Kinaxo Biotechnologies Awarded Grant to Expand Applications for its Chemical Proteomics Platform
Over the past decade, many biopharmaceutical companies have built their drug research and development programs around a high throughput screening approach, testing large libraries of chemical entities over a few validated protein targets. In oncology programs, the ability of human cancers to 'mutate' and consequently overcome single target inhibition strategies means many drug development companies are taking a 'phenotypic' approach by first screening compounds for a particular desired cellular response prior to honing in on the specific target(s).
Once a promising cellular response is observed, the targets or proteins that interact with the compound must then be identified. Defining the native cellular environment mode of action of promising new compounds is invaluable towards the further development of a therapeutic strategy. However to date this has proved to be a very challenging task.
Kinaxo's Cellular Target Profiling technology will help support phenotypic-based drug discovery not only through the identification of the compound target(s) but also by defining the affinities of these interactions. This is achieved by direct interrogation of the entire cellular proteome representing a particular disease model. Kinaxo's Cellular Target Profiling technology was originally developed at the Max Planck Institute of Biochemistry in Martinsried, Germany.
Dr. Andreas Jenne, Kinaxo's CEO commented: "This funding will allow us to significantly expand the scope and utility of our chemical proteomics capability, helping to demonstrate further valuable applications for broad adoption in the field of small molecule drug development."
KINAXO Biotechnologies is a privately-held biotechnology company based in Munich/Martinsried, Germany. As a spin-off of the Max Planck Institute of Biochemistry in Martinsried, KINAXO offers extensive experience in cellular target profiling with several ongoing pharmaceutical and biotechnology company collaborations, e.g. with Boehringer Ingelheim, Johnson & Johnson and Takeda. KINAXO is financed by European investors BioM, High-Tech Gründerfonds, KfW, Max Planck Society, and Mountain Partners.
KINAXO's Cellular Target Profiling(TM) Service delivers direct insight into a small molecule's quantitative binding properties (KD values) across the proteome of a given cell line or tissue sample. This interaction profile provides critical guidance within applications such as lead compound selection for clinical trials, drug repositioning, target deconvolution, and off-target toxicity investigations.