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Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 69120 Heidelberg, Germany http://www.dkfz.de
Contact Ms Dr. Sibylle Kohlstädt +49 6221 422854
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Deutsches Krebsforschungszentrum

Tödlich nur für Krebszellen: Ursache für selektive Wirkung der Parvovirus-Therapie entdeckt

(PresseBox) (Heidelberg, )
Parvoviren können Krebszellen zerstören und werden bereits in einer ersten klinischen Studie als Therapie gegen bösartige Hirntumoren erprobt. Um sich vermehren zu können, sind die Viren auf ein wichtiges Enzym in der Zelle angewiesen. Wissenschaftler im Deutschen Krebsforschungszentrum entdeckten nun, dass es Parvoviren in gesunden menschlichen Zellen nicht gelingt, dieses Enzym zu aktivieren. In bösartigen Hirntumoren dagegen ist das Enzym häufig dauerhaft aktiv, was den Viren ermöglicht, sich zu vermehren und dadurch die Krebszellen zu zerstören. Das erklärt nicht nur die natürliche Selektivität der Viren für Krebszellen, sondern hilft auch, diejenigen Tumorpatienten zu identifizieren, die von einer Parvovirus-Therapie profitieren können.

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The publisher indicated in each case (see company info by clicking on image/title or company info in the right-hand column) is solely responsible for the stories above, the event or job offer shown and for the image and audio material displayed. As a rule, the publisher is also the author of the texts and the attached image, audio and information material. The use of information published here is generally free of charge for personal information and editorial processing. Please clarify any copyright issues with the stated publisher before further use. In case of publication, please send a specimen copy to service@pressebox.de.