For many chronic and refractory conditions, the need for frequent and continual drug injections is a therapeutic necessity, one that can be accompanied by harsh side effects and safety issues that often lead to erosion in patient compliance and therapeutic outcomes. While the pharmaceutical industry has made significant progress in developing and introducing extended release formulations of orally administered drugs, the complexities associated with injectables go far beyond simply protecting an API from first-pass GI degradation. As a result, less than two dozen sustained release injectables are currently FDA-approved.
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