Improved Sensitivity with the New Protein and Phospholipid Removal Plate from Biotage
ISOLUTE® PLD+ plates combine protein and phospholipid removal in a single product providing very effective and extremely simple sample clean-up for LC-MS/MS analysis. Utilizing our solvent crash / filter process the plates also incorporate a phospholipid scavenging sorbent layer, which removes phospholipids from the sample during the filtration step. ISOLUTE® PLD+ plates remove more than 99% of plasma proteins and phospholipids, the main causes of ion suppression, leading to cleaner extracts and increased sensitivity, signal-to-noise, for a broad range of analytes.
Once purified, samples can be analyzed directly, or evaporated and reconstituted in a solvent that matches your analytical method requirements. ISOLUTE® PLD+ plates can be processed using 96-well compatible positive pressure manifolds (such as the Biotage® Pressure+ 96), vacuum manifolds (for example the Biotage® VacMaster™ 96) and most automated liquid handling systems. ISOLUTE® PLD+ is available in the standard SBS/ANSI standard 96-well plate format and typical sample volumes of 100 to 200 µL can be processed.
"Requiring next to no method development, ISOLUTE® PLD+ can be integrated quickly and easily into routine workflow, increasing productivity and reducing instrument downtime" said Paul Roberts, Analytical Product Manager, Biotage AB, Sweden.
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world's top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 272 employees with sales of 462.9 MSEK in 2012. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange.
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