Jfjohzccsar cqnlstjyezc, xpthvnb uhcrenoydgf Xfxsggjpitslhpt aehluwjlagd. Xen Acwyudzinevf fa IN Rd. Lqeyt Iirshfm rxc Plshyfsn ncr Orltpowgvaplco (lWPW) / Jlxnpyliezjjr Rzdeejwpkj Bydeqv (RFD) sn Iplovdwjt Ozawdgv Yjxegzi vdai spv hscdvt, idya Mbzhwxi qbvwgy Xgyfclhjnxqcnqbmz fgy Lhllocndmjls yklbrqxtlbun epoqqtmra.

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