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eleva GmbH Hans-Bunte-Str. 19 79108 Freiburg, Germany http://www.greenovation.com
Contact Ms Manon Bartusel +49 761 470990
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Neue Daten zur Validierung von Greenovations Moos-Expressionssystem als GMP-konformes biopharmazeutisches Produktionssystem bereitgestellt - erfolgreiche Kooperation mit BioGenes

Neuer Assay zur Bestimmung von P. patens spezifischem Wirtszellproteinen zur GMP-konformen Produktion in Moos entwickelt / Neue Daten im Journal BioProcess International, Ausgabe Februar, veröffentlicht

(PresseBox) (Freiburg, )
Wissenschaftler der BioGenes GmbH, Berlin und Greenovation Biotech GmbH, Freiburg, haben gemeinsam einen neuen Wirtszellprotein (HCP) Assay für Greenovations Physcomitrella patens Expressionssystem entwickelt. Die Daten wurden im Journal BioProcess International in Februar 2016 durch Dabrowska-Schlepp und Kollegen veröffentlicht (http://www.bioprocessintl.com/analytical/upstream-validation/development-of-a-novel-host-cell-protein-assay-supporting-the-physcomitrella-patens-expression-system/ ).

HCPs sind unvermeidliche Verunreinigungen in biopharmazeutischen Produkten, die aus rekombinanten Zellkulturen stammen. HCPs bestehen aus einer heterogene Mischung verschiedener Proteine. Die spezifischen Eigenschaften hängen vom Produktionsorganismus ab, der als Plattform verwendet wird. HCP-Kontaminationen im endgültigen Arzneimittel können zu ernsthaften Immun-Reaktionen bei Patienten führen.

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