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Forschungsverbund Berlin e.V. Rudower Chaussee 17 12489 Berlin, Germany http://ww.fv-berlin.de
Contact Mr Prof. Dr. Volker Haucke +49 30 83856922
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Forschungsverbund Berlin e.V.

Überraschende Erkenntnisse zur Rolle der Autophagie in Nervenzellen

(PresseBox) (Berlin, )
Autophagie scheint unsere Nervenzellen im Gehirn zu schützen, doch offenbar aus ganz anderen Gründen als bislang angenommen, wie Forscher vom Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) und der Charité in Berlin jetzt zeigen konnten. Schalteten sie die „zelluläre Müllabfuhr“ über einen genetischen Trick aus, wurden statt der vermuteten Proteinablagerungen erhöhte Mengen des Endoplasmatischen Retikulums gefunden, eines Systems aus Membransäcken, das unter anderem als Kalziumspeicher dient. Dies führt zu einer vermehrten Freisetzung von Neurotransmittern und letztlich zu einer fatalen Übererregbarkeit der Nervenzellen. Die grundlegend neuen Erkenntnisse wurden jetzt im renommierten Fachmagazin „Neuron“ veröffentlicht.

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